Detailed information    

insolico Bioinformatically predicted

Overview

Name   prx   Type   Regulator
Locus tag   SD89_RS06195 Genome accession   NZ_CP010449
Coordinates   1263411..1263593 (-) Length   60 a.a.
NCBI ID   WP_053308468.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NGAS322     
Function   Inhibit ComR activation (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1263411..1298561 1263411..1263593 within 0


Gene organization within MGE regions


Location: 1263411..1298561
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SD89_RS06195 (SD89_06210) prx 1263411..1263593 (-) 183 WP_053308468.1 Paratox Regulator
  SD89_RS06200 (SD89_06215) spel 1263708..1264496 (-) 789 WP_053308469.1 streptococcal pyrogenic exotoxin SpeL -
  SD89_RS06205 (SD89_06220) spem 1264778..1265491 (-) 714 WP_011017838.1 streptococcal pyrogenic exotoxin SpeM -
  SD89_RS06210 (SD89_06225) - 1266357..1266998 (-) 642 Protein_1187 CHAP domain-containing protein -
  SD89_RS06215 (SD89_06230) - 1267111..1267803 (-) 693 WP_002994484.1 AP2 domain-containing protein -
  SD89_RS06220 (SD89_06235) - 1268039..1268593 (-) 555 Protein_1189 glycoside hydrolase family 73 protein -
  SD89_RS06225 (SD89_06245) - 1268704..1268889 (-) 186 WP_011184796.1 holin -
  SD89_RS06230 (SD89_06250) - 1268886..1269182 (-) 297 WP_053308471.1 hypothetical protein -
  SD89_RS06235 (SD89_06255) - 1269179..1269820 (-) 642 WP_053308472.1 hypothetical protein -
  SD89_RS06240 (SD89_06260) - 1269823..1270254 (-) 432 WP_053308473.1 DUF1617 family protein -
  SD89_RS06245 (SD89_06265) - 1270263..1272044 (-) 1782 WP_053308474.1 gp58-like family protein -
  SD89_RS06250 (SD89_06270) - 1272059..1273168 (-) 1110 WP_053308475.1 hyaluronoglucosaminidase -
  SD89_RS06255 (SD89_06275) - 1273168..1275126 (-) 1959 WP_053308476.1 phage tail spike protein -
  SD89_RS06260 (SD89_06280) - 1275123..1275818 (-) 696 WP_010922452.1 hypothetical protein -
  SD89_RS06265 (SD89_06285) - 1275815..1278172 (-) 2358 WP_053308477.1 hypothetical protein -
  SD89_RS06270 (SD89_06290) - 1278172..1278543 (-) 372 WP_011054678.1 DUF5361 domain-containing protein -
  SD89_RS06275 (SD89_06295) - 1278558..1278821 (-) 264 WP_010922455.1 hypothetical protein -
  SD89_RS06280 (SD89_06300) - 1278832..1279422 (-) 591 WP_053308478.1 hypothetical protein -
  SD89_RS06285 (SD89_06305) - 1279438..1279773 (-) 336 WP_000573598.1 hypothetical protein -
  SD89_RS06290 (SD89_06310) - 1279774..1280010 (-) 237 WP_053308479.1 hypothetical protein -
  SD89_RS06295 (SD89_06315) - 1280003..1280341 (-) 339 WP_011054681.1 hypothetical protein -
  SD89_RS06300 (SD89_06320) - 1280301..1280723 (-) 423 WP_053308480.1 phage Gp19/Gp15/Gp42 family protein -
  SD89_RS10550 - 1280744..1280872 (-) 129 WP_258296905.1 hypothetical protein -
  SD89_RS06305 (SD89_06325) - 1280874..1281767 (-) 894 WP_053308481.1 phage major capsid protein -
  SD89_RS06310 (SD89_06330) - 1281771..1282235 (-) 465 WP_053308482.1 DUF4355 domain-containing protein -
  SD89_RS06315 (SD89_06335) - 1282316..1283731 (-) 1416 WP_011285619.1 terminase -
  SD89_RS06320 (SD89_06340) - 1283813..1284049 (-) 237 WP_011888764.1 hypothetical protein -
  SD89_RS06325 (SD89_06345) - 1284051..1284317 (-) 267 WP_002986828.1 hypothetical protein -
  SD89_RS06330 (SD89_06350) - 1284310..1284489 (-) 180 WP_032461150.1 hypothetical protein -
  SD89_RS06335 (SD89_06355) - 1284539..1284763 (-) 225 WP_002994100.1 hypothetical protein -
  SD89_RS06340 (SD89_06360) - 1284769..1286262 (-) 1494 WP_011017978.1 hypothetical protein -
  SD89_RS06345 (SD89_06365) - 1286255..1287523 (-) 1269 WP_053308483.1 phage portal protein -
  SD89_RS06350 (SD89_06370) - 1287520..1287876 (-) 357 WP_002994106.1 hypothetical protein -
  SD89_RS06355 (SD89_06375) - 1288025..1288369 (-) 345 WP_053308484.1 HNH endonuclease signature motif containing protein -
  SD89_RS06360 (SD89_06380) - 1288477..1288896 (-) 420 WP_003047501.1 DUF1492 domain-containing protein -
  SD89_RS06365 (SD89_06385) - 1288972..1289223 (-) 252 WP_053308485.1 hypothetical protein -
  SD89_RS06370 (SD89_06390) - 1289220..1289438 (-) 219 Protein_1220 DUF1642 domain-containing protein -
  SD89_RS10445 (SD89_06395) - 1289505..1289690 (-) 186 WP_011017985.1 hypothetical protein -
  SD89_RS06380 (SD89_06400) - 1289677..1290189 (-) 513 WP_053308486.1 hypothetical protein -
  SD89_RS06385 (SD89_06405) - 1290186..1290527 (-) 342 WP_053308487.1 hypothetical protein -
  SD89_RS06390 (SD89_06410) - 1290881..1291678 (-) 798 WP_053308488.1 PD-(D/E)XK nuclease-like domain-containing protein -
  SD89_RS06395 (SD89_06415) - 1291675..1292604 (-) 930 WP_053308489.1 recombinase RecT -
  SD89_RS06400 (SD89_06420) - 1292607..1292936 (-) 330 WP_032463369.1 hypothetical protein -
  SD89_RS06405 (SD89_06425) - 1292992..1293198 (-) 207 WP_011017565.1 hypothetical protein -
  SD89_RS10155 - 1293207..1293347 (-) 141 WP_011017992.1 hypothetical protein -
  SD89_RS06410 (SD89_06430) - 1293344..1293577 (-) 234 WP_002985387.1 hypothetical protein -
  SD89_RS06415 (SD89_06435) - 1293558..1293944 (-) 387 WP_023079927.1 DnaD domain-containing protein -
  SD89_RS10450 (SD89_06440) - 1294100..1294369 (-) 270 WP_053308490.1 replication protein -
  SD89_RS06425 (SD89_06445) - 1294463..1294648 (-) 186 WP_023079923.1 hypothetical protein -
  SD89_RS06430 (SD89_06450) - 1294650..1294961 (-) 312 WP_010922478.1 excisionase -
  SD89_RS06435 (SD89_06455) - 1295231..1295443 (-) 213 WP_010922479.1 helix-turn-helix domain-containing protein -
  SD89_RS06440 (SD89_06460) - 1295645..1296400 (+) 756 WP_010922480.1 helix-turn-helix domain-containing protein -
  SD89_RS06445 (SD89_06465) - 1296412..1296930 (+) 519 WP_010922481.1 HIRAN domain-containing protein -
  SD89_RS06450 (SD89_06470) - 1297054..1298196 (+) 1143 WP_053308491.1 tyrosine-type recombinase/integrase -
  SD89_RS06455 (SD89_06475) - 1298286..1298561 (-) 276 WP_002983920.1 HU family DNA-binding protein -

