Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   A6J31_RS05010 Genome accession   NZ_CP020431
Coordinates   830203..830877 (-) Length   224 a.a.
NCBI ID   WP_002891134.1    Uniprot ID   J7TS49
Organism   Streptococcus sp. FDAARGOS_192     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 825203..835877
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A6J31_RS04985 (A6J31_04940) - 825517..826794 (-) 1278 WP_080610581.1 pyrimidine-nucleoside phosphorylase -
  A6J31_RS04990 (A6J31_04945) - 826791..827381 (-) 591 WP_013990468.1 class I SAM-dependent methyltransferase -
  A6J31_RS04995 (A6J31_04950) coaA 827494..828414 (+) 921 WP_013990467.1 type I pantothenate kinase -
  A6J31_RS05000 (A6J31_04955) rpsT 828484..828720 (+) 237 WP_004182129.1 30S ribosomal protein S20 -
  A6J31_RS05005 (A6J31_04960) ciaH 828798..830213 (-) 1416 WP_080610582.1 sensor histidine kinase Regulator
  A6J31_RS05010 (A6J31_04965) ciaR 830203..830877 (-) 675 WP_002891134.1 response regulator transcription factor Regulator
  A6J31_RS05015 (A6J31_04970) - 831076..832746 (-) 1671 WP_013990464.1 formate--tetrahydrofolate ligase -
  A6J31_RS05020 (A6J31_04975) - 832941..833624 (+) 684 WP_013990463.1 phosphopantothenate--cysteine ligase -
  A6J31_RS05025 (A6J31_04980) coaC 833617..834162 (+) 546 WP_013990462.1 phosphopantothenoylcysteine decarboxylase -
  A6J31_RS05030 (A6J31_04985) - 834191..834763 (+) 573 WP_022496698.1 ECF transporter S component -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25362.02 Da        Isoelectric Point: 4.2897

>NTDB_id=222872 A6J31_RS05010 WP_002891134.1 830203..830877(-) (ciaR) [Streptococcus sp. FDAARGOS_192]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide


Download         Length: 675 bp        

>NTDB_id=222872 A6J31_RS05010 WP_002891134.1 830203..830877(-) (ciaR) [Streptococcus sp. FDAARGOS_192]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCCAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
GATGCAAGTCTTTGATGGAGATGAAGGCCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACCTTATGT
TGCCTGAAAAAGATGGTTTCACTGTTCTTAGAGAATTACGTGAAAAAGGTGTAACAACTCCTGTACTTATCATGACGGCT
AAGGAAAGTCTAGACGATAAGGGGCACGGCTTTGAACTGGGTGCAGATGACTATCTAACCAAACCTTTCTATTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTTTTGAAACGCTCTGGTAAATTTGACCAAAACACACTTTCTTTTGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGGGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAAAACGTGATTTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACGGT
ATCAGTTGTCGAGGTTTATGTTTCTAAAATTCGTAAGAAACTTAAAGGAACGGACTTTGCTGCCAACCTCCAAACCTTGA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB J7TS49

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

87.444

99.554

0.871
  ciaR Streptococcus pneumoniae D39

87.444

99.554

0.871
  ciaR Streptococcus pneumoniae R6

87.444

99.554

0.871
  ciaR Streptococcus pneumoniae TIGR4

87.444

99.554

0.871
  ciaR Streptococcus mutans UA159

86.607

100

0.866
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.222

100

0.384
  vicR Streptococcus mutans UA159

35.983

100

0.384
  micA Streptococcus pneumoniae Cp1015

34.322

100

0.362

Multiple sequence alignment