Detailed information NTG1170447

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: ACLV7W_RS05730
• Genome accession: NZ_OZ217346
• Coordinates: 1180796..1181503 (-)
• Length: 235 a.a.
• NCBI ID: WP_000722072.1
• Uniprot ID: A0A3R9LLL2
• Organism: Streptococcus mitis isolate S. mitis D22
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1175796..1186503

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7W_RS05700 (SMID22_11710)	-	1176850..1177197 (+)	348	WP_411865610.1	thioredoxin	-
ACLV7W_RS05705 (SMID22_11720)	-	1177235..1178008 (-)	774	WP_049544233.1	potassium channel family protein	-
ACLV7W_RS05710 (SMID22_11730)	-	1178054..1178308 (-)	255	WP_004254226.1	type II toxin-antitoxin system RelE family toxin	-
ACLV7W_RS05715 (SMID22_11740)	relB	1178310..1178552 (-)	243	WP_000208079.1	type II toxin-antitoxin system RelB family antitoxin	-
ACLV7W_RS05720 (SMID22_11750)	vicX	1178643..1179452 (-)	810	WP_004254224.1	MBL fold metallo-hydrolase	Regulator
ACLV7W_RS05725 (SMID22_11760)	micB	1179445..1180803 (-)	1359	WP_411865611.1	cell wall metabolism sensor histidine kinase VicK	Regulator
ACLV7W_RS05730 (SMID22_11770)	micA	1180796..1181503 (-)	708	WP_000722072.1	response regulator YycF	Regulator
ACLV7W_RS05735 (SMID22_11780)	mutY	1181559..1182734 (-)	1176	WP_411865612.1	A/G-specific adenine glycosylase	-
ACLV7W_RS05740 (SMID22_11790)	pta	1182817..1183791 (-)	975	WP_000451580.1	phosphate acetyltransferase	-
ACLV7W_RS05745 (SMID22_11800)	-	1183835..1184731 (-)	897	WP_084930135.1	RluA family pseudouridine synthase	-
ACLV7W_RS05750 (SMID22_11810)	-	1184728..1185546 (-)	819	WP_049544217.1	NAD kinase	-
ACLV7W_RS05755 (SMID22_11820)	-	1185530..1186201 (-)	672	WP_000171682.1	GTP pyrophosphokinase	-

Sequence

Protein

• Length: 235 a.a.
• Molecular weight: 27107.90 Da
• Isoelectric Point: 4.6177

>NTDB_id=1170447 ACLV7W_RS05730 WP_000722072.1 1180796..1181503(-) (micA) [Streptococcus mitis isolate S. mitis D22]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPIIMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRTDLVSVDNQESDEKKTQPLQIGDLEIVPDAYVAKKYGEELDL
THREFELLYHLASHIGQVITREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMRNND

Nucleotide

• Length: 708 bp

>NTDB_id=1170447 ACLV7W_RS05730 WP_000722072.1 1180796..1181503(-) (micA) [Streptococcus mitis isolate S. mitis D22]
ATGAAAAAAATATTAATTGTAGATGATGAAAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
GGTTGTAACTGCTTTTAATGGTCGTGAAGCACTAGAACAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCCGAAATTGATGGTTTAGAAGTTGCAAAGACTATTCGTAAGACGAGTAGTGTTCCTATTATCATGCTGTCAGCT
AAAGACAGCGAATTTGATAAGGTTATTGGTTTGGAGCTTGGAGCGGATGACTATGTGACAAAACCCTTCTCAAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTTCGTCGTACGGACTTGGTTTCTGTAGATAATCAAGAGTCAGATGAAAAGAAAA
CCCAACCCTTGCAAATTGGGGACTTAGAGATTGTTCCAGATGCCTACGTGGCTAAAAAATATGGTGAAGAACTAGACTTA
ACCCACCGTGAATTTGAACTTTTGTACCACTTGGCTTCTCATATTGGTCAAGTGATTACCCGTGAACACTTGCTTGAAAC
GGTCTGGGGGTATGATTATTTCGGAGATGTTCGGACTGTTGACGTAACTATCAGACGTTTGCGTGAGAAGATTGAAGATA
CACCTAGTCGTCCAGAGTATATCCTAACACGTCGTGGTGTTGGTTATTATATGAGAAATAATGATTGA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (155-230)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: A0A3R9LLL2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	94.017	99.574	0.936
vicR	Streptococcus mutans UA159	77.447	100	0.774
covR	Streptococcus salivarius strain HSISS4	44.589	98.298	0.438
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.723	98.298	0.43
scnR	Streptococcus mutans UA159	38.034	99.574	0.379