Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   BWR56_RS04940 Genome accession   NZ_CP019562
Coordinates   1022473..1023180 (-) Length   235 a.a.
NCBI ID   WP_049505846.1    Uniprot ID   -
Organism   Streptococcus oralis strain S.MIT/ORALIS-351     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1017473..1028180
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BWR56_RS04920 (BWR56_0976) - 1019074..1019421 (+) 348 WP_076984561.1 PedC/BrcD family bacteriocin maturation disulfide isomerase -
  BWR56_RS04925 (BWR56_0977) - 1019459..1020232 (-) 774 WP_076984562.1 potassium channel family protein -
  BWR56_RS04930 (BWR56_0978) vicX 1020320..1021129 (-) 810 WP_049505844.1 MBL fold metallo-hydrolase Regulator
  BWR56_RS04935 (BWR56_0979) micB 1021131..1022480 (-) 1350 WP_049505845.1 cell wall metabolism sensor histidine kinase VicK Regulator
  BWR56_RS04940 (BWR56_0980) micA 1022473..1023180 (-) 708 WP_049505846.1 response regulator YycF Regulator
  BWR56_RS04945 (BWR56_0981) mutY 1023237..1024415 (-) 1179 WP_049505847.1 A/G-specific adenine glycosylase -
  BWR56_RS04950 (BWR56_0982) pta 1024498..1025472 (-) 975 WP_076984563.1 phosphate acetyltransferase -
  BWR56_RS04955 (BWR56_0983) - 1025516..1026412 (-) 897 WP_049505849.1 RluA family pseudouridine synthase -
  BWR56_RS04960 (BWR56_0984) - 1026409..1027227 (-) 819 WP_000799063.1 NAD kinase -
  BWR56_RS04965 (BWR56_0985) - 1027211..1027882 (-) 672 WP_000151555.1 GTP pyrophosphokinase -

Sequence

Protein


Download         Length: 235 a.a.        Molecular weight: 26991.83 Da        Isoelectric Point: 4.6133

>NTDB_id=216324 BWR56_RS04940 WP_049505846.1 1022473..1023180(-) (micA) [Streptococcus oralis strain S.MIT/ORALIS-351]
MKKILIVDDEKPISDIIKFNMAKEGYEVVTAFNGREAIDLFEAEQPDIIILDLMLPEIDGLEVAKAIRKTSSVPIIMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRTDLVSVDSQESDEKKTQPLQIGDLEIVPDAYVAKKYGEELDL
THREFELLYHLASHIGQVITREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMRNND

Nucleotide


Download         Length: 708 bp        

>NTDB_id=216324 BWR56_RS04940 WP_049505846.1 1022473..1023180(-) (micA) [Streptococcus oralis strain S.MIT/ORALIS-351]
ATGAAAAAAATATTAATTGTAGATGATGAGAAACCAATCTCAGATATTATTAAGTTTAATATGGCCAAGGAAGGTTATGA
AGTCGTGACAGCCTTCAATGGTCGTGAGGCAATCGACCTATTTGAAGCAGAGCAACCAGATATTATTATCCTCGACTTGA
TGCTACCTGAAATTGATGGTTTAGAAGTTGCTAAAGCTATTCGTAAGACTAGTAGCGTGCCGATTATCATGCTATCAGCT
AAGGATAGCGAGTTTGACAAGGTTATTGGTTTAGAGTTAGGTGCAGATGATTATGTTACAAAACCTTTCTCAAACCGTGA
ATTGCAGGCTCGTGTCAAGGCCCTGCTTCGTCGTACAGACCTGGTTTCTGTGGATAGCCAAGAGTCTGATGAGAAGAAGA
CGCAGCCTTTACAAATTGGTGATTTGGAAATCGTTCCAGATGCTTACGTGGCTAAGAAATATGGTGAGGAGTTAGATTTG
ACCCACCGCGAGTTTGAACTCTTGTATCACTTGGCATCTCATATTGGTCAAGTGATTACGCGTGAACACTTGCTTGAGAC
TGTATGGGGTTATGACTATTTTGGTGATGTTCGTACAGTGGACGTGACCATTAGACGCTTGCGTGAGAAAATAGAAGATA
CTCCAAGTCGTCCAGAGTACATTCTCACACGTCGTGGTGTTGGATACTATATGAGAAATAATGATTGA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(155-230)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

91.88

99.574

0.915
  vicR Streptococcus mutans UA159

77.447

100

0.774
  covR Streptococcus salivarius strain HSISS4

43.29

98.298

0.426
  covR Lactococcus lactis subsp. lactis strain DGCC12653

42.857

98.298

0.421
  scnR Streptococcus mutans UA159

36.752

99.574

0.366

Multiple sequence alignment