Detailed information NTG0178195

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: NX99_RS01150
• Genome accession: NZ_CP015282
• Coordinates: 346653..347327 (+)
• Length: 224 a.a.
• NCBI ID: WP_002891134.1
• Uniprot ID: J7TS49
• Organism: Streptococcus salivarius strain ATCC 27945
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 341653..352327

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NX99_RS01130 (NX99_01120)	-	342765..343337 (-)	573	WP_084914458.1	ECF transporter S component	-
NX99_RS01135 (NX99_01125)	coaC	343366..343911 (-)	546	WP_037600829.1	phosphopantothenoylcysteine decarboxylase	-
NX99_RS01140 (NX99_01130)	-	343904..344587 (-)	684	WP_037600832.1	phosphopantothenate--cysteine ligase	-
NX99_RS01145 (NX99_01135)	-	344783..346453 (+)	1671	WP_037600835.1	formate--tetrahydrofolate ligase	-
NX99_RS01150 (NX99_01140)	ciaR	346653..347327 (+)	675	WP_002891134.1	response regulator transcription factor	Regulator
NX99_RS01155 (NX99_01145)	ciaH	347317..348732 (+)	1416	WP_073687949.1	sensor histidine kinase	Regulator
NX99_RS01160 (NX99_01150)	rpsT	348810..349046 (-)	237	WP_004182129.1	30S ribosomal protein S20	-
NX99_RS01165 (NX99_01155)	coaA	349116..350036 (-)	921	WP_064525024.1	type I pantothenate kinase	-
NX99_RS01170 (NX99_01160)	-	350149..350739 (+)	591	WP_084914459.1	class I SAM-dependent methyltransferase	-
NX99_RS01175 (NX99_01165)	-	350736..352013 (+)	1278	WP_084914461.1	pyrimidine-nucleoside phosphorylase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25362.02 Da
• Isoelectric Point: 4.2897

>NTDB_id=178195 NX99_RS01150 WP_002891134.1 346653..347327(+) (ciaR) [Streptococcus salivarius strain ATCC 27945]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=178195 NX99_RS01150 WP_002891134.1 346653..347327(+) (ciaR) [Streptococcus salivarius strain ATCC 27945]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
GATGCAAGTCTTTGATGGAGATGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACCTTATGT
TACCTGAAAAAGATGGTTTCACGGTTCTTAGAGAATTACGTGAAAAAGGTGTAACAACTCCTGTACTTATCATGACGGCT
AAGGAAAGTCTAGATGATAAGGGTCATGGCTTTGAACTGGGTGCAGACGACTATCTAACCAAACCTTTCTATTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTTTTGAAACGATCTGGTAAATTTGACCAAAACACACTTTCTTTTGGGGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGGGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAAAATGTCATCTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACGGT
ATCAGTTGTCGAGGTTTATGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGACTTTGCTGCCAATCTCCAAACCTTGA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: J7TS49

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae D39	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae R6	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae TIGR4	87.444	99.554	0.871
ciaR	Streptococcus mutans UA159	86.607	100	0.866
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.222	100	0.384
vicR	Streptococcus mutans UA159	35.983	100	0.384
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362