Detailed information NTG0160711

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: HSISS4_RS05670
• Genome accession: NZ_CP013216
• Coordinates: 1187522..1188196 (-)
• Length: 224 a.a.
• NCBI ID: WP_021144033.1
• Uniprot ID: -
• Organism: Streptococcus salivarius strain HSISS4
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1182522..1193196

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HSISS4_RS05645 (HSISS4_01092)	-	1182836..1184113 (-)	1278	WP_059749185.1	pyrimidine-nucleoside phosphorylase	-
HSISS4_RS05650 (HSISS4_01093)	-	1184110..1184700 (-)	591	WP_014633038.1	class I SAM-dependent methyltransferase	-
HSISS4_RS05655 (HSISS4_01094)	coaA	1184813..1185733 (+)	921	WP_059749264.1	type I pantothenate kinase	-
HSISS4_RS05660 (HSISS4_01095)	rpsT	1185803..1186039 (+)	237	WP_004182129.1	30S ribosomal protein S20	-
HSISS4_RS05665 (HSISS4_01096)	ciaH	1186117..1187532 (-)	1416	WP_037620265.1	sensor histidine kinase	Regulator
HSISS4_RS05670 (HSISS4_01097)	ciaR	1187522..1188196 (-)	675	WP_021144033.1	response regulator transcription factor	Regulator
HSISS4_RS05675 (HSISS4_01098)	-	1188394..1190064 (-)	1671	WP_021144032.1	formate--tetrahydrofolate ligase	-
HSISS4_RS05680 (HSISS4_01099)	-	1190258..1190941 (+)	684	WP_059749187.1	phosphopantothenate--cysteine ligase	-
HSISS4_RS05685 (HSISS4_01100)	coaC	1190934..1191479 (+)	546	WP_021144029.1	phosphopantothenoylcysteine decarboxylase	-
HSISS4_RS05690 (HSISS4_01101)	-	1191508..1192080 (+)	573	WP_021144028.1	ECF transporter S component	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25374.07 Da
• Isoelectric Point: 4.2897

>NTDB_id=160711 HSISS4_RS05670 WP_021144033.1 1187522..1188196(-) (ciaR) [Streptococcus salivarius strain HSISS4]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSIFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=160711 HSISS4_RS05670 WP_021144033.1 1187522..1188196(-) (ciaR) [Streptococcus salivarius strain HSISS4]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
GATGCAAGTCTTTGATGGAGATGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACCTTATGT
TACCTGAAAAAGATGGTTTCACGGTTCTTAGAGAATTACGTGAAAAAGGTGTAACAACTCCTGTACTTATCATGACGGCT
AAGGAAAGTCTAGATGATAAGGGTCATGGCTTTGAACTGGGTGCAGACGACTATCTAACCAAACCTTTCTATTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTTTTGAAACGATCTGGTAAATTTGACCAAAACACACTTTCTTTTGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAATCTTTGTGGGGGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAAAACGTGATTTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACAGT
ATCAGTTGTTGAGGTTTATGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGACTTTGCTGCCAATCTCCAAACCTTGA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

• Response regulator receiver domain (Response_reg) (4-112)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae D39	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae R6	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae TIGR4	87.444	99.554	0.871
ciaR	Streptococcus mutans UA159	86.161	100	0.862
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.222	100	0.384
vicR	Streptococcus mutans UA159	35.983	100	0.384
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362