Detailed information NTG0121176

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: DX05_RS10020
• Genome accession: NZ_CP007572
• Coordinates: 2017228..2017980 (-)
• Length: 250 a.a.
• NCBI ID: WP_001019933.1
• Uniprot ID: -
• Organism: Streptococcus agalactiae strain GBS6
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 2012228..2022980

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DX05_RS09990 (DX05_10125)	-	2012287..2012778 (-)	492	WP_000632641.1	PTS sugar transporter subunit IIB	-
DX05_RS09995 (DX05_10130)	-	2012795..2013220 (-)	426	WP_000823122.1	PTS mannose transporter subunit IIA	-
DX05_RS10000 (DX05_10135)	-	2013467..2014501 (-)	1035	WP_000369170.1	acyltransferase family protein	-
DX05_RS10005 (DX05_10140)	-	2014730..2015884 (-)	1155	WP_000623422.1	ABC transporter permease subunit	-
DX05_RS10010 (DX05_10145)	-	2015890..2016738 (-)	849	WP_000926587.1	ABC transporter ATP-binding protein	-
DX05_RS12410	-	2016861..2017159 (-)	299	Protein_1916	GHKL domain-containing protein	-
DX05_RS10020 (DX05_10160)	comE/blpR	2017228..2017980 (-)	753	WP_001019933.1	LytTR family transcriptional regulator DNA-binding domain-containing protein	Regulator
DX05_RS10025 (DX05_10165)	-	2018257..2019072 (-)	816	WP_001029865.1	endonuclease/exonuclease/phosphatase family protein	-
DX05_RS10030 (DX05_10170)	-	2019126..2021309 (-)	2184	WP_000795066.1	PTS transporter subunit IIBC	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29688.18 Da
• Isoelectric Point: 6.4980

>NTDB_id=121176 DX05_RS10020 WP_001019933.1 2017228..2017980(-) (comE/blpR) [Streptococcus agalactiae strain GBS6]
MNIFILEDDFVQQAHLEKIIKEIRVQYNLHFKTVETFAKPVQLLESIYEIGLHNLFFLDIEIKNDEQIGLEVAKQIRQVD
PYAQIVFVTTHSELMPLTFRYQVSALDYIDKGLSQEEFSQRIEEVLLYVDGICNKPLVENSFYFKSRYSQVQLPFNDLLY
IETSSRSHRVVLYTEKDRMEFTATLGDILKQEPRLFQCHRSFLVNPLNIFKVDRIDRLVYFQNGTTCLISRNKVRDIVSI
VDKYQKDRKR

Nucleotide

• Length: 753 bp

>NTDB_id=121176 DX05_RS10020 WP_001019933.1 2017228..2017980(-) (comE/blpR) [Streptococcus agalactiae strain GBS6]
GTGAATATTTTTATACTTGAGGATGATTTTGTTCAACAAGCCCATTTGGAAAAAATCATTAAAGAGATTAGAGTACAGTA
CAATCTGCATTTCAAAACAGTAGAAACGTTTGCTAAACCAGTTCAATTATTGGAGTCAATTTATGAAATAGGTTTGCATA
ATTTATTTTTCTTAGATATTGAAATAAAAAACGATGAGCAGATAGGCTTAGAGGTCGCAAAACAAATTAGACAAGTTGAT
CCTTATGCTCAGATTGTTTTTGTTACAACTCATTCAGAATTAATGCCTTTAACCTTTCGTTATCAGGTATCAGCTTTAGA
CTATATCGATAAAGGACTTTCACAGGAAGAGTTTAGCCAAAGGATTGAGGAAGTATTGTTGTACGTAGATGGCATTTGCA
ATAAGCCCTTAGTGGAAAATTCATTCTACTTTAAGTCGCGTTACAGCCAGGTACAATTACCTTTTAACGATCTTCTTTAT
ATAGAAACATCCTCAAGATCACATAGAGTTGTCCTTTATACTGAAAAAGATAGAATGGAATTCACAGCCACTTTGGGGGA
TATTTTAAAACAAGAACCTAGGCTCTTTCAATGTCATCGCTCTTTTTTAGTAAATCCCTTAAATATTTTTAAAGTGGATA
GGATAGATAGATTAGTTTACTTCCAAAATGGAACGACTTGTCTGATTTCACGCAATAAAGTGAGAGATATAGTATCTATA
GTGGATAAATATCAAAAGGATAGAAAAAGATGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-238)

• Response regulator receiver domain (Response_reg) (3-122)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.306	96.8	0.516
comE/comE1	Streptococcus equinus JB1	41.152	97.2	0.4
comE	Streptococcus infantis strain Atu-4	37.849	100	0.38
comE	Streptococcus mitis NCTC 12261	38	100	0.38
comE	Streptococcus mitis SK321	38	100	0.38
comE	Streptococcus pneumoniae R6	37.5	99.2	0.372
comE	Streptococcus pneumoniae TIGR4	37.5	99.2	0.372
comE	Streptococcus pneumoniae Rx1	37.5	99.2	0.372
comE	Streptococcus pneumoniae D39	37.5	99.2	0.372