Detailed information    

insolico Bioinformatically predicted

Overview

Name   prx   Type   Regulator
Locus tag   M6_RS06005 Genome accession   NC_006086
Coordinates   1200261..1200443 (-) Length   60 a.a.
NCBI ID   WP_011184726.1    Uniprot ID   -
Organism   Streptococcus pyogenes MGAS10394     
Function   Inhibit ComR activation (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1200261..1233773 1200261..1200443 within 0


Gene organization within MGE regions


Location: 1200261..1233773
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M6_RS06005 (M6_Spy1194) prx 1200261..1200443 (-) 183 WP_011184726.1 hypothetical protein Regulator
  M6_RS06010 (M6_Spy1195) mf2 1200683..1201441 (+) 759 WP_011184727.1 DNase Mf2 -
  M6_RS06015 (M6_Spy1196) speC 1201552..1202259 (+) 708 WP_002985327.1 streptococcal pyrogenic exotoxin SpeC -
  M6_RS10265 - 1202328..1202750 (-) 423 WP_410204536.1 SH3 domain-containing protein -
  M6_RS06020 (M6_Spy1197) - 1202763..1204394 (-) 1632 Protein_1167 IS1182 family transposase -
  M6_RS06025 (M6_Spy1198) - 1204433..1204642 (-) 210 WP_011184729.1 hypothetical protein -
  M6_RS06035 (M6_Spy1199) - 1204760..1205215 (-) 456 WP_011184730.1 phage holin family protein -
  M6_RS06040 (M6_Spy1200) - 1205225..1205836 (-) 612 WP_011184731.1 DUF1366 domain-containing protein -
  M6_RS06045 (M6_Spy1201) - 1205839..1206267 (-) 429 WP_011184732.1 DUF1617 family protein -
  M6_RS06050 (M6_Spy1202) - 1206276..1208057 (-) 1782 WP_011184733.1 gp58-like family protein -
  M6_RS06055 (M6_Spy1203) - 1208072..1209181 (-) 1110 WP_011184734.1 hyaluronoglucosaminidase -
  M6_RS06060 (M6_Spy1204) - 1209181..1211154 (-) 1974 WP_011054676.1 phage tail spike protein -
  M6_RS06065 (M6_Spy1205) - 1211136..1211831 (-) 696 WP_002992579.1 hypothetical protein -
  M6_RS06070 (M6_Spy1206) - 1211828..1214191 (-) 2364 WP_011184735.1 phage tail protein -
  M6_RS06075 (M6_Spy1207) - 1214191..1214562 (-) 372 WP_011054678.1 DUF5361 domain-containing protein -
  M6_RS06080 (M6_Spy1208) - 1214577..1214840 (-) 264 WP_010922455.1 hypothetical protein -
  M6_RS06085 (M6_Spy1209) - 1214851..1215441 (-) 591 WP_011054679.1 hypothetical protein -
  M6_RS06090 (M6_Spy1210) - 1215457..1215792 (-) 336 WP_000573598.1 hypothetical protein -
  M6_RS06095 (M6_Spy1211) - 1215793..1216029 (-) 237 WP_000032787.1 hypothetical protein -
  M6_RS06100 (M6_Spy1212) - 1216022..1216360 (-) 339 WP_011054681.1 hypothetical protein -
  M6_RS06105 (M6_Spy1213) - 1216320..1216742 (-) 423 WP_011054682.1 phage Gp19/Gp15/Gp42 family protein -
  M6_RS06110 (M6_Spy1214) - 1216752..1216952 (-) 201 WP_010922460.1 hypothetical protein -
  M6_RS06115 (M6_Spy1215) - 1216952..1217863 (-) 912 WP_011054683.1 phage major capsid protein -
  M6_RS06120 (M6_Spy1216) - 1217888..1218349 (-) 462 WP_010922462.1 capsid assembly scaffolding protein Gp46 family protein -
  M6_RS06125 (M6_Spy1217) - 1218430..1219845 (-) 1416 WP_011054685.1 terminase -
  M6_RS06130 (M6_Spy1218) - 1219927..1220142 (-) 216 WP_011106704.1 hypothetical protein -
  M6_RS06135 (M6_Spy1219) - 1220144..1220410 (-) 267 WP_002986828.1 hypothetical protein -
  M6_RS10130 (M6_Spy1220) - 1220403..1220555 (-) 153 WP_011054687.1 hypothetical protein -
  M6_RS06140 (M6_Spy1221) - 1220632..1220856 (-) 225 WP_002994100.1 hypothetical protein -
  M6_RS06145 (M6_Spy1222) - 1220862..1222355 (-) 1494 WP_010922467.1 hypothetical protein -
  M6_RS06150 (M6_Spy1223) - 1222348..1223616 (-) 1269 WP_011184740.1 phage portal protein -
  M6_RS06155 (M6_Spy1224) - 1223613..1223969 (-) 357 WP_002994106.1 hypothetical protein -
  M6_RS06160 (M6_Spy1225) - 1224117..1224461 (-) 345 WP_011054690.1 HNH endonuclease signature motif containing protein -
  M6_RS06165 (M6_Spy1226) - 1224569..1224988 (-) 420 WP_011054691.1 DUF1492 domain-containing protein -
  M6_RS06170 (M6_Spy1227) - 1225064..1225315 (-) 252 WP_011054692.1 hypothetical protein -
  M6_RS10135 (M6_Spy1228) - 1225312..1225467 (-) 156 WP_011054693.1 hypothetical protein -
  M6_RS06175 (M6_Spy1229) - 1225464..1225781 (-) 318 WP_011054694.1 DUF1372 family protein -
  M6_RS06180 (M6_Spy1230) - 1225817..1226329 (-) 513 WP_011054695.1 hypothetical protein -
  M6_RS06185 (M6_Spy1231) - 1226326..1226658 (-) 333 WP_011184741.1 hypothetical protein -
  M6_RS10015 - 1226669..1226884 (-) 216 Protein_1202 PcfJ domain-containing protein -
  M6_RS06190 (M6_Spy1232) - 1227045..1227440 (-) 396 WP_011054698.1 Cas9 inhibitor AcrIIA9 family protein -
  M6_RS06195 (M6_Spy1234) - 1227805..1228602 (-) 798 WP_011054699.1 PD-(D/E)XK nuclease-like domain-containing protein -
  M6_RS06200 (M6_Spy1235) - 1228595..1228795 (-) 201 WP_000594115.1 hypothetical protein -
  M6_RS06205 (M6_Spy1236) - 1228792..1229718 (-) 927 WP_011054700.1 recombinase RecT -
  M6_RS06210 (M6_Spy1237) - 1229721..1230050 (-) 330 WP_010922207.1 hypothetical protein -
  M6_RS06215 (M6_Spy1238) - 1230106..1230312 (-) 207 WP_002990074.1 hypothetical protein -
  M6_RS10020 (M6_Spy1239) - 1230321..1230461 (-) 141 WP_002988354.1 hypothetical protein -
  M6_RS06220 (M6_Spy1240) - 1230458..1230691 (-) 234 WP_002988350.1 hypothetical protein -
  M6_RS06225 (M6_Spy1241) - 1230672..1231058 (-) 387 WP_002990076.1 DnaD domain-containing protein -
  M6_RS06230 (M6_Spy1242) - 1231133..1231885 (+) 753 Protein_1212 tyrosine-type recombinase/integrase -
  M6_RS06235 (M6_Spy1243) - 1231974..1232249 (-) 276 WP_002983920.1 HU family DNA-binding protein -
  M6_RS06240 (M6_Spy1244) - 1232348..1232935 (-) 588 WP_002989129.1 YpmS family protein -
  M6_RS06245 (M6_Spy1245) - 1232913..1233755 (-) 843 WP_011888746.1 SGNH/GDSL hydrolase family protein -

