Detailed information NTG0022557

Bioinformatically predicted

Overview

• Name: clpP
• Type: Regulator
• Locus tag: SPYM18_RS02010
• Genome accession: NC_003485
• Coordinates: 366963..367553 (+)
• Length: 196 a.a.
• NCBI ID: WP_002985850.1
• Uniprot ID: A0A9X9QW05
• Organism: Streptococcus pyogenes MGAS8232
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 361963..372553

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPYM18_RS01995 (spyM18_0440)	-	362776..364221 (-)	1446	WP_002990934.1	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase	-
SPYM18_RS02000 (spyM18_0442)	-	364309..365943 (+)	1635	WP_011017418.1	putative polysaccharide biosynthesis protein	-
SPYM18_RS02005 (spyM18_0443)	upp	366110..366739 (+)	630	WP_002985854.1	uracil phosphoribosyltransferase	-
SPYM18_RS02010 (spyM18_0446)	clpP	366963..367553 (+)	591	WP_002985850.1	ATP-dependent Clp protease proteolytic subunit	Regulator
SPYM18_RS02015 (spyM18_0447)	-	368048..368323 (+)	276	WP_002985847.1	YlbG family protein	-
SPYM18_RS02020 (spyM18_0449)	tmk	368572..369207 (+)	636	WP_011017420.1	dTMP kinase	-
SPYM18_RS02025 (spyM18_0450)	-	369225..370100 (+)	876	WP_011017421.1	DNA polymerase III subunit delta'	-
SPYM18_RS02030 (spyM18_0451)	-	370119..370358 (+)	240	WP_011017422.1	hypothetical protein	-
SPYM18_RS02035 (spyM18_0455)	yabA	370763..371086 (+)	324	WP_011017424.1	DNA replication initiation control protein YabA	-
SPYM18_RS02040 (spyM18_0456)	rsmI	371091..371954 (+)	864	WP_011017425.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-
SPYM18_RS02045 (spyM18_0457)	-	371981..372373 (+)	393	WP_011017426.1	DUF5684 domain-containing protein	-

Sequence

Protein

• Length: 196 a.a.
• Molecular weight: 21648.88 Da
• Isoelectric Point: 5.2834

>NTDB_id=22557 SPYM18_RS02010 WP_002985850.1 366963..367553(+) (clpP) [Streptococcus pyogenes MGAS8232]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDNTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGTKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRHRLEKILAQNAGK
TIKQIHKDAERDYWMSAEETLAYGFIDEIMENNELK

Nucleotide

• Length: 591 bp

>NTDB_id=22557 SPYM18_RS02010 WP_002985850.1 366963..367553(+) (clpP) [Streptococcus pyogenes MGAS8232]
ATGATTCCTGTTGTTATTGAACAAACTAGCCGTGGAGAACGTTCTTATGACATTTATTCACGTTTATTAAAAGACCGTAT
TATCATGTTAACAGGGCCTGTCGAAGACAACATGGCCAACTCTGTCATAGCGCAGCTCTTATTCCTTGACGCGCAAGACA
ACACTAAAGATATCTACCTATATGTCAACACACCAGGTGGCTCTGTCTCAGCAGGCTTGGCTATTGTCGATACCATGAAC
TTTATCAAGGCCGATGTGCAAACTATTGTCATGGGTATGGCAGCTTCTATGGGGACAGTCATTGCTTCATCAGGAACAAA
AGGCAAACGCTTTATGTTACCAAATGCAGAGTATATGATCCACCAGCCAATGGGTGGCACAGGCGGTGGCACGCAACAAA
CGGATATGGCTATCGCAGCAGAACATCTCTTAAAAACACGTCACCGTTTAGAAAAAATCTTAGCGCAAAATGCTGGAAAA
ACGATTAAACAAATCCATAAAGATGCTGAGCGTGATTATTGGATGAGTGCTGAAGAAACCTTGGCTTACGGTTTCATTGA
TGAAATCATGGAAAACAACGAACTAAAATAA

Domains

Predicted by InterProScan.

• Clp protease (CLP_protease) (11-192)

3D structure

• AlphaFold DB: A0A9X9QW05

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpP	Streptococcus pyogenes MGAS315	100	100	1
clpP	Streptococcus pyogenes JRS4	100	100	1
clpP	Streptococcus mutans UA159	90.816	100	0.908
clpP	Streptococcus pneumoniae Rx1	90.769	99.49	0.903
clpP	Streptococcus pneumoniae D39	90.769	99.49	0.903
clpP	Streptococcus pneumoniae R6	90.769	99.49	0.903
clpP	Streptococcus pneumoniae TIGR4	90.769	99.49	0.903
clpP	Streptococcus thermophilus LMG 18311	89.796	100	0.898
clpP	Streptococcus thermophilus LMD-9	89.796	100	0.898
clpP	Lactococcus lactis subsp. lactis strain DGCC12653	86.224	100	0.862
clpP	Lactococcus lactis subsp. cremoris KW2	85.714	100	0.857
clpP	Bacillus subtilis subsp. subtilis str. 168	57.143	100	0.571
clpP	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	56.995	98.469	0.561