Sequence

Protein


Download         Length: 60 a.a.        Molecular weight: 7066.02 Da        Isoelectric Point: 4.0338

>NTDB_id=137340 SD89_RS06195 WP_053308468.1 1263411..1263593(-) (prx) [Streptococcus pyogenes strain NGAS322]
MLTYDEFKQAIDDGYIVGDTVMIVRKNGQIFDYVLPNEKIRDWEVVTDEKVEEVLVELSR

Nucleotide


Download         Length: 183 bp        

>NTDB_id=137340 SD89_RS06195 WP_053308468.1 1263411..1263593(-) (prx) [Streptococcus pyogenes strain NGAS322]
ATGCTAACATACGACGAATTTAAGCAAGCTATTGATGACGGATATATCGTAGGAGACACAGTTATGATCGTGCGCAAGAA
CGGACAGATTTTTGATTATGTGTTGCCGAATGAGAAGATAAGAGATTGGGAGGTTGTGACAGACGAAAAAGTGGAAGAGG
TGCTGGTGGAGCTTTCGAGATAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  prx Streptococcus pyogenes MGAS315

88.333

100

0.883
  prx Streptococcus pyogenes MGAS8232

83.333

100

0.833
  prx Streptococcus pyogenes MGAS315

80

100

0.8
  prx Streptococcus pyogenes MGAS315

70

100

0.7
  prx Streptococcus pyogenes MGAS315

90.476

70

0.633
  prx Streptococcus pyogenes MGAS315

90.244

68.333

0.617
  prx Streptococcus pyogenes MGAS315

78.571

70

0.55

Multiple sequence alignment