Sequence

Protein


Download         Length: 60 a.a.        Molecular weight: 6936.91 Da        Isoelectric Point: 4.1954

>NTDB_id=23458 M6_RS06005 WP_011184726.1 1200261..1200443(-) (prx) [Streptococcus pyogenes MGAS10394]
MLTYDEFKQAIDNGYITADTVMIVRKNGQIFDYVLPNEKIKNGEIVTDEKVEEVLVELSR

Nucleotide


Download         Length: 183 bp        

>NTDB_id=23458 M6_RS06005 WP_011184726.1 1200261..1200443(-) (prx) [Streptococcus pyogenes MGAS10394]
ATGCTAACATACGACGAATTTAAACAAGCAATTGACAATGGATATATCACAGCAGACACAGTAATGATCGTGCGCAAGAA
CGGACAGATTTTTGATTATGTGTTGCCGAATGAGAAGATAAAGAATGGAGAAATTGTGACAGACGAAAAAGTGGAAGAGG
TGCTGGTGGAGCTTTCGAGATAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  prx Streptococcus pyogenes MGAS315

98.333

100

0.983
  prx Streptococcus pyogenes MGAS8232

86.667

100

0.867
  prx Streptococcus pyogenes MGAS315

78.333

100

0.783
  prx Streptococcus pyogenes MGAS315

75

100

0.75
  prx Streptococcus pyogenes MGAS315

83.721

71.667

0.6
  prx Streptococcus pyogenes MGAS315

85.366

68.333

0.583
  prx Streptococcus pyogenes MGAS315

71.429

70

0.5

Multiple sequence alignment