Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   AXE83_RS00215 Genome accession   NZ_CP014264
Coordinates   47133..48317 (+) Length   394 a.a.
NCBI ID   WP_060954978.1    Uniprot ID   A0A120KP88
Organism   Streptococcus sp. oral taxon 431 strain F0610 (5-114)     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 42133..53317
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AXE83_RS00185 (AXE83_00185) - 43014..43556 (+) 543 WP_060954975.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
  AXE83_RS00195 (AXE83_00195) comE 43962..44714 (-) 753 WP_049530388.1 competence system response regulator transcription factor ComE Regulator
  AXE83_RS00200 (AXE83_00200) comD 44711..46030 (-) 1320 WP_060954976.1 competence system sensor histidine kinase ComD Regulator
  AXE83_RS10325 comC 46053..46187 (-) 135 WP_080936286.1 competence-stimulating peptide ComC -
  AXE83_RS00210 (AXE83_00210) rlmH 46470..46949 (-) 480 WP_060954977.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  AXE83_RS00215 (AXE83_00215) htrA 47133..48317 (+) 1185 WP_060954978.1 trypsin-like peptidase domain-containing protein Regulator
  AXE83_RS00220 (AXE83_00220) spo0J 48374..49132 (+) 759 WP_049508355.1 ParB/RepB/Spo0J family partition protein Regulator
  AXE83_RS00225 (AXE83_00225) dnaA 49354..50709 (+) 1356 WP_049525669.1 chromosomal replication initiator protein DnaA -
  AXE83_RS00230 (AXE83_00230) dnaN 50867..52003 (+) 1137 WP_049508360.1 DNA polymerase III subunit beta -
  AXE83_RS00235 (AXE83_00235) - 52070..52264 (+) 195 WP_000285188.1 DUF951 family protein -

Sequence

Protein


Download         Length: 394 a.a.        Molecular weight: 41507.46 Da        Isoelectric Point: 5.4511

>NTDB_id=169971 AXE83_RS00215 WP_060954978.1 47133..48317(+) (htrA) [Streptococcus sp. oral taxon 431 strain F0610 (5-114)]
MKNLKTSSKKWGQLLVVILISFFSGILGTFTTLQLSQKQNSGTTTTTTVSKTAVKNENSTTQAVDKVKDAVVSVITYSSN
SQNSLLGSDETDTDTNAEQVYSEGSGVIYKKEGDTAYLVTNTHVINGAKKVDIRLADGTKVPGEIVGSDTYSDIAVVKIA
ADKVTTVAEFGDSSQLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTNAIQTDTAINPGNSGGPLI
NIQGQVIGITSSKIASNGGTSVEGLGFAIPANDVINIIKQLEKDGKVTRPALGIHMVNLSNLSTTDLQKLKLPGNVTSGV
AIRSVQKNMPANGHLQQYDVITKIDDKAISSTTELQSALYSHSIGDSMTVTYYRDGKEETTTIKLDKSTSDLDK

Nucleotide


Download         Length: 1185 bp        

>NTDB_id=169971 AXE83_RS00215 WP_060954978.1 47133..48317(+) (htrA) [Streptococcus sp. oral taxon 431 strain F0610 (5-114)]
ATGAAAAACTTAAAAACTAGTTCCAAAAAATGGGGACAACTTTTAGTAGTCATTCTCATTAGCTTTTTTAGTGGTATTTT
AGGTACTTTTACCACATTGCAGCTCAGTCAAAAACAAAATAGTGGTACGACAACTACAACGACTGTCAGCAAAACAGCTG
TAAAAAATGAAAACTCAACTACACAGGCAGTCGATAAAGTTAAAGATGCTGTTGTATCTGTCATTACTTACTCATCAAAT
TCTCAAAATAGTTTACTCGGATCTGATGAAACTGATACAGATACCAATGCTGAACAAGTATACAGCGAAGGTTCTGGGGT
CATTTATAAAAAGGAAGGGGATACTGCCTACCTTGTAACCAATACTCACGTTATTAATGGCGCTAAAAAAGTTGATATTC
GTTTAGCAGATGGCACAAAAGTCCCTGGTGAAATTGTGGGTTCTGATACTTATTCAGATATTGCCGTTGTAAAAATTGCT
GCAGATAAGGTCACAACAGTAGCCGAATTTGGTGATTCTAGTCAACTAACAGTTGGAGAAACAGCTATTGCAATCGGAAG
TCCTCTAGGTTCTGAATATGCCAATACTGTGACACAGGGGATTGTATCAAGTTTAAATAGAAATGTCTCTCTAAAATCTG
AAGACGGACAAGCTATCTCAACCAATGCTATCCAAACAGATACAGCTATTAACCCTGGGAACTCAGGTGGTCCTTTGATT
AATATCCAAGGTCAAGTTATCGGTATTACATCAAGTAAGATTGCCTCTAATGGTGGAACATCTGTCGAAGGTCTTGGTTT
TGCCATTCCTGCAAACGACGTAATCAATATTATTAAGCAGTTGGAAAAAGATGGAAAAGTAACTCGACCTGCTCTTGGAA
TCCACATGGTTAACTTATCAAATCTTAGTACAACTGATCTTCAAAAACTAAAACTTCCTGGAAATGTTACTTCTGGTGTA
GCTATTCGTTCTGTTCAAAAAAATATGCCTGCCAATGGACATCTGCAACAATATGACGTCATTACAAAAATAGATGATAA
AGCTATTTCTTCCACTACTGAATTGCAAAGTGCTCTATATAGTCATTCTATTGGAGACAGTATGACTGTTACTTACTACC
GTGATGGTAAGGAAGAAACAACAACTATTAAATTAGATAAAAGTACTAGTGATTTAGATAAGTAG

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(104-249)

PDZ domain (PDZ_2)

(290-385)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A120KP88

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

77.919

100

0.779
  htrA Streptococcus pneumoniae Rx1

77.665

100

0.777
  htrA Streptococcus pneumoniae D39

77.665

100

0.777
  htrA Streptococcus pneumoniae R6

77.665

100

0.777
  htrA Streptococcus pneumoniae TIGR4

77.665

100

0.777
  htrA Streptococcus gordonii str. Challis substr. CH1

68.17

100

0.69
  htrA Streptococcus mutans UA159

54.082

99.492

0.538

Multiple sequence alignment