Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD   Type   Regulator
Locus tag   AXE83_RS00200 Genome accession   NZ_CP014264
Coordinates   44711..46030 (-) Length   439 a.a.
NCBI ID   WP_060954976.1    Uniprot ID   A0A109W851
Organism   Streptococcus sp. oral taxon 431 strain F0610 (5-114)     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 39711..51030
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AXE83_RS00180 (AXE83_00180) - 40222..42885 (-) 2664 WP_060954974.1 YhgE/Pip domain-containing protein -
  AXE83_RS00185 (AXE83_00185) - 43014..43556 (+) 543 WP_060954975.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
  AXE83_RS00195 (AXE83_00195) comE 43962..44714 (-) 753 WP_049530388.1 competence system response regulator transcription factor ComE Regulator
  AXE83_RS00200 (AXE83_00200) comD 44711..46030 (-) 1320 WP_060954976.1 competence system sensor histidine kinase ComD Regulator
  AXE83_RS10325 comC 46053..46187 (-) 135 WP_080936286.1 competence-stimulating peptide ComC -
  AXE83_RS00210 (AXE83_00210) rlmH 46470..46949 (-) 480 WP_060954977.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  AXE83_RS00215 (AXE83_00215) htrA 47133..48317 (+) 1185 WP_060954978.1 trypsin-like peptidase domain-containing protein Regulator
  AXE83_RS00220 (AXE83_00220) spo0J 48374..49132 (+) 759 WP_049508355.1 ParB/RepB/Spo0J family partition protein Regulator
  AXE83_RS00225 (AXE83_00225) dnaA 49354..50709 (+) 1356 WP_049525669.1 chromosomal replication initiator protein DnaA -

Sequence

Protein


Download         Length: 439 a.a.        Molecular weight: 51150.94 Da        Isoelectric Point: 8.3052

>NTDB_id=169970 AXE83_RS00200 WP_060954976.1 44711..46030(-) (comD) [Streptococcus sp. oral taxon 431 strain F0610 (5-114)]
MNLFGLVIAIVYVFIISKIHEWVCKATRKDQYFFSLYIFLIPLVLEIILYFLKLDSFSLSKFLFPFLLFGYFVGFKKYEK
SKGIFISLLFSLLYNSTNNFLSVTLSSITGDEFALKYNNYFSLFILILTYLVIKVVVSYFHLEFKYFDKDYLYPFLKKVL
FAFIFLHVVSFTSDIVSTIRHLNGFGSILSSIVFVGLLLTFFSMNSHKVQIEKEIELEQKKFEQKHLQTYTDEIVALYNE
IRGFRHDYTGMLVSLRMAIESKDLQEIDRVYSEVLVKANQKLRSDKYTYFDLNNIEDSALRSLIAQSIVNAKTNNVEYTL
EVKDVITPLSMELLDLVRVMSVLLNNAVEGAVESYQKQLEVAIIKLDLETLVVIQNSCKKRKVKSEDLFELGFSTKGRHR
GLGLNNVKEILGKYDNVILETEIDNDVFKQVIRFKRELI

Nucleotide


Download         Length: 1320 bp        

>NTDB_id=169970 AXE83_RS00200 WP_060954976.1 44711..46030(-) (comD) [Streptococcus sp. oral taxon 431 strain F0610 (5-114)]
ATGAATTTATTCGGATTAGTAATTGCTATTGTTTATGTTTTTATTATTAGTAAAATTCATGAATGGGTTTGTAAAGCAAC
TAGAAAAGACCAATATTTTTTTAGTCTTTATATATTTCTAATACCATTAGTATTGGAAATAATTCTCTATTTCTTGAAAT
TAGATAGTTTTAGTTTGTCTAAATTTTTATTTCCTTTCCTCCTATTTGGTTACTTTGTTGGATTTAAGAAGTATGAGAAA
TCTAAGGGAATTTTTATCAGTCTATTATTTTCTCTTTTATATAATAGTACTAATAACTTTTTATCAGTAACCTTATCATC
TATTACAGGAGATGAGTTTGCATTGAAGTATAACAATTATTTTTCTCTATTTATCCTGATCTTAACTTATTTGGTTATTA
AAGTTGTTGTGTCTTATTTCCATCTCGAATTTAAATATTTTGATAAAGACTATCTATATCCTTTTCTGAAGAAAGTGCTC
TTTGCATTTATTTTTCTACACGTTGTCTCTTTCACTTCAGATATTGTGAGTACGATTCGTCACTTAAATGGTTTTGGAAG
TATTTTATCATCCATTGTTTTTGTTGGCCTACTTTTGACTTTTTTCTCCATGAATTCTCATAAAGTTCAGATAGAAAAAG
AAATTGAATTGGAACAAAAGAAGTTTGAGCAAAAACACTTACAAACTTACACGGATGAGATTGTTGCCTTATATAATGAA
ATTCGTGGTTTTCGCCATGATTATACAGGCATGCTTGTCAGCTTAAGAATGGCGATCGAAAGTAAAGATTTACAAGAAAT
TGACAGAGTTTACAGTGAAGTTCTTGTAAAGGCGAATCAAAAATTACGTTCAGATAAGTATACTTATTTCGATTTGAATA
ATATTGAGGATTCAGCTCTTCGTAGTTTGATTGCTCAATCTATTGTCAATGCGAAAACTAATAATGTAGAGTACACACTA
GAGGTAAAAGATGTCATTACTCCTTTGTCCATGGAATTGTTAGATTTGGTGCGCGTGATGAGTGTTCTGCTCAATAATGC
CGTTGAGGGAGCAGTTGAAAGCTATCAGAAACAACTAGAGGTAGCTATTATCAAGTTGGATCTTGAAACTCTAGTTGTCA
TCCAAAACTCTTGTAAAAAAAGAAAGGTAAAATCCGAAGATTTATTTGAATTAGGATTTTCAACTAAAGGAAGACATAGA
GGACTTGGACTTAATAATGTTAAAGAAATTTTAGGAAAATATGACAATGTTATTTTAGAAACAGAAATTGATAATGATGT
ATTTAAACAAGTAATTAGATTTAAGAGGGAACTGATATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(331-432)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A109W851

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD Streptococcus mitis NCTC 12261

67.654

100

0.677
  comD Streptococcus mitis SK321

67.426

100

0.674
  comD/comD2 Streptococcus pneumoniae TIGR4

66.515

100

0.665
  comD/comD1 Streptococcus pneumoniae R6

66.287

100

0.663
  comD/comD1 Streptococcus pneumoniae Rx1

66.287

100

0.663
  comD/comD1 Streptococcus pneumoniae D39

66.287

100

0.663
  comD/comD2 Streptococcus gordonii strain NCTC7865

48.421

86.56

0.419
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

48.677

86.105

0.419

Multiple sequence alignment