Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SMA_1065 Genome accession   HE613569
Coordinates   1046385..1047059 (-) Length   224 a.a.
NCBI ID   CCF02356.1    Uniprot ID   -
Organism   Streptococcus macedonicus ACA-DC 198     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1041385..1052059
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMA_1059 deoC 1041812..1042474 (-) 663 CCF02350.1 Deoxyribose-phosphate aldolase -
  SMA_1060 - 1042705..1042821 (-) 117 CCF02351.1 Hypothetical protein -
  SMA_1061 - 1042965..1043558 (-) 594 CCF02352.1 Ribosomal RNA small subunit methyltransferase C -
  SMA_1062 coaA 1043672..1044592 (+) 921 CCF02353.1 Pantothenate kinase -
  SMA_1063 rpsT 1044682..1044918 (+) 237 CCF02354.1 SSU ribosomal protein S20p -
  SMA_1064 ciaH 1045055..1046395 (-) 1341 CCF02355.1 Two component system sensor histidine kinase CiaH Regulator
  SMA_1065 ciaR 1046385..1047059 (-) 675 CCF02356.1 Two component system response regulator CiaR Regulator
  SMA_1066 pepN 1047257..1049800 (-) 2544 CCF02357.1 Lysyl aminopeptidase -
  SMA_1067 - 1049973..1050077 (-) 105 Protein_1066 Hypothetical protein -
  SMA_1068 tnpA 1050101..1051357 (+) 1257 CCF02359.1 putative transposase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25525.27 Da        Isoelectric Point: 4.3477

>NTDB_id=20353 SMA_1065 CCF02356.1 1046385..1047059(-) (ciaR) [Streptococcus macedonicus ACA-DC 198]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVSTPVLIMTA
KESLGDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKYNFNTLSYEELTVDTSTNTTIANGKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKDTTFAKNLQTLRSVGYILKNVE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=20353 SMA_1065 CCF02356.1 1046385..1047059(-) (ciaR) [Streptococcus macedonicus ACA-DC 198]
ATGATTAAGATATTATTAGTAGAGGATGATTTGAGTCTATCTAATTCCATTTTTGATTTTTTAGATGATTTTGCAGATGT
TATGCAGGTATTTGACGGCGAAGAAGGTTTGTACGAAGCTGAAAGTGGCGTATATGACCTTATTTTGCTTGACTTGATGT
TACCTGAAAAAGATGGTTTCCAAGTGCTTAAAGAGTTACGAGAAAAAGGTGTGTCAACACCAGTACTTATTATGACTGCC
AAAGAAAGTCTTGGTGATAAGGGACATGGTTTCGAGTTGGGAGCAGATGATTATCTTACTAAACCATTTTACCTTGAAGA
GCTAAAAATGCGTATTCAAGCTCTTTTAAAACGTTCGGGTAAATACAACTTCAATACCTTATCTTATGAAGAATTAACCG
TTGACACTTCTACCAATACAACAATAGCTAACGGTAAAGAAGTCGAGCTGCTTGGTAAAGAATTTGATTTGTTGGTTTAT
TTCTTACAAAATCAAAATGTTATTTTACCAAAATCACAAATTTTTGACCGTATTTGGGGCTTTGATAGTGATACAACGAT
TTCGGTTGTTGAAGTTTACGTTTCAAAAATTCGAAAAAAACTCAAAGACACCACCTTTGCCAAAAATCTTCAAACCCTAC
GGAGTGTAGGTTATATTCTGAAAAATGTTGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

92.377

99.554

0.92
  ciaR Streptococcus pneumoniae Rx1

86.607

100

0.866
  ciaR Streptococcus pneumoniae D39

86.607

100

0.866
  ciaR Streptococcus pneumoniae R6

86.607

100

0.866
  ciaR Streptococcus pneumoniae TIGR4

86.607

100

0.866
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.938

100

0.393
  vicR Streptococcus mutans UA159

36.017

100

0.379
  micA Streptococcus pneumoniae Cp1015

35.193

100

0.366

Multiple sequence alignment