Detailed information NTG0206854

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: BSR19_RS06170
• Genome accession: NZ_CP018187
• Coordinates: 1250688..1251362 (-)
• Length: 224 a.a.
• NCBI ID: WP_049546057.1
• Uniprot ID: A0A1V0H9R4
• Organism: Streptococcus salivarius strain ICDC2
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1245688..1256362

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BSR19_RS06145 (BSR19_06220)	-	1245994..1247271 (-)	1278	WP_156246786.1	pyrimidine-nucleoside phosphorylase	-
BSR19_RS06150 (BSR19_06225)	-	1247268..1247858 (-)	591	WP_073686336.1	class I SAM-dependent methyltransferase	-
BSR19_RS06155 (BSR19_06230)	coaA	1247972..1248892 (+)	921	WP_156246787.1	type I pantothenate kinase	-
BSR19_RS06160 (BSR19_06235)	rpsT	1248962..1249198 (+)	237	WP_037597891.1	30S ribosomal protein S20	-
BSR19_RS06165 (BSR19_06240)	ciaH	1249283..1250698 (-)	1416	WP_156246788.1	sensor histidine kinase	Regulator
BSR19_RS06170 (BSR19_06245)	ciaR	1250688..1251362 (-)	675	WP_049546057.1	response regulator transcription factor	Regulator
BSR19_RS06175 (BSR19_06250)	-	1251561..1253231 (-)	1671	WP_002891135.1	formate--tetrahydrofolate ligase	-
BSR19_RS06180 (BSR19_06255)	-	1253425..1254108 (+)	684	WP_156246789.1	phosphopantothenate--cysteine ligase	-
BSR19_RS06185 (BSR19_06260)	coaC	1254101..1254646 (+)	546	WP_156246790.1	phosphopantothenoylcysteine decarboxylase	-
BSR19_RS06190 (BSR19_06265)	-	1254675..1255247 (+)	573	WP_156246791.1	ECF transporter S component	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25347.99 Da
• Isoelectric Point: 4.2845

>NTDB_id=206854 BSR19_RS06170 WP_049546057.1 1250688..1251362(-) (ciaR) [Streptococcus salivarius strain ICDC2]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELRDKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=206854 BSR19_RS06170 WP_049546057.1 1250688..1251362(-) (ciaR) [Streptococcus salivarius strain ICDC2]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCCAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
TATGCAGGTCTTTGATGGTGATGAAGGCCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACTTAATGT
TACCTGAAAAAGATGGTTTCACTGTTCTTAGAGAATTACGTGATAAAGGTGTAACAACTCCTGTACTTATCATGACTGCT
AAGGAAAGTCTAGACGATAAGGGACATGGTTTTGAACTTGGTGCGGATGACTATCTAACCAAACCTTTCTACTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTTTTGAAACGCTCTGGTAAATTTGACCAAAACACACTTTCTTTTGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGGGATAAAGAGGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAT
TTCTTACAAAATCAGAATGTTATCTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACTACGGT
ATCAGTTGTTGAAGTATACGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGACTTTGCTGCCAACCTCCAAACCTTGA
GAAGTGTGGGGTACATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

3D structure

• AlphaFold DB: A0A1V0H9R4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae D39	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae R6	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae TIGR4	86.996	99.554	0.866
ciaR	Streptococcus mutans UA159	86.161	100	0.862
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.222	100	0.384
vicR	Streptococcus mutans UA159	35.983	100	0.384
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362