Detailed information NTG1170122

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: ACLV65_RS04795
• Genome accession: NZ_OZ217342
• Coordinates: 942287..942991 (+)
• Length: 234 a.a.
• NCBI ID: WP_411864683.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis B22
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 937287..947991

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV65_RS04770 (SMIB22_09300)	coaC	937541..938092 (-)	552	WP_411864679.1	phosphopantothenoylcysteine decarboxylase	-
ACLV65_RS04775 (SMIB22_09310)	coaB	938104..938793 (-)	690	WP_411864680.1	phosphopantothenate--cysteine ligase	-
ACLV65_RS04780 (SMIB22_09320)	-	939026..940696 (+)	1671	WP_411864681.1	formate--tetrahydrofolate ligase	-
ACLV65_RS04785 (SMIB22_09330)	-	940812..940970 (-)	159	WP_240149564.1	hypothetical protein	-
ACLV65_RS04790 (SMIB22_09340)	mutY	941056..942231 (+)	1176	WP_411864682.1	A/G-specific adenine glycosylase	-
ACLV65_RS04795 (SMIB22_09350)	micA	942287..942991 (+)	705	WP_411864683.1	response regulator YycF	Regulator
ACLV65_RS04800 (SMIB22_09360)	micB	942984..944333 (+)	1350	WP_050090938.1	cell wall metabolism sensor histidine kinase VicK	Regulator
ACLV65_RS04805 (SMIB22_09370)	vicX	944335..945144 (+)	810	WP_050302726.1	MBL fold metallo-hydrolase	Regulator
ACLV65_RS04810 (SMIB22_09380)	relB	945235..945477 (+)	243	WP_172930976.1	type II toxin-antitoxin system RelB family antitoxin	-
ACLV65_RS04815 (SMIB22_09390)	-	945479..945733 (+)	255	WP_033684234.1	type II toxin-antitoxin system RelE family toxin	-
ACLV65_RS04820 (SMIB22_09400)	-	945809..947707 (+)	1899	WP_411864684.1	Eco57I restriction-modification methylase domain-containing protein	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26762.58 Da
• Isoelectric Point: 4.6466

>NTDB_id=1170122 ACLV65_RS04795 WP_411864683.1 942287..942991(+) (micA) [Streptococcus mitis isolate S. mitis B22]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGCEALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPIIMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=1170122 ACLV65_RS04795 WP_411864683.1 942287..942991(+) (micA) [Streptococcus mitis isolate S. mitis B22]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAACGGTTGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCGGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGCAAGACAAGTAGTGTACCTATTATCATGCTGTCGGCT
AAAGACAGCGