Detailed information NTG1170299

Bioinformatically predicted

Overview

• Name: clpP
• Type: Regulator
• Locus tag: ACLV7A_RS06910
• Genome accession: NZ_OZ217344
• Coordinates: 1395679..1396269 (-)
• Length: 196 a.a.
• NCBI ID: WP_000613475.1
• Uniprot ID: F9HD24
• Organism: Streptococcus mitis isolate S. mitis E22
• Function: degradation of ComX; degradation of ComW (predicted from homology) Competence regulation

Genomic Context

Location: 1390679..1401269

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7A_RS06885 (SMIE22_13540)	-	1391381..1392145 (-)	765	WP_001185997.1	ABC transporter ATP-binding protein	-
ACLV7A_RS06890 (SMIE22_13550)	-	1392145..1393101 (-)	957	WP_411863935.1	branched-chain amino acid ABC transporter permease	-
ACLV7A_RS06895 (SMIE22_13560)	-	1393105..1393974 (-)	870	WP_000941427.1	branched-chain amino acid ABC transporter permease	-
ACLV7A_RS06900 (SMIE22_13570)	-	1394090..1395250 (-)	1161	WP_173225327.1	ABC transporter substrate-binding protein	-
ACLV7A_RS06905 (SMIE22_13580)	-	1395334..1395600 (-)	267	WP_050223575.1	YlbG family protein	-
ACLV7A_RS06910 (SMIE22_13590)	clpP	1395679..1396269 (-)	591	WP_000613475.1	ATP-dependent Clp protease proteolytic subunit ClpP	Regulator
ACLV7A_RS06915 (SMIE22_13600)	upp	1396442..1397071 (-)	630	WP_000515974.1	uracil phosphoribosyltransferase	-
ACLV7A_RS06920 (SMIE22_13610)	-	1397160..1397627 (-)	468	WP_000136977.1	deoxycytidylate deaminase	-
ACLV7A_RS06925 (SMIE22_13620)	-	1397646..1398203 (-)	558	WP_000004132.1	TetR/AcrR family transcriptional regulator	-
ACLV7A_RS06930 (SMIE22_13630)	-	1398328..1399173 (+)	846	WP_261041235.1	DegV family protein	-
ACLV7A_RS06935 (SMIE22_13640)	-	1399231..1400403 (+)	1173	WP_411863936.1	NAD(P)/FAD-dependent oxidoreductase	-
ACLV7A_RS06940 (SMIE22_13650)	-	1400453..1400974 (+)	522	WP_411863937.1	DUF1697 domain-containing protein	-

Sequence

Protein

• Length: 196 a.a.
• Molecular weight: 21340.32 Da
• Isoelectric Point: 4.4910

>NTDB_id=1170299 ACLV7A_RS06910 WP_000613475.1 1395679..1396269(-) (clpP) [Streptococcus mitis isolate S. mitis E22]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQ
SIEKVHADAERDNWMSAQETLEYGFIDEIMANNSLN

Nucleotide

• Length: 591 bp

>NTDB_id=1170299 ACLV7A_RS06910 WP_000613475.1 1395679..1396269(-) (clpP) [Streptococcus mitis isolate S. mitis E22]
ATGATTCCTGTAGTTATTGAACAAACAAGCCGTGGAGAACGTTCTTACGATATTTACTCACGTCTTCTCAAAGACCGCAT
CATTATGCTGACAGGTCCAGTTGAAGACAATATGGCTAACTCTGTTATTGCCCAATTGCTTTTTTTAGATGCCCAAGATA
GTACAAAAGATATTTACCTTTATGTCAATACACCTGGGGGTTCTGTTTCAGCTGGTTTGGCAATCGTAGATACCATGAAC
TTTATCAAAGCGGATGTCCAAACCATCGTTATGGGGATGGCTGCATCTATGGGTACTGTCATCGCATCAAGTGGAGCAAA
GGGCAAACGTTTCATGCTTCCAAATGCTGAGTACATGATCCACCAACCAATGGGTGGTACAGGTGGTGGTACTCAACAAA
CTGATATGGCGATCGCTGCAGAACACTTGCTTAAAACTCGTAATACCTTGGAAAAAATCTTGGCTGAAAATTCAGGTCAG
TCAATCGAGAAAGTCCACGCAGATGCAGAACGCGATAACTGGATGAGTGCTCAAGAAACACTTGAATATGGCTTTATTGA
TGAAATCATGGCCAACAATTCATTGAACTAA

Domains

Predicted by InterproScan.

• Clp protease (CLP_protease) (11-192)

3D structure

• AlphaFold DB: F9HD24

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpP	Streptococcus pneumoniae Rx1	99.49	100	0.995
clpP	Streptococcus pneumoniae D39	99.49	100	0.995
clpP	Streptococcus pneumoniae R6	99.49	100	0.995
clpP	Streptococcus pneumoniae TIGR4	99.49	100	0.995
clpP	Streptococcus thermophilus LMG 18311	93.333	99.49	0.929
clpP	Streptococcus thermophilus LMD-9	93.333	99.49	0.929
clpP	Streptococcus pyogenes JRS4	91.282	99.49	0.908
clpP	Streptococcus pyogenes MGAS315	91.282	99.49	0.908
clpP	Streptococcus mutans UA159	86.224	100	0.862
clpP	Lactococcus lactis subsp. lactis strain DGCC12653	85.128	99.49	0.847
clpP	Lactococcus lactis subsp. cremoris KW2	84.615	99.49	0.842
clpP	Bacillus subtilis subsp. subtilis str. 168	58.854	97.959	0.577
clpP	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	58.031	98.469	0.571