Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   RN86_RS03030 Genome accession   NZ_CP012648
Coordinates   647856..649049 (-) Length   397 a.a.
NCBI ID   WP_045504979.1    Uniprot ID   A0AAW3H246
Organism   Streptococcus gordonii strain KCOM 1506 (= ChDC B679)     
Function   repress competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 647856..673926 647856..649049 within 0


Gene organization within MGE regions


Location: 647856..673926
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RN86_RS03030 (RN86_03025) htrA 647856..649049 (-) 1194 WP_045504979.1 S1C family serine protease Regulator
  RN86_RS03035 (RN86_03030) rlmH 649243..649722 (+) 480 WP_008808034.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  RN86_RS11220 comC/comC1 650008..650172 (+) 165 WP_080998577.1 bacteriocin Regulator
  RN86_RS03050 (RN86_03045) comD/comD2 650185..651546 (+) 1362 WP_052721528.1 competence system sensor histidine kinase ComD Regulator
  RN86_RS03055 (RN86_03050) comE/comE2 651543..652310 (+) 768 WP_008808031.1 competence system response regulator transcription factor ComE Regulator
  RN86_RS03070 (RN86_03065) ychF 652632..653747 (+) 1116 WP_008808030.1 redox-regulated ATPase YchF -
  RN86_RS03075 (RN86_03070) pth 653821..654390 (+) 570 WP_046164770.1 aminoacyl-tRNA hydrolase -
  RN86_RS03080 (RN86_03075) mfd 654383..657886 (+) 3504 WP_155465098.1 transcription-repair coupling factor -
  RN86_RS03085 (RN86_03080) - 657952..658218 (+) 267 WP_012131074.1 RNA-binding S4 domain-containing protein -
  RN86_RS03090 (RN86_03085) - 658211..658579 (+) 369 WP_008808026.1 septum formation initiator family protein -
  RN86_RS11595 (RN86_03090) - 658582..658701 (+) 120 WP_037622626.1 SP_0009 family protein -
  RN86_RS03100 (RN86_03095) - 658701..659981 (+) 1281 WP_046164769.1 serine hydrolase -
  RN86_RS03105 (RN86_03100) tilS 659978..661255 (+) 1278 WP_053794274.1 tRNA lysidine(34) synthetase TilS -
  RN86_RS03110 (RN86_03105) hpt 661260..661802 (+) 543 WP_046164767.1 hypoxanthine phosphoribosyltransferase -
  RN86_RS03115 (RN86_03110) ftsH 661821..663803 (+) 1983 WP_053794275.1 ATP-dependent zinc metalloprotease FtsH -
  RN86_RS03130 (RN86_03125) comR/comR2 664332..664814 (+) 483 WP_045772576.1 sigma-70 family RNA polymerase sigma factor Regulator
  RN86_RS03290 (RN86_03285) mreC 672609..673424 (+) 816 WP_053794276.1 rod shape-determining protein MreC -
  RN86_RS03295 (RN86_03290) mreD 673426..673926 (+) 501 WP_046164571.1 rod shape-determining protein MreD -

Sequence

Protein


Download         Length: 397 a.a.        Molecular weight: 42237.96 Da        Isoelectric Point: 5.4938

>NTDB_id=156057 RN86_RS03030 WP_045504979.1 647856..649049(-) (htrA) [Streptococcus gordonii strain KCOM 1506 (= ChDC B679)]
MKNSSNFFKKTLQVFIVLLVGFIGGVAGTWGFSYFSTPHSAVNNNQKTATTITTSYKNSNSTTKAVDKVKDAVVSVITYS
ESNSDTIFDNNNSGNENDQVASEGSGVIYRKDKDYAYLVTNTHVINGAKKVDIRLADGNKVPGEIVGTDTYSDISVVRIP
ADKVKNVAEFGDSSKLTVGETAIAIGSPLGSDYANTVTQGIVSSLSRNVSSRSEDGQTIATQAIQTDAAINPGNSGGPLV
NIQGQVIGITSSKIANTNNGSTSVEGMGFAIPSNDVVNIIEQLEKNGKVIRPALGIQMVNLSSLSSSSSDRLKLPENVKN
GVVVRSTQTGMPADGKLQKYDVITKIDDTEISSASDIQSALYKHSINEEIKVTYYRDGKEQTTTIKLTKSTDDLSSE

