Detailed information    

insolico Bioinformatically predicted

Overview

Name   prx   Type   Regulator
Locus tag   STAB1101_RS04660 Genome accession   NZ_CP007240
Coordinates   939959..940147 (-) Length   62 a.a.
NCBI ID   WP_011054546.1    Uniprot ID   A0A5S4TJS4
Organism   Streptococcus pyogenes strain 7F7     
Function   Inhibit ComR activation (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 932371..963391 939959..940147 within 0


Gene organization within MGE regions


Location: 932371..963391
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  STAB1101_RS04630 (STAB1101_04630) pfkA 932371..933384 (-) 1014 WP_002984444.1 6-phosphofructokinase -
  STAB1101_RS04635 (STAB1101_04635) - 933464..936574 (-) 3111 WP_002984441.1 DNA polymerase III subunit alpha -
  STAB1101_RS04640 (STAB1101_04640) - 936759..937130 (+) 372 WP_002989617.1 GntR family transcriptional regulator -
  STAB1101_RS04645 (STAB1101_04645) - 937130..937828 (+) 699 WP_002992425.1 ABC transporter ATP-binding protein -
  STAB1101_RS04650 (STAB1101_04650) - 937838..938623 (+) 786 WP_002984433.1 hypothetical protein -
  STAB1101_RS04655 (STAB1101_04655) - 938754..939368 (-) 615 WP_002989607.1 TVP38/TMEM64 family protein -
  STAB1101_RS04660 (STAB1101_04660) prx 939959..940147 (-) 189 WP_011054546.1 hypothetical protein Regulator
  STAB1101_RS04665 (STAB1101_04665) spel 940262..941050 (-) 789 WP_020833516.1 streptococcal pyrogenic exotoxin SpeL -
  STAB1101_RS04670 (STAB1101_04670) spem 941332..942045 (-) 714 WP_038431384.1 streptococcal pyrogenic exotoxin SpeM -
  STAB1101_RS04675 (STAB1101_04675) - 942349..943215 (-) 867 WP_038431386.1 DUF334 domain-containing protein -
  STAB1101_RS04680 (STAB1101_04680) - 943203..943727 (-) 525 WP_011017840.1 Panacea domain-containing protein -
  STAB1101_RS04685 (STAB1101_04685) - 943867..945075 (-) 1209 WP_038431388.1 glucosaminidase domain-containing protein -
  STAB1101_RS04695 (STAB1101_04695) - 945191..945418 (-) 228 WP_000609113.1 phage holin -
  STAB1101_RS04700 (STAB1101_04700) - 945415..945690 (-) 276 WP_002987582.1 hypothetical protein -
  STAB1101_RS04705 (STAB1101_04705) - 945700..946317 (-) 618 WP_038431396.1 DUF1366 domain-containing protein -
  STAB1101_RS08470 - 946320..946481 (-) 162 WP_002987333.1 hypothetical protein -
  STAB1101_RS04710 (STAB1101_04710) - 946495..947640 (-) 1146 Protein_894 gp58-like family protein -
  STAB1101_RS09040 - 947661..947892 (-) 232 Protein_895 hypothetical protein -
  STAB1101_RS04715 (STAB1101_04715) - 947889..948245 (-) 357 WP_032462868.1 hypothetical protein -
  STAB1101_RS04720 (STAB1101_04720) - 948229..948513 (-) 285 WP_011017874.1 VRR-NUC domain-containing protein -
  STAB1101_RS04725 (STAB1101_04725) - 948533..949402 (-) 870 WP_020833541.1 bifunctional DNA primase/polymerase -
  STAB1101_RS04730 (STAB1101_04730) - 949680..951233 (-) 1554 WP_002984332.1 hypothetical protein -
  STAB1101_RS04735 (STAB1101_04735) - 951251..951733 (-) 483 WP_002984328.1 DUF669 domain-containing protein -
  STAB1101_RS04740 (STAB1101_04740) - 951738..953171 (-) 1434 Protein_901 DEAD/DEAH box helicase -
  STAB1101_RS04745 (STAB1101_04745) - 953177..953860 (-) 684 WP_002984321.1 AAA family ATPase -
  STAB1101_RS04750 (STAB1101_04750) - 953857..954141 (-) 285 WP_002984318.1 hypothetical protein -
  STAB1101_RS04755 (STAB1101_04755) - 954138..954332 (-) 195 WP_002984315.1 hypothetical protein -
  STAB1101_RS04760 (STAB1101_04760) - 954332..954661 (-) 330 WP_002984312.1 hypothetical protein -
  STAB1101_RS08480 - 954742..954879 (-) 138 WP_002984309.1 hypothetical protein -
  STAB1101_RS04765 (STAB1101_04765) - 954876..955172 (-) 297 WP_011017882.1 MerR family transcriptional regulator -
  STAB1101_RS04770 (STAB1101_04770) - 955250..955426 (-) 177 WP_002995990.1 helix-turn-helix domain-containing protein -
  STAB1101_RS04775 (STAB1101_04775) - 955569..955787 (+) 219 WP_023079659.1 hypothetical protein -
  STAB1101_RS04780 (STAB1101_04780) - 955963..956172 (+) 210 WP_002984292.1 hypothetical protein -
  STAB1101_RS04790 (STAB1101_04790) - 956431..956940 (+) 510 WP_011017884.1 hypothetical protein -
  STAB1101_RS04795 (STAB1101_04795) - 957071..957280 (+) 210 WP_011017885.1 hypothetical protein -
  STAB1101_RS04800 (STAB1101_04800) - 957390..957590 (-) 201 WP_002992770.1 helix-turn-helix domain-containing protein -
  STAB1101_RS04805 (STAB1101_04805) - 957664..958050 (+) 387 WP_011054589.1 hypothetical protein -
  STAB1101_RS04810 (STAB1101_04810) - 958039..958248 (-) 210 WP_038431402.1 hypothetical protein -
  STAB1101_RS04815 (STAB1101_04815) - 958302..958901 (+) 600 WP_011284882.1 hypothetical protein -
  STAB1101_RS08485 - 958931..959089 (-) 159 WP_011285583.1 hypothetical protein -
  STAB1101_RS04820 (STAB1101_04820) - 959446..960270 (+) 825 WP_011285584.1 XRE family transcriptional regulator -
  STAB1101_RS04825 (STAB1101_04825) - 960306..961199 (+) 894 WP_038431403.1 P63C domain-containing protein -
  STAB1101_RS04830 (STAB1101_04830) - 961320..962408 (+) 1089 WP_011054595.1 site-specific integrase -
  STAB1101_RS04835 (STAB1101_04835) - 962771..963391 (+) 621 WP_002989605.1 DUF3862 domain-containing protein -

