Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   DK43_RS04995 Genome accession   NZ_CP007573
Coordinates   1034712..1036058 (+) Length   448 a.a.
NCBI ID   WP_003024354.1    Uniprot ID   -
Organism   Streptococcus anginosus strain SA1     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1029712..1041058
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DK43_RS04965 (DK43_05125) - 1030279..1031127 (+) 849 WP_003029580.1 hypothetical protein -
  DK43_RS04970 (DK43_05130) - 1031235..1031531 (-) 297 WP_003024343.1 type II toxin-antitoxin system RelE/ParE family toxin -
  DK43_RS04975 (DK43_05135) - 1031528..1031776 (-) 249 WP_003029583.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
  DK43_RS04980 (DK43_05140) - 1032404..1032934 (+) 531 WP_003029588.1 alpha/beta hydrolase -
  DK43_RS04985 (DK43_05145) - 1033320..1033775 (+) 456 WP_003029592.1 hypothetical protein -
  DK43_RS04990 (DK43_05150) ciaR 1034048..1034722 (+) 675 WP_003024352.1 response regulator transcription factor Regulator
  DK43_RS04995 (DK43_05155) ciaH 1034712..1036058 (+) 1347 WP_003024354.1 HAMP domain-containing sensor histidine kinase Regulator
  DK43_RS05000 (DK43_05160) - 1036565..1038013 (-) 1449 WP_003029597.1 alpha-amylase -
  DK43_RS05005 (DK43_05165) - 1038190..1039803 (+) 1614 WP_003029598.1 M20/M25/M40 family metallo-hydrolase -
  DK43_RS05010 (DK43_05170) - 1039851..1040360 (-) 510 WP_003029599.1 DNA topology modulation protein -
  DK43_RS05015 (DK43_05175) rpsT 1040425..1040676 (-) 252 WP_020999623.1 30S ribosomal protein S20 -

Sequence

Protein


Download         Length: 448 a.a.        Molecular weight: 51038.78 Da        Isoelectric Point: 10.1380

>NTDB_id=121206 DK43_RS04995 WP_003024354.1 1034712..1036058(+) (ciaH) [Streptococcus anginosus strain SA1]
MLNKLKKTWYADDFSYFIRNFGIFTLIFSAMTLIIIQVMRSSLYTTVDNNLKSLSQDSASVINLALARRVGMEQKSDNGE
PKTDTGDKELTDKPNVSANTEVILFDKNYKPIITSNNFLGLNKLSFNSKQLDRIRQVQVKSNYGRQETYRMILFEVKIPN
LETNVKYAAVFINISQLEQTSQNHEQLIVVVMISFWGISLIASVYLARVSVKPLLESIQKQKSFVENASHELRTPLAVLQ
NRLETLFRKPEATIMESSESIASSLDEVRNMKMLTTNLLNLARRDDGIKPEIGDVEPNFFNTTFTNYEMVAAENGKTFRF
DNRIHRMIKTDKTLLKQLMTILFDNALKYTDEDGVIELTISANDRNLFLKVSDNGPGISTADKKKIFDRFYRVDKARTRQ
TGGFGLGLSLAKQITEALKGTITVKDNKPKGTIFEVKIAIRTDNRKKK

Nucleotide


Download         Length: 1347 bp        

>NTDB_id=121206 DK43_RS04995 WP_003024354.1 1034712..1036058(+) (ciaH) [Streptococcus anginosus strain SA1]
ATGCTGAATAAACTAAAAAAAACATGGTATGCGGATGATTTTTCTTATTTCATTCGCAATTTTGGTATTTTTACTCTCAT
TTTCTCAGCCATGACTTTGATTATCATTCAGGTGATGCGCTCAAGCCTTTATACAACGGTTGATAATAACTTGAAAAGTC
TCAGTCAGGATTCTGCTTCTGTCATCAATTTGGCACTCGCTCGGAGAGTGGGGATGGAACAGAAGTCAGACAACGGAGAG
CCTAAAACCGATACGGGTGACAAAGAGCTTACTGATAAACCAAATGTCAGTGCCAATACGGAAGTTATTTTATTTGATAA
GAATTATAAGCCAATCATTACAAGCAATAATTTTCTGGGACTTAATAAACTTTCCTTTAATAGCAAGCAATTGGATCGCA
TTCGGCAAGTCCAGGTTAAAAGCAATTATGGTCGACAAGAAACCTATCGGATGATTTTATTTGAAGTGAAAATCCCAAAT
TTGGAAACCAATGTCAAATATGCAGCGGTCTTTATCAATATCAGTCAGTTGGAACAAACTAGTCAAAATCATGAGCAGCT
GATTGTAGTTGTGATGATTAGTTTCTGGGGAATTTCCTTGATTGCCAGTGTCTATCTGGCTCGGGTTAGTGTTAAACCTT
TGTTGGAGAGTATTCAAAAGCAAAAGAGCTTTGTTGAAAATGCCAGTCATGAGTTGCGCACGCCTCTAGCTGTTTTACAA
AATCGTTTGGAGACTTTGTTTAGAAAACCAGAAGCCACCATTATGGAATCGAGTGAAAGCATCGCTTCTAGTTTAGATGA
AGTGCGAAACATGAAAATGTTGACAACGAACTTACTTAATTTAGCACGGCGTGACGACGGGATTAAACCAGAAATTGGCG
ATGTCGAGCCAAATTTCTTTAATACGACCTTTACCAACTATGAAATGGTTGCCGCAGAAAATGGGAAAACTTTCCGATTT
GACAATAGGATTCACCGCATGATTAAAACAGACAAGACCTTGCTGAAGCAATTAATGACGATTCTGTTTGACAATGCTCT
GAAATATACAGATGAAGACGGTGTGATTGAATTGACAATCTCTGCAAATGATCGAAATTTGTTTTTAAAGGTTTCAGATA
ATGGTCCGGGGATTAGTACGGCAGATAAGAAAAAGATTTTTGATCGTTTTTATCGGGTTGATAAAGCACGGACTCGGCAG
ACAGGTGGTTTTGGTCTAGGCTTGTCGCTTGCAAAGCAAATCACAGAAGCTCTTAAAGGAACTATTACGGTGAAAGATAA
TAAGCCGAAAGGAACTATTTTTGAGGTGAAGATTGCCATTAGAACGGATAATAGAAAGAAAAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(331-438)

His Kinase A (phospho-acceptor) domain (HisKA)

(222-287)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

71.429

100

0.714
  ciaH Streptococcus pneumoniae D39

71.429

100

0.714
  ciaH Streptococcus pneumoniae R6

71.429

100

0.714
  ciaH Streptococcus pneumoniae TIGR4

71.429

100

0.714
  ciaH Streptococcus mutans UA159

56.009

98.438

0.551

Multiple sequence alignment