Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   AXF35_RS06585 Genome accession   NZ_CP014255
Coordinates   1413092..1413769 (-) Length   225 a.a.
NCBI ID   WP_011213604.1    Uniprot ID   -
Organism   Legionella pneumophila subsp. pascullei strain F-4185     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1408092..1418769
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AXF35_RS06565 (AXF35_10260) ruvA 1408548..1409147 (+) 600 WP_027221486.1 Holliday junction branch migration protein RuvA Machinery gene
  AXF35_RS06570 (AXF35_10255) - 1409208..1409513 (+) 306 WP_231955182.1 hypothetical protein -
  AXF35_RS06575 (AXF35_10250) lem8 1409601..1411160 (-) 1560 WP_027221487.1 Dot/Icm T4SS effector Lem8 -
  AXF35_RS06580 (AXF35_10245) - 1411680..1413095 (-) 1416 WP_027221488.1 ATP-binding protein -
  AXF35_RS06585 (AXF35_10240) ciaR 1413092..1413769 (-) 678 WP_011213604.1 response regulator Regulator
  AXF35_RS06590 (AXF35_10235) - 1413830..1414375 (-) 546 WP_027221489.1 septation protein A -
  AXF35_RS06595 (AXF35_10230) - 1414619..1416058 (-) 1440 WP_027221490.1 lytic transglycosylase -
  AXF35_RS06600 (AXF35_10225) gloB 1416173..1416937 (-) 765 WP_027221491.1 hydroxyacylglutathione hydrolase -
  AXF35_RS06605 (AXF35_10220) - 1416941..1417789 (-) 849 WP_027221492.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
  AXF35_RS06610 (AXF35_10215) - 1418076..1418285 (+) 210 WP_011213609.1 hypothetical protein -

Sequence

Protein


Download         Length: 225 a.a.        Molecular weight: 25151.74 Da        Isoelectric Point: 4.9981

>NTDB_id=144871 AXF35_RS06585 WP_011213604.1 1413092..1413769(-) (ciaR) [Legionella pneumophila subsp. pascullei strain F-4185]
MRLLLVEDDELLGDAVKAGLTQFGYVVDWLKDGEAARAALKSESFELIILDLGLPKLSGLSLLQNIRHDGNSTPVIILTA
RESIEDRVKGLDSGADDYLIKPFDLNELSARIRALVRRSQGRADSVLQYKNITLDPAAHSVFVDDVLVNVPRREFALLQK
LLENSGQVLSREQLMQSIYGWEEDVDSNALEVHIHNLRKKLNANFIRTIRGVGYMAEKNDSVLLS

Nucleotide


Download         Length: 678 bp        

>NTDB_id=144871 AXF35_RS06585 WP_011213604.1 1413092..1413769(-) (ciaR) [Legionella pneumophila subsp. pascullei strain F-4185]
ATGAGATTATTACTTGTTGAAGACGATGAACTGCTTGGTGATGCAGTAAAAGCCGGACTGACACAATTTGGGTATGTTGT
TGACTGGCTAAAAGATGGCGAAGCTGCGCGAGCGGCTCTCAAATCAGAGTCTTTTGAATTAATTATTCTTGACTTGGGAT
TACCTAAATTATCCGGTTTATCATTATTACAAAACATCAGACATGATGGAAATTCCACGCCTGTCATTATTCTTACAGCT
CGGGAATCAATAGAAGATCGAGTAAAAGGTTTAGATAGTGGCGCTGACGATTATCTTATTAAACCTTTTGATTTAAACGA
ATTAAGTGCAAGGATTAGAGCCTTGGTAAGGCGCTCTCAGGGCAGAGCTGATTCAGTATTGCAATACAAAAATATTACCC
TTGATCCAGCCGCTCATTCTGTATTCGTGGATGATGTTCTCGTCAACGTTCCAAGAAGAGAATTTGCTCTATTGCAGAAA
TTACTTGAAAACAGTGGTCAAGTTTTATCTCGAGAACAATTAATGCAGAGTATTTATGGCTGGGAAGAAGACGTGGACAG
CAATGCTCTTGAAGTTCATATCCATAATTTACGTAAAAAACTTAATGCAAACTTTATCCGCACTATTCGTGGTGTGGGAT
ATATGGCTGAAAAAAATGACAGTGTACTTCTATCGTGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(148-215)

Response regulator receiver domain (Response_reg)

(4-113)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.356

97.333

0.373
  ciaR Streptococcus pneumoniae D39

38.356

97.333

0.373
  ciaR Streptococcus pneumoniae R6

38.356

97.333

0.373
  ciaR Streptococcus pneumoniae TIGR4

38.356

97.333

0.373
  ciaR Streptococcus mutans UA159

37.9

97.333

0.369
  micA Streptococcus pneumoniae Cp1015

35.345

100

0.364

Multiple sequence alignment