Detailed information NTG0020249

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: SPG_2188
• Genome accession: CP001015
• Coordinates: 2076940..2078121 (+)
• Length: 393 a.a.
• NCBI ID: ACF55645.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae G54
• Function: degrading CSP; selective degradation of ComEA and ComEC (predicted from homology) Competence regulation

Genomic Context

Location: 2071940..2083121

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPG_2179	-	2072045..2072812 (-)	768	ACF56436.1	hypothetical protein	-
SPG_2180	-	2072991..2073533 (+)	543	ACF56205.1	conserved hypothetical protein	-
SPG_2183	comE	2073776..2074528 (-)	753	ACF55408.1	ComE response regulator TCS12	Regulator
SPG_2184	comD/comD1	2074525..2075850 (-)	1326	ACF56316.1	ComD histidine kinase TCS12	Regulator
SPG_2185	comC/comC1	2075871..2075996 (-)	126	ACF56795.1	competence-stimulating peptide type 1, CSP1	Regulator
SPG_2187	-	2076278..2076757 (-)	480	ACF55146.1	conserved hypothetical protein	-
SPG_2188	htrA	2076940..2078121 (+)	1182	ACF55645.1	serine protease	Regulator
SPG_2189	spo0J	2078179..2078937 (+)	759	ACF55136.1	ParB-like partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41861.43 Da
• Isoelectric Point: 6.8902

>NTDB_id=20249 SPG_2188 ACF55645.1 2076940..2078121(+) (htrA) [Streptococcus pneumoniae G54]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLRSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSXKLNKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=20249 SPG_2188 ACF55645.1 2076940..2078121(+) (htrA) [Streptococcus pneumoniae G54]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTAGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAGATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTANCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTGA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

• PDZ domain (PDZ_2) (289-384)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus pneumoniae Rx1	99.237	100	0.992
htrA	Streptococcus pneumoniae D39	99.237	100	0.992
htrA	Streptococcus pneumoniae R6	99.237	100	0.992
htrA	Streptococcus pneumoniae TIGR4	99.237	100	0.992
htrA	Streptococcus mitis NCTC 12261	96.947	100	0.969
htrA	Streptococcus gordonii str. Challis substr. CH1	66.667	100	0.672
htrA	Streptococcus mutans UA159	54.569	100	0.547