Detailed information NTG0125701

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: ID09_RS05760
• Genome accession: NZ_CP008921
• Coordinates: 1189941..1190612 (-)
• Length: 223 a.a.
• NCBI ID: WP_009909965.1
• Uniprot ID: A0A075SH40
• Organism: Streptococcus suis 6407
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1184941..1195612

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ID09_RS05740 (ID09_05905)	coaA	1185527..1186447 (+)	921	WP_024381359.1	type I pantothenate kinase	-
ID09_RS05745 (ID09_05910)	rpsT	1186506..1186754 (+)	249	WP_012027069.1	30S ribosomal protein S20	-
ID09_RS05750 (ID09_05920)	-	1187016..1188245 (-)	1230	WP_024381360.1	transglutaminase domain-containing protein	-
ID09_RS05755 (ID09_05925)	ciaH	1188569..1189948 (-)	1380	WP_024381361.1	sensor histidine kinase	Regulator
ID09_RS05760 (ID09_05930)	ciaR	1189941..1190612 (-)	672	WP_009909965.1	response regulator transcription factor	Regulator
ID09_RS12400	-	1190806..1190961 (-)	156	WP_228380904.1	hypothetical protein	-
ID09_RS12550	-	1191019..1191153 (-)	135	WP_255304292.1	hypothetical protein	-
ID09_RS05770 (ID09_05940)	phoU	1191319..1191975 (-)	657	WP_024390542.1	phosphate signaling complex protein PhoU	-
ID09_RS05775 (ID09_05945)	pstB	1192004..1192762 (-)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
ID09_RS05780 (ID09_05950)	pstB	1192774..1193577 (-)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
ID09_RS05785 (ID09_05955)	pstA	1193602..1194489 (-)	888	WP_024381362.1	phosphate ABC transporter permease PstA	-
ID09_RS05790 (ID09_05960)	pstC	1194479..1195396 (-)	918	WP_024381363.1	phosphate ABC transporter permease subunit PstC	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25290.00 Da
• Isoelectric Point: 4.2183

>NTDB_id=125701 ID09_RS05760 WP_009909965.1 1189941..1190612(-) (ciaR) [Streptococcus suis 6407]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTFGDVTVDLSTNMTMVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=125701 ID09_RS05760 WP_009909965.1 1189941..1190612(-) (ciaR) [Streptococcus suis 6407]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGCCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGCGTTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTGATGT
TGCCTGAAAAAGATGGCTTCCAAGTCTTGAAAGAGTTACGTGAAAAGGGGGTTACGACACCAGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGGGCTGATGACTATTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACCTTTGGAGATGTGACAG
TTGACCTATCTACAAATATGACGATGGTAAATGGCGAAGAAGTTGAACTGCTAGGAAAAGAATTTGATCTACTAGTTTAT
TTCTTGCAAAATCAAAATGTCATTTTGCCAAAAACACAAATTTTTGACCGTATTTGGGGCTTTGACAGTGATACTACAAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTTGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGATACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A075SH40

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.341	100	0.883
ciaR	Streptococcus pneumoniae D39	88.341	100	0.883
ciaR	Streptococcus pneumoniae R6	88.341	100	0.883
ciaR	Streptococcus pneumoniae TIGR4	88.341	100	0.883
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.496	100	0.39
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.363