Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   DK43_RS04990 Genome accession   NZ_CP007573
Coordinates   1034048..1034722 (+) Length   224 a.a.
NCBI ID   WP_003024352.1    Uniprot ID   A0AAI9NIE3
Organism   Streptococcus anginosus strain SA1     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1029048..1039722
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DK43_RS04965 (DK43_05125) - 1030279..1031127 (+) 849 WP_003029580.1 hypothetical protein -
  DK43_RS04970 (DK43_05130) - 1031235..1031531 (-) 297 WP_003024343.1 type II toxin-antitoxin system RelE/ParE family toxin -
  DK43_RS04975 (DK43_05135) - 1031528..1031776 (-) 249 WP_003029583.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
  DK43_RS04980 (DK43_05140) - 1032404..1032934 (+) 531 WP_003029588.1 alpha/beta hydrolase -
  DK43_RS04985 (DK43_05145) - 1033320..1033775 (+) 456 WP_003029592.1 hypothetical protein -
  DK43_RS04990 (DK43_05150) ciaR 1034048..1034722 (+) 675 WP_003024352.1 response regulator transcription factor Regulator
  DK43_RS04995 (DK43_05155) ciaH 1034712..1036058 (+) 1347 WP_003024354.1 HAMP domain-containing sensor histidine kinase Regulator
  DK43_RS05000 (DK43_05160) - 1036565..1038013 (-) 1449 WP_003029597.1 alpha-amylase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25359.01 Da        Isoelectric Point: 4.2408

>NTDB_id=121205 DK43_RS04990 WP_003024352.1 1034048..1034722(+) (ciaR) [Streptococcus anginosus strain SA1]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLIMTA
KESLNDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTVNLSTNTTLVDGNEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNLQTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=121205 DK43_RS04990 WP_003024352.1 1034048..1034722(+) (ciaR) [Streptococcus anginosus strain SA1]
ATGATTAAGATTCTATTAGTAGAAGATGACCTCGGTTTATCTAATTCAGTATTTGACTTTTTGGATGATTTTGCAGATGT
CATGCAAGTTTTTGATGGTGAGGAAGGATTGTATGAGGCTGAGAGTGGCGTATACGACCTTATCTTGCTTGATTTGATGT
TGCCAGAAAAAGACGGCTTCCAAGTGTTGAAAGAATTGCGTGAAAAAGGTGTCACAACTCCTGTGCTAATCATGACAGCC
AAAGAAAGTTTGAATGATAAAGGACATGGTTTTGAACTGGGTGCTGATGATTATTTGACCAAACCATTTTATTTGGAAGA
ATTAAAAATGCGGATTCAAGCTCTGTTGAAGCGTTCTGGCAAGTTTAATGAAAACACCCTTTCTTATGGCGATGTCACTG
TTAATTTATCAACTAACACAACACTTGTAGACGGAAATGAAGTAGAATTGCTCGGAAAAGAATTTGACTTGCTGGTGTAT
TTCTTGCAAAATCAAAATGTCATTTTGCCTAAGACACAGATTTTCGATCGCTTGTGGGGATTTGATAGTGATACAACGAT
TTCAGTTGTAGAAGTTTATGTCTCAAAAATCCGGAAAAAATTGAAAGGGACGACCTTTGCGAACAATCTTCAAACGCTTC
GTAGTGTCGGATATATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

91.964

100

0.92
  ciaR Streptococcus pneumoniae D39

91.964

100

0.92
  ciaR Streptococcus pneumoniae R6

91.964

100

0.92
  ciaR Streptococcus pneumoniae TIGR4

91.964

100

0.92
  ciaR Streptococcus mutans UA159

90.135

99.554

0.897
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.767

100

0.393
  vicR Streptococcus mutans UA159

36.052

100

0.375
  covR Streptococcus salivarius strain HSISS4

35.683

100

0.362

Multiple sequence alignment