Detailed information NTG0000348

Bioinformatically predicted

Overview

• Name: endA
• Type: Machinery gene
• Locus tag: STU_RS14880
• Genome accession: NC_006448
• Coordinates: 1023979..1024860 (-)
• Length: 293 a.a.
• NCBI ID: WP_011226089.1
• Uniprot ID: Q5M441
• Organism: Streptococcus thermophilus LMG 18311
• Function: cleavage of dsDNA into ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 1018979..1029860

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STU_RS14855 (stu1160)	vicR	1019684..1020391 (-)	708	WP_011226084.1	response regulator YycF	Regulator
STU_RS14860 (stu1161)	-	1020918..1021685 (+)	768	WP_011226085.1	amino acid ABC transporter ATP-binding protein	-
STU_RS14865 (stu1162)	-	1021697..1022530 (+)	834	WP_011226086.1	transporter substrate-binding domain-containing protein	-
STU_RS14870 (stu1163)	-	1022548..1023246 (+)	699	WP_011226087.1	amino acid ABC transporter permease	-
STU_RS14875 (stu1164)	-	1023258..1023908 (+)	651	WP_011226088.1	amino acid ABC transporter permease	-
STU_RS14880 (stu1165)	endA	1023979..1024860 (-)	882	WP_011226089.1	DNA/RNA non-specific endonuclease	Machinery gene
STU_RS14885 (stu1166)	-	1024922..1025110 (-)	189	WP_011226090.1	DNA-directed RNA polymerase subunit beta	-
STU_RS14890 (stu1167)	murA	1025112..1026383 (-)	1272	WP_041828250.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
STU_RS14895 (stu1168)	-	1026453..1026689 (-)	237	WP_002946959.1	DUF1146 family protein	-
STU_RS14900 (stu1169)	galE	1026877..1027890 (-)	1014	WP_002946961.1	UDP-glucose 4-epimerase GalE	-
STU_RS20640 (stu1170)	-	1027905..1028108 (-)	204	WP_011226092.1	hypothetical protein	-
STU_RS20645 (stu1171)	-	1028124..1028360 (-)	237	WP_011226093.1	DUF4832 domain-containing protein	-

Sequence

Protein

• Length: 293 a.a.
• Molecular weight: 31757.50 Da
• Isoelectric Point: 10.1789

>NTDB_id=348 STU_RS14880 WP_011226089.1 1023979..1024860(-) (endA) [Streptococcus thermophilus LMG 18311]
MAKRKTSLTNKQKRQLVTLIIAALIAVLGYLGTSNKLSPDNPIRQVASLVAGKSNKSIKSNGSTNSQSTPQEQLAETVMT
SSVKSQLGNSLEWNGAGAYIINRNKTNLNAKVSSQPYANNQVKTVQGQTVPTVANALLSKATRQYKNRQETGNGSTSWTP
AGWHQVQNLSGEYSHAVDRGHLLGYALIGGLKGFDASTSNPENIAVQTAWANQAYSDSSTGQNYYESLVRKALDKNKRVR
YRVTLIYEGENLIPSGTHLEAKSADGSLEFNVFVPNVQEGITLDYYSGKVTVN

Nucleotide

• Length: 882 bp

>NTDB_id=348 STU_RS14880 WP_011226089.1 1023979..1024860(-) (endA) [Streptococcus thermophilus LMG 18311]
ATGGCAAAAAGAAAGACATCTTTGACAAATAAACAGAAACGTCAGTTAGTCACATTAATAATAGCAGCTTTGATAGCTGT
TTTAGGTTACCTAGGAACCAGTAACAAGCTCTCGCCTGATAATCCTATCAGACAAGTAGCAAGCCTAGTTGCAGGGAAAT
CTAACAAATCCATTAAATCTAATGGTTCAACAAATAGTCAGTCTACACCACAAGAGCAGCTTGCTGAGACAGTAATGACT
AGTTCAGTCAAAAGCCAACTGGGTAATTCCTTGGAATGGAATGGAGCTGGGGCCTACATTATTAATAGAAATAAGACGAA
TCTAAATGCTAAGGTATCAAGCCAACCCTATGCTAATAACCAAGTCAAAACGGTTCAAGGACAAACTGTTCCTACAGTTG
CTAATGCCTTATTAAGTAAAGCAACTAGACAGTACAAAAATCGTCAAGAAACAGGGAATGGTTCAACCTCTTGGACACCA
GCTGGATGGCACCAGGTTCAAAATTTATCAGGAGAGTATAGCCATGCCGTAGATAGAGGCCATTTGCTAGGTTATGCACT
GATAGGTGGTTTGAAAGGATTTGATGCCTCGACTTCAAATCCAGAGAATATTGCTGTTCAAACTGCTTGGGCAAATCAAG
CATATAGCGATAGTTCTACAGGCCAAAACTATTATGAAAGCCTAGTACGAAAAGCCCTGGATAAAAACAAACGTGTTCGT
TATCGTGTGACCCTGATTTATGAAGGAGAGAATCTCATTCCATCAGGAACACATCTTGAAGCTAAGTCAGCAGACGGCTC
ACTTGAGTTTAATGTCTTTGTTCCAAATGTACAAGAGGGAATTACACTAGATTACTATTCAGGAAAAGTAACGGTGAATT
GA

Domains

Predicted by InterproScan.

• DNA/RNA non-specific endonuclease (Endonuclease_NS) (101-266)

3D structure

• AlphaFold DB: Q5M441

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
endA	Streptococcus pneumoniae Rx1	72.803	81.57	0.594
endA	Streptococcus pneumoniae D39	72.803	81.57	0.594
endA	Streptococcus pneumoniae R6	72.803	81.57	0.594
endA	Streptococcus pneumoniae TIGR4	72.803	81.57	0.594