Detailed information NTG0178314

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: V471_RS07060
• Genome accession: NZ_CP015283
• Coordinates: 1513476..1514150 (+)
• Length: 224 a.a.
• NCBI ID: WP_049546057.1
• Uniprot ID: A0A1V0H9R4
• Organism: Streptococcus salivarius strain ATCC 25975
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1508476..1519150

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
V471_RS07035 (V471_06935)	-	1508964..1509524 (-)	561	WP_004182060.1	ECF transporter S component	-
V471_RS07040 (V471_06940)	-	1509591..1510163 (-)	573	WP_084871334.1	ECF transporter S component	-
V471_RS07045 (V471_06945)	coaC	1510192..1510737 (-)	546	WP_084871335.1	phosphopantothenoylcysteine decarboxylase	-
V471_RS07050 (V471_06950)	-	1510730..1511413 (-)	684	WP_084871336.1	phosphopantothenate--cysteine ligase	-
V471_RS07055 (V471_06955)	-	1511607..1513277 (+)	1671	WP_084871337.1	formate--tetrahydrofolate ligase	-
V471_RS07060 (V471_06960)	ciaR	1513476..1514150 (+)	675	WP_049546057.1	response regulator transcription factor	Regulator
V471_RS07065 (V471_06965)	ciaH	1514140..1515555 (+)	1416	WP_004182392.1	sensor histidine kinase	Regulator
V471_RS07070 (V471_06970)	rpsT	1515633..1515869 (-)	237	WP_004182129.1	30S ribosomal protein S20	-
V471_RS07075 (V471_06975)	coaA	1515939..1516859 (-)	921	WP_004182393.1	type I pantothenate kinase	-
V471_RS07080 (V471_06980)	-	1516972..1517562 (+)	591	WP_004182394.1	class I SAM-dependent methyltransferase	-
V471_RS07085 (V471_06985)	-	1517559..1518836 (+)	1278	WP_004182395.1	pyrimidine-nucleoside phosphorylase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25347.99 Da
• Isoelectric Point: 4.2845

>NTDB_id=178314 V471_RS07060 WP_049546057.1 1513476..1514150(+) (ciaR) [Streptococcus salivarius strain ATCC 25975]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELRDKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=178314 V471_RS07060 WP_049546057.1 1513476..1514150(+) (ciaR) [Streptococcus salivarius strain ATCC 25975]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
GATGCAGGTATTTGATGGAGATGAAGGTCTCTACGAAGCTGAAAGTGGCGTTTATGATTTGATTCTTTTAGACTTAATGT
TGCCTGAAAAAGATGGTTTCACTGTTCTTAGAGAATTACGTGACAAAGGTGTAACAACTCCTGTACTTATCATGACGGCT
AAGGAAAGTCTAGATGATAAGGGCCACGGCTTTGAACTTGGTGCAGATGACTACCTAACTAAGCCTTTCTATTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTCTTGAAACGCTCTGGTAAATTTGACCAAAACACACTTTCTTTTGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGGGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAAAATGTCATCTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACAGT
ATCAGTTGTCGAGGTTTATGTTTCTAAAATTCGTAAGAAACTAAAAGGAACAGACTTTGCTGCCAACCTCCAAACCTTGA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

3D structure

• AlphaFold DB: A0A1V0H9R4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae D39	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae R6	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae TIGR4	86.996	99.554	0.866
ciaR	Streptococcus mutans UA159	86.161	100	0.862
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.222	100	0.384
vicR	Streptococcus mutans UA159	35.983	100	0.384
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362