Detailed information NTG0210875

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: BUM80_RS12070
• Genome accession: NZ_CP018838
• Coordinates: 35831..36418 (-)
• Length: 195 a.a.
• NCBI ID: WP_001810228.1
• Uniprot ID: A0A380LSF4
• Organism: Streptococcus pneumoniae strain 11A
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 30831..41418

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BUM80_RS00165 (BUM80_00160)	-	31295..32635 (+)	1341	WP_001017638.1	sensor histidine kinase	-
BUM80_RS00170 (BUM80_00165)	blpC	32677..32832 (-)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
BUM80_RS00175 (BUM80_00170)	-	32889..34250 (-)	1362	WP_001069091.1	bacteriocin secretion accessory protein	-
BUM80_RS00180 (BUM80_00175)	comA/nlmT	34261..35937 (-)	1677	WP_196299874.1	peptide cleavage/export ABC transporter	Regulator
BUM80_RS12070 (BUM80_00180)	comA/nlmT	35831..36418 (-)	588	WP_001810228.1	cysteine peptidase family C39 domain-containing protein	Regulator
BUM80_RS00185 (BUM80_00185)	blpI	36700..36897 (+)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
BUM80_RS00195 (BUM80_00195)	blpJ	37364..37633 (+)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
BUM80_RS00200 (BUM80_00200)	blpU	37702..37932 (+)	231	WP_000379964.1	bacteriocin-like peptide BlpU	-
BUM80_RS00205 (BUM80_00205)	-	37935..38054 (+)	120	WP_000346298.1	PncF family bacteriocin immunity protein	-
BUM80_RS00210 (BUM80_00210)	-	38351..38515 (+)	165	WP_000727118.1	hypothetical protein	-
BUM80_RS00215 (BUM80_00215)	-	38512..38916 (+)	405	WP_000846944.1	hypothetical protein	-
BUM80_RS00220	-	39114..39918 (+)	805	Protein_39	IS5 family transposase	-
BUM80_RS00225 (BUM80_00230)	blpM	40068..40322 (+)	255	WP_000379879.1	two-peptide bacteriocin subunit BlpM	-
BUM80_RS00230 (BUM80_00235)	blpN	40338..40541 (+)	204	WP_001099492.1	two-peptide bacteriocin subunit BlpN	-
BUM80_RS00240 (BUM80_00245)	cipB	40785..40934 (+)	150	WP_001809846.1	bacteriocin-like peptide BlpO	Regulator
BUM80_RS00245 (BUM80_00250)	-	41038..41157 (+)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22369.84 Da
• Isoelectric Point: 9.7306

>NTDB_id=210875 BUM80_RS12070 WP_001810228.1 35831..36418(-) (comA/nlmT) [Streptococcus pneumoniae strain 11A]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLR

Nucleotide

• Length: 588 bp

>NTDB_id=210875 BUM80_RS12070 WP_001810228.1 35831..36418(-) (comA/nlmT) [Streptococcus pneumoniae strain 11A]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTAGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: A0A380LSF4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497