Detailed information NTG1170206

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: ACLV7Z_RS04835
• Genome accession: NZ_OZ217343
• Coordinates: 980639..981343 (+)
• Length: 234 a.a.
• NCBI ID: WP_050259789.1
• Uniprot ID: A0A0T8U7H7
• Organism: Streptococcus mitis isolate S. mitis G22
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 975639..986343

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7Z_RS04810 (SMIG22_09370)	coaC	975759..976310 (-)	552	WP_218774833.1	phosphopantothenoylcysteine decarboxylase	-
ACLV7Z_RS04815 (SMIG22_09380)	coaB	976322..977011 (-)	690	WP_218774834.1	phosphopantothenate--cysteine ligase	-
ACLV7Z_RS04820 (SMIG22_09390)	-	977244..978914 (+)	1671	WP_218774835.1	formate--tetrahydrofolate ligase	-
ACLV7Z_RS04825 (SMIG22_09400)	-	979035..979322 (-)	288	WP_218774836.1	hypothetical protein	-
ACLV7Z_RS04830 (SMIG22_09410)	mutY	979408..980583 (+)	1176	WP_218774837.1	A/G-specific adenine glycosylase	-
ACLV7Z_RS04835 (SMIG22_09420)	micA	980639..981343 (+)	705	WP_050259789.1	response regulator YycF	Regulator
ACLV7Z_RS04840 (SMIG22_09430)	micB	981336..982685 (+)	1350	WP_050090938.1	cell wall metabolism sensor histidine kinase VicK	Regulator
ACLV7Z_RS04845 (SMIG22_09440)	vicX	982687..983496 (+)	810	WP_218774838.1	MBL fold metallo-hydrolase	Regulator
ACLV7Z_RS04850 (SMIG22_09450)	relB	983587..983829 (+)	243	WP_050223090.1	type II toxin-antitoxin system RelB family antitoxin	-
ACLV7Z_RS04855 (SMIG22_09460)	-	983831..984085 (+)	255	WP_007284771.1	type II toxin-antitoxin system RelE family toxin	-
ACLV7Z_RS04860 (SMIG22_09470)	-	984159..986042 (+)	1884	WP_218774839.1	Eco57I restriction-modification methylase domain-containing protein	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=1170206 ACLV7Z_RS04835 WP_050259789.1 980639..981343(+) (micA) [Streptococcus mitis isolate S. mitis G22]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPIIMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=1170206 ACLV7Z_RS04835 WP_050259789.1 980639..981343(+) (micA) [Streptococcus mitis isolate S. mitis G22]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
GGTTGTAACTGCTTTTAACGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAGCCAGATATTATTATTCTGGATTTGA
TGCTTCCGGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGCAAGACAAGTAGTGTACCTATTATCATGCTGTCGGCT
AAAGACAGTGAATTTGATAAGGTTATCGGTTTAGAGCTTGGAGCAGATGACTATGTAACCAAACCCTTCTCCAATCGTGA
GTTACAGGCGCGTGTTAAAGCTTTGCTGCGTCGTTCTCAACCTATGCCAGTAGATGGGCAGGAAGCAGATAGCAAACCTC
AGCCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CACCGTGAGTTTGAGCTTTTGTATCATTTGGCATCGCATACAGGTCAAGTCATTACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTCCGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: A0A0T8U7H7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	99.573	100	0.996
vicR	Streptococcus mutans UA159	78.97	99.573	0.786
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.913	98.291	0.432
scnR	Streptococcus mutans UA159	37.768	99.573	0.376