Sequence

Protein


Download         Length: 62 a.a.        Molecular weight: 7226.17 Da        Isoelectric Point: 3.9947

>NTDB_id=118037 STAB1101_RS04660 WP_011054546.1 939959..940147(-) (prx) [Streptococcus pyogenes strain 7F7]
MLTYDEFKQAIDDGYIVGDTVMIVRKNGQIFDYVLPHEEARNGEVVTEEKVEEVMVELDYIK

Nucleotide


Download         Length: 189 bp        

>NTDB_id=118037 STAB1101_RS04660 WP_011054546.1 939959..940147(-) (prx) [Streptococcus pyogenes strain 7F7]
ATGCTAACATACGACGAATTTAAGCAAGCTATTGATGACGGATATATCGTAGGAGACACAGTTATGATCGTGCGTAAAAA
CGGACAGATTTTTGATTATGTGTTGCCGCATGAGGAAGCGAGAAATGGAGAAGTTGTGACAGAGGAGAAGGTGGAAGAAG
TGATGGTGGAATTAGACTATATCAAATGA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5S4TJS4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  prx Streptococcus pyogenes MGAS315

100

100

1
  prx Streptococcus pyogenes MGAS315

84.746

95.161

0.806
  prx Streptococcus pyogenes MGAS8232

84.483

93.548

0.79
  prx Streptococcus pyogenes MGAS315

82.759

93.548

0.774
  prx Streptococcus pyogenes MGAS315

77.966

95.161

0.742
  prx Streptococcus pyogenes MGAS315

87.805

66.129

0.581
  prx Streptococcus pyogenes MGAS315

76.19

67.742

0.516

Multiple sequence alignment