Nucleotide


Download         Length: 1194 bp        

>NTDB_id=156057 RN86_RS03030 WP_045504979.1 647856..649049(-) (htrA) [Streptococcus gordonii strain KCOM 1506 (= ChDC B679)]
ATGAAAAACTCTTCAAATTTCTTCAAAAAAACATTGCAAGTTTTCATTGTTTTGTTAGTTGGTTTTATAGGTGGTGTTGC
TGGAACATGGGGATTTTCTTATTTTTCAACACCTCATTCAGCCGTAAATAATAATCAGAAAACAGCAACTACAATAACAA
CATCCTATAAAAATAGTAATTCTACAACAAAGGCTGTTGATAAAGTAAAAGATGCTGTTGTCTCTGTCATTACATATTCT
GAATCTAATTCGGATACTATTTTTGACAACAATAATTCAGGAAATGAAAATGATCAGGTAGCTAGCGAAGGATCTGGTGT
TATCTATAGAAAAGATAAAGACTATGCTTACTTAGTTACCAATACACACGTTATCAATGGAGCAAAAAAAGTTGATATCC
GTCTTGCTGATGGGAATAAGGTTCCTGGTGAAATAGTCGGGACTGATACATATTCTGATATTTCTGTAGTCAGAATTCCT
GCCGATAAGGTTAAAAATGTAGCAGAATTTGGGGATTCTAGTAAATTAACTGTTGGGGAAACTGCCATTGCAATCGGAAG
TCCTCTTGGATCTGATTATGCTAATACAGTAACTCAGGGAATTGTTTCTAGTCTAAGCCGTAATGTTTCTTCACGATCAG
AAGATGGTCAAACAATTGCTACCCAAGCTATTCAAACTGATGCAGCAATTAATCCAGGTAACTCTGGTGGTCCTCTTGTA
AACATTCAAGGTCAAGTTATTGGTATTACCTCTAGTAAAATTGCTAACACCAATAATGGTAGTACTTCTGTTGAGGGAAT
GGGATTTGCAATCCCATCCAATGATGTTGTAAATATCATTGAACAATTAGAAAAGAATGGTAAAGTCATTCGACCAGCAT
TAGGAATTCAAATGGTCAACTTAAGTAGTTTGTCTTCTTCAAGCTCTGATCGATTAAAACTTCCAGAAAATGTTAAGAAT
GGTGTCGTTGTTCGTTCCACACAAACTGGAATGCCTGCTGATGGTAAGTTACAAAAATATGATGTGATTACAAAAATTGA
CGATACAGAAATATCATCTGCTAGCGATATCCAATCAGCTCTTTATAAACATTCAATTAATGAAGAAATTAAAGTTACTT
ATTATCGTGATGGAAAAGAGCAAACAACAACTATTAAACTAACTAAATCAACTGATGATTTAAGTTCTGAATAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(236-391)

PDZ domain (PDZ_2)

(292-387)

Trypsin-like peptidase domain (Trypsin_2)

(104-249)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

98.489

100

0.985
  htrA Streptococcus pneumoniae Rx1

66.414

99.748

0.662
  htrA Streptococcus pneumoniae D39

66.414

99.748

0.662
  htrA Streptococcus pneumoniae R6

66.414

99.748

0.662
  htrA Streptococcus pneumoniae TIGR4

66.414

99.748

0.662
  htrA Streptococcus mitis NCTC 12261

66.08

100

0.662
  htrA Streptococcus mutans UA159

56.14

100

0.564

Multiple sequence alignment