Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   DYB47_RS05295 Genome accession   NZ_UHFV01000002
Coordinates   1024521..1025195 (-) Length   224 a.a.
NCBI ID   WP_003081988.1    Uniprot ID   G5JVD4
Organism   Streptococcus macacae NCTC 11558     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1019521..1030195
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DYB47_RS05270 (NCTC11558_01064) - 1019910..1021187 (-) 1278 WP_003080077.1 pyrimidine-nucleoside phosphorylase -
  DYB47_RS05275 (NCTC11558_01065) - 1021174..1021773 (-) 600 WP_003082322.1 class I SAM-dependent methyltransferase -
  DYB47_RS05280 (NCTC11558_01066) coaA 1021866..1022786 (+) 921 WP_003078607.1 type I pantothenate kinase -
  DYB47_RS05285 (NCTC11558_01067) rpsT 1022840..1023091 (+) 252 WP_081479315.1 30S ribosomal protein S20 -
  DYB47_RS05290 (NCTC11558_01068) ciaH 1023218..1024531 (-) 1314 WP_003079730.1 sensor histidine kinase Regulator
  DYB47_RS05295 (NCTC11558_01069) ciaR 1024521..1025195 (-) 675 WP_003081988.1 response regulator transcription factor Regulator
  DYB47_RS05300 (NCTC11558_01070) - 1025364..1027910 (-) 2547 WP_003080305.1 M1 family metallopeptidase -
  DYB47_RS05305 (NCTC11558_01071) phoU 1027953..1028606 (-) 654 WP_003078547.1 phosphate signaling complex protein PhoU -
  DYB47_RS05310 (NCTC11558_01072) pstB 1028629..1029387 (-) 759 WP_003080953.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25527.21 Da        Isoelectric Point: 4.3425

>NTDB_id=1171318 DYB47_RS05295 WP_003081988.1 1024521..1025195(-) (ciaR) [Streptococcus macacae NCTC 11558]
MIKLLLVEDDVSLSNSIFDFLDNFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKNISTPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKLTDNNLSYDQLQVDTATNTVTVGGKEIEFLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTLSVVEVYVSKLRKKLKNTEFGKNLETLRSVGYILRNAN

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1171318 DYB47_RS05295 WP_003081988.1 1024521..1025195(-) (ciaR) [Streptococcus macacae NCTC 11558]
ATGATAAAGTTATTATTAGTAGAAGATGACGTCAGTCTTTCTAACTCAATTTTTGATTTTTTAGATAATTTTGCAGATGT
TATGCAGGTTTTTGATGGAGAAGAAGGCTTGTACGAAGCAGAAAGCGGTGTCTATGATCTCATTTTATTAGATCTTATGC
TGCCAGAAAAAGATGGTTTTCAGGTTTTAAAGGAACTGCGCGAAAAAAATATTTCAACCCCGGTGCTTATTATGACAGCT
AAAGAAGGACTGGATGATAAAGGACATGGATTCGAATTAGGGGCAGATGATTATTTGACGAAACCGTTTTATTTAGAGGA
ACTCAAGATGCGTATTCAAGCGCTGTTGAAGCGTTCTGGCAAATTAACTGACAATAATCTATCGTACGATCAATTGCAAG
TTGATACAGCGACGAATACAGTAACGGTAGGGGGAAAAGAGATTGAATTCCTTGGGAAAGAATTTGATTTATTGGTTTAC
TTCCTTCAAAATCAAAATGTTATCTTACCAAAGTCACAGATCTTTGATCGTATCTGGGGATTTGATAGTGATACGACCTT
GTCTGTTGTTGAGGTATATGTTTCAAAACTAAGGAAAAAACTAAAAAACACTGAGTTTGGTAAAAATTTGGAGACATTGC
GCAGTGTAGGGTATATTTTAAGAAATGCTAACTAG

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(5-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB G5JVD4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

89.286

100

0.893
  ciaR Streptococcus pneumoniae Rx1

81.25

100

0.813
  ciaR Streptococcus pneumoniae D39

81.25

100

0.813
  ciaR Streptococcus pneumoniae R6

81.25

100

0.813
  ciaR Streptococcus pneumoniae TIGR4

81.25

100

0.813
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.946

100

0.379
  micA Streptococcus pneumoniae Cp1015

34.454

100

0.366
  vicR Streptococcus mutans UA159

34.615

100

0.362

Multiple sequence alignment