Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   ATM98_RS06920 Genome accession   NZ_CP013651
Coordinates   1450453..1451631 (+) Length   392 a.a.
NCBI ID   WP_061564541.1    Uniprot ID   -
Organism   Streptococcus sp. A12     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1445453..1456631
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ATM98_RS06900 (ATM98_06900) comE/comE2 1447206..1447958 (-) 753 WP_048690420.1 response regulator transcription factor Regulator
  ATM98_RS09765 - 1447959..1449284 (-) 1326 WP_065426966.1 GHKL domain-containing protein -
  ATM98_RS09280 - 1449284..1449415 (-) 132 WP_082161867.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  ATM98_RS06915 (ATM98_06915) rlmH 1449772..1450251 (-) 480 WP_048690423.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  ATM98_RS06920 (ATM98_06920) htrA 1450453..1451631 (+) 1179 WP_061564541.1 S1C family serine protease Regulator
  ATM98_RS06925 (ATM98_06925) spo0J 1451697..1452458 (+) 762 WP_048690428.1 ParB/RepB/Spo0J family partition protein Regulator
  ATM98_RS06930 (ATM98_06930) dnaA 1452709..1454079 (+) 1371 WP_048690429.1 chromosomal replication initiator protein DnaA -
  ATM98_RS06935 (ATM98_06935) dnaN 1454240..1455376 (+) 1137 WP_006595327.1 DNA polymerase III subunit beta -
  ATM98_RS06940 (ATM98_06940) - 1455440..1455631 (+) 192 WP_061564542.1 DUF951 family protein -
  ATM98_RS06945 (ATM98_06945) - 1455667..1456161 (-) 495 WP_061564543.1 DUF1307 domain-containing protein -

Sequence

Protein


Download         Length: 392 a.a.        Molecular weight: 41429.91 Da        Isoelectric Point: 5.8606

>NTDB_id=163416 ATM98_RS06920 WP_061564541.1 1450453..1451631(+) (htrA) [Streptococcus sp. A12]
MKQPSNFLKKILQLLLVLVIGFTGGILGTLTSFQFTKGNSTNPSQEIKSTKVNRAYKNTTSTSEAVDKVKNAVVSVITYA
ETSEKGFINGETDSDPEVASEGSGVIYKKDGKDAYLVTNAHVLMGATKADILFADGNKVSGEVVGSDTFSDIAVVKISSD
NVTTVAEFGDSSKLTVGETAIAIGSPLGTKFANSVTQGIVSSLGRTVKLKSEDGQNVSTKALQTDAAINPGNSGGPLINI
QGQVIGITSSKISSNGQTAVEGMGFAIPVNDVQNIIEHLEKDGKVIRPALGITMMDLANLSSSDLSQLDIPSKLKGGVLV
RSVENDMPASKYLRRLDIITKIDDTTIESTADLQSALYSHQIGDKIKVIFYRDGKQKTATIELTKSTENLGN

Nucleotide


Download         Length: 1179 bp        

>NTDB_id=163416 ATM98_RS06920 WP_061564541.1 1450453..1451631(+) (htrA) [Streptococcus sp. A12]
ATGAAACAACCATCAAATTTTCTAAAAAAAATTTTGCAACTTTTACTTGTTCTTGTCATTGGGTTTACTGGAGGAATCTT
AGGGACCTTGACCTCTTTCCAGTTTACCAAGGGGAATTCTACAAATCCTAGCCAAGAAATAAAATCTACCAAAGTTAATC
GTGCTTATAAGAATACAACATCAACTAGTGAAGCTGTTGATAAGGTTAAAAATGCTGTTGTTTCTGTTATTACCTATGCT
GAAACCTCTGAAAAAGGCTTCATCAATGGAGAAACAGATTCTGATCCAGAAGTAGCTAGTGAAGGTTCAGGTGTTATCTA
TAAAAAAGACGGTAAAGATGCTTATTTAGTAACAAATGCCCACGTATTAATGGGAGCAACAAAAGCCGATATTCTCTTTG
CAGATGGAAATAAAGTTTCTGGAGAAGTTGTTGGTTCTGATACTTTCTCAGATATTGCGGTTGTTAAAATCAGTTCAGAT
AATGTTACGACCGTGGCTGAATTTGGGGATTCATCTAAGTTGACTGTTGGAGAGACCGCAATCGCTATTGGTAGTCCTTT
AGGAACAAAATTTGCCAATTCCGTTACCCAAGGGATTGTCTCTAGTCTCGGACGTACTGTGAAGCTCAAATCAGAAGACG
GCCAAAATGTATCTACAAAAGCGTTACAAACGGACGCTGCAATCAACCCAGGGAATTCTGGTGGTCCTCTTATCAATATT
CAGGGACAAGTCATCGGAATCACCTCAAGTAAAATCTCTTCAAATGGCCAAACTGCGGTTGAGGGAATGGGATTTGCAAT
TCCTGTAAATGATGTACAAAATATTATTGAACATTTAGAAAAAGATGGTAAAGTCATTCGTCCAGCTCTTGGAATTACCA
TGATGGACCTGGCTAACCTATCCTCTTCTGATCTTAGCCAATTAGACATTCCAAGCAAACTCAAAGGTGGGGTTCTTGTC
CGCTCAGTTGAAAATGATATGCCGGCATCCAAATATTTGCGTCGATTAGATATCATTACAAAAATCGATGACACAACCAT
TGAATCAACTGCAGATTTACAATCTGCCCTCTATTCTCATCAAATTGGTGATAAAATTAAAGTCATTTTCTATAGAGATG
GTAAGCAAAAAACAGCTACCATTGAGCTGACAAAATCTACAGAAAATCTTGGAAATTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(288-383)

Trypsin-like peptidase domain (Trypsin_2)

(102-247)

Peptidase family M50 (Peptidase_M50)

(233-388)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

63.265

100

0.633
  htrA Streptococcus pneumoniae Rx1

63.265

100

0.633
  htrA Streptococcus pneumoniae D39

63.265

100

0.633
  htrA Streptococcus pneumoniae R6

63.265

100

0.633
  htrA Streptococcus pneumoniae TIGR4

63.265

100

0.633
  htrA Streptococcus gordonii str. Challis substr. CH1

62.437

100

0.628
  htrA Streptococcus mutans UA159

52.778

100

0.533

Multiple sequence alignment