Detailed information NTG0173338

Bioinformatically predicted

Overview

• Name: clpP
• Type: Regulator
• Locus tag: A0O21_RS01715
• Genome accession: NZ_CP014699
• Coordinates: 369246..369836 (+)
• Length: 196 a.a.
• NCBI ID: WP_067060427.1
• Uniprot ID: A0A172Q5S8
• Organism: Streptococcus pantholopis strain TA 26
• Function: degradation of ComX; require for competence development (at the early growth phase); repress competence development (at the mid-logarithmic growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 364246..374836

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A0O21_RS01705 (A0O21_01710)	-	366149..368059 (+)	1911	WP_418346446.1	glycoside hydrolase family 68 protein	-
A0O21_RS01710 (A0O21_01715)	upp	368528..369157 (+)	630	WP_067060424.1	uracil phosphoribosyltransferase	-
A0O21_RS01715 (A0O21_01720)	clpP	369246..369836 (+)	591	WP_067060427.1	ATP-dependent Clp protease proteolytic subunit	Regulator
A0O21_RS01720 (A0O21_01725)	-	370151..370618 (+)	468	WP_067065019.1	YlbF family regulator	-
A0O21_RS01725 (A0O21_01730)	-	370599..370859 (+)	261	WP_067060429.1	DUF2129 domain-containing protein	-
A0O21_RS01730 (A0O21_01735)	-	370936..372105 (+)	1170	WP_067060431.1	ABC transporter substrate-binding protein	-
A0O21_RS01735 (A0O21_01740)	-	372363..373231 (+)	869	Protein_347	branched-chain amino acid ABC transporter permease	-
A0O21_RS01740 (A0O21_01745)	-	373236..374192 (+)	957	WP_067060433.1	branched-chain amino acid ABC transporter permease	-

Sequence

Protein

• Length: 196 a.a.
• Molecular weight: 21757.89 Da
• Isoelectric Point: 4.4735

>NTDB_id=173338 A0O21_RS01715 WP_067060427.1 369246..369836(+) (clpP) [Streptococcus pantholopis strain TA 26]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSIIAQLLFLDAQDNTKDIYLYVNTPGGSVTAGLAIVDTMN
FIKSDVQTIVMGMAASMGTIIASSGAKGKRFMLPNAEYLIHQPMGGTGSGTQQSDMAIVAEQLLKTRNKLEQILSENSGK
PIEQIHKDAERDYWMDAKETLEYGFIDEIMENNELK

Nucleotide

• Length: 591 bp

>NTDB_id=173338 A0O21_RS01715 WP_067060427.1 369246..369836(+) (clpP) [Streptococcus pantholopis strain TA 26]
ATGATTCCTGTAGTTATTGAACAAACAAGCCGCGGCGAACGTTCGTATGATATCTACTCTCGTCTTTTAAAAGACCGTAT
TATCATGCTGACAGGTCCGGTTGAAGATAATATGGCCAACTCAATTATTGCCCAGCTCCTTTTTTTGGATGCCCAGGATA
ATACTAAAGATATCTACCTTTATGTTAATACTCCGGGTGGTTCTGTGACAGCCGGCCTTGCGATTGTTGACACAATGAAC
TTTATCAAGTCCGATGTGCAAACTATTGTTATGGGGATGGCTGCTTCCATGGGAACCATCATTGCTTCAAGCGGTGCTAA
AGGAAAACGTTTCATGTTGCCTAATGCCGAATATCTTATCCACCAGCCGATGGGAGGAACAGGAAGCGGTACGCAGCAGT
CAGACATGGCAATTGTTGCCGAACAGTTGCTGAAAACCCGCAATAAGCTGGAGCAAATTTTATCAGAGAATTCCGGCAAA
CCGATCGAACAAATCCATAAAGATGCTGAACGCGATTACTGGATGGACGCTAAAGAAACGCTGGAATACGGCTTTATTGA
CGAAATTATGGAAAATAATGAACTGAAATAG

Domains

Predicted by InterproScan.

• Clp protease (CLP_protease) (11-192)

3D structure

• AlphaFold DB: A0A172Q5S8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpP	Streptococcus mutans UA159	93.878	100	0.939
clpP	Lactococcus lactis subsp. lactis strain DGCC12653	89.796	100	0.898
clpP	Streptococcus thermophilus LMG 18311	89.796	100	0.898
clpP	Streptococcus thermophilus LMD-9	89.796	100	0.898
clpP	Lactococcus lactis subsp. cremoris KW2	89.286	100	0.893
clpP	Streptococcus pyogenes JRS4	89.286	100	0.893
clpP	Streptococcus pyogenes MGAS315	89.286	100	0.893
clpP	Streptococcus pneumoniae Rx1	87.692	99.49	0.872
clpP	Streptococcus pneumoniae D39	87.692	99.49	0.872
clpP	Streptococcus pneumoniae R6	87.692	99.49	0.872
clpP	Streptococcus pneumoniae TIGR4	87.692	99.49	0.872
clpP	Bacillus subtilis subsp. subtilis str. 168	56.633	100	0.566
clpP	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	56.477	98.469	0.556