Detailed information NTG0185399

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: A9497_RS07500
• Genome accession: NZ_CP016026
• Coordinates: 1425097..1425996 (+)
• Length: 299 a.a.
• NCBI ID: WP_014607953.1
• Uniprot ID: A0AAN1ZWJ0
• Organism: Streptococcus thermophilus strain KLDS SM
• Function: activate transcription of comX; activate transcription of comS (predicted from homology) Competence regulation

Genomic Context

Location: 1420097..1430996

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A9497_RS07480 (A9497_07480)	trkA	1421233..1422582 (-)	1350	WP_024704181.1	Trk system potassium transporter TrkA	-
A9497_RS07485 (A9497_07485)	-	1422842..1423381 (+)	540	WP_370869438.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
A9497_RS07490 (A9497_07490)	-	1423692..1424249 (+)	558	WP_024704183.1	ECF transporter S component	-
A9497_RS07495 (A9497_07495)	-	1424252..1424902 (+)	651	WP_011225447.1	phosphatase PAP2 family protein	-
A9497_RS07500 (A9497_07500)	comR	1425097..1425996 (+)	900	WP_014607953.1	helix-turn-helix domain-containing protein	Regulator
A9497_RS11410	-	1426234..1426665 (+)	432	Protein_1397	cysteine peptidase family C39 domain-containing protein	-
A9497_RS11415	-	1426695..1427411 (+)	717	Protein_1398	ABC transporter transmembrane domain-containing protein	-
A9497_RS11420 (A9497_07520)	comA	1427433..1427642 (+)	210	WP_002946147.1	hypothetical protein	Regulator
A9497_RS07525 (A9497_07525)	-	1427697..1428265 (+)	569	Protein_1400	ATP-binding cassette domain-containing protein	-
A9497_RS07530 (A9497_07530)	-	1428373..1428705 (+)	333	WP_024704184.1	DUF805 domain-containing protein	-
A9497_RS11425	-	1428851..1429330 (-)	480	WP_224107489.1	DUF4153 domain-containing protein	-
A9497_RS11430	-	1429772..1430143 (-)	372	WP_224107488.1	hypothetical protein	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 35289.70 Da
• Isoelectric Point: 5.0061

>NTDB_id=185399 A9497_RS07500 WP_014607953.1 1425097..1425996(+) (comR) [Streptococcus thermophilus strain KLDS SM]
MNIKDSIGLRIKTERERQQMSREVLCLDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYE
MKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFST
NDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIENS
QLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKAGKLADGL

Nucleotide

• Length: 900 bp

>NTDB_id=185399 A9497_RS07500 WP_014607953.1 1425097..1425996(+) (comR) [Streptococcus thermophilus strain KLDS SM]
TTGAACATAAAAGACAGCATTGGACTAAGAATCAAAACTGAGCGTGAACGCCAACAGATGTCACGTGAAGTGCTATGTTT
AGATGGTGCGGAATTGACTGTTCGCCAGTTAATTCGTATTGAAAAGGGGGAGTCTCTCCCGTCTTTAGATAGATTATCGT
ATATTGCTAAACGTTTAGGAAAAAGTATGACAGAGTTATTGGATCAAGACAATATTACCATTCCTGACGAATATTATGAA
ATGAAGAATCGTTTGATTAAGTTTCCAACGTACAGAAACCCTGACAGAATAAAGTCTAAACTTACTTTGATTGAGGAAGT
CTATGAGAAATTTTTTGATATTCTTCCAGAAGAAGAATTATTAACTCTAGACATTCTCGAAAATATATTGAGTTTTACTA
GCTGGGAGGAGAGTCCAAAAGTTGAGGAGATATATGAAGACTTGTTTGAACAAGTCAAAAGGAAGAGGAAATTCTCAACT
AACGATTTATTAGTCATTGACTATTATTTCTTTCATCTTTATGGGAGAAAACAGTATGACAAAAAACTATTTGAAAGAAT
TATAAAGAGAGTATTAAATCAGGAAATTTGGACAGATGATGTTTACAATATTGTTTTATTTAATGATTTGATGGCTATTG
CTGCTTTAAAGATTTTTCACAATTCCTTCTCAGACTTCTTAACAGTTGTGGATAAAGCCTTAGCTGTCATAGAAAACTCA
CAATTATATAGCTACAAGCCTAGTGTTTTTGTACTTAAGGCTAAATATGAACTTCTGCATAAAGAAAACAAGAAAGAGGC
TGCAGAGAATTATGATAAGGCCATAATGTTTGCTTCCGTTTTGGAAGACTCGGTTTTAGAGGAAAGTATAAAGGCAGGAA
AATTGGCAGATGGTTTATAG

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (11-66)

• ComR tetratricopeptide (ComR_TPR) (75-292)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus thermophilus LMG 18311	99.666	100	0.997
comR	Streptococcus thermophilus LMD-9	98.997	100	0.99
comR	Streptococcus salivarius strain HSISS4	94.983	100	0.95
comR	Streptococcus salivarius SK126	94.314	100	0.943
comR/comR2	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421
comR/comR1	Streptococcus sobrinus strain NIDR 6715-7	41.806	100	0.418