Detailed information NTG0223279

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: A6J87_RS09670
• Genome accession: NZ_CP020451
• Coordinates: 2011583..2012257 (+)
• Length: 224 a.a.
• NCBI ID: WP_049546057.1
• Uniprot ID: A0A1V0H9R4
• Organism: Streptococcus salivarius strain FDAARGOS_259
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 2006583..2017257

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A6J87_RS09650 (A6J87_09590)	-	2007697..2008269 (-)	573	WP_021144028.1	ECF transporter S component	-
A6J87_RS09655 (A6J87_09595)	coaC	2008298..2008843 (-)	546	WP_070577368.1	phosphopantothenoylcysteine decarboxylase	-
A6J87_RS09660 (A6J87_09600)	-	2008836..2009519 (-)	684	WP_013990463.1	phosphopantothenate--cysteine ligase	-
A6J87_RS09665 (A6J87_09605)	-	2009714..2011384 (+)	1671	WP_013990464.1	formate--tetrahydrofolate ligase	-
A6J87_RS09670 (A6J87_09610)	ciaR	2011583..2012257 (+)	675	WP_049546057.1	response regulator transcription factor	Regulator
A6J87_RS09675 (A6J87_09615)	ciaH	2012247..2013662 (+)	1416	WP_080611984.1	cell wall metabolism sensor histidine kinase WalK	Regulator
A6J87_RS09680 (A6J87_09620)	rpsT	2013747..2013983 (-)	237	WP_037597891.1	30S ribosomal protein S20	-
A6J87_RS09685 (A6J87_09625)	coaA	2014053..2014973 (-)	921	WP_037597889.1	type I pantothenate kinase	-
A6J87_RS09690 (A6J87_09630)	-	2015087..2015677 (+)	591	WP_073951006.1	class I SAM-dependent methyltransferase	-
A6J87_RS09695 (A6J87_09635)	-	2015674..2016951 (+)	1278	WP_080611985.1	pyrimidine-nucleoside phosphorylase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25347.99 Da
• Isoelectric Point: 4.2845

>NTDB_id=223279 A6J87_RS09670 WP_049546057.1 2011583..2012257(+) (ciaR) [Streptococcus salivarius strain FDAARGOS_259]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELRDKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=223279 A6J87_RS09670 WP_049546057.1 2011583..2012257(+) (ciaR) [Streptococcus salivarius strain FDAARGOS_259]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCCAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
TATGCAGGTCTTTGATGGTGATGAAGGCCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACTTAATGT
TACCTGAAAAAGATGGTTTCACTGTTCTTAGAGAATTACGTGATAAAGGTGTAACAACTCCTGTACTTATCATGACTGCC
AAGGAAAGTCTAGACGATAAGGGACATGGTTTTGAACTTGGTGCGGATGACTATCTAACCAAACCTTTCTACTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTTTTGAAACGCTCTGGTAAATTTGACCAAAACACACTTTCTTTCGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGTGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAT
TTCTTACAAAATCAGAATGTGATCTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACGGT
ATCAGTTGTTGAAGTATACGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGACTTTGCTGCCAACCTCCAAACCTTGA
GAAGTGTGGGGTACATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

3D structure

• AlphaFold DB: A0A1V0H9R4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae D39	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae R6	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae TIGR4	86.996	99.554	0.866
ciaR	Streptococcus mutans UA159	86.161	100	0.862
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.222	100	0.384
vicR	Streptococcus mutans UA159	35.983	100	0.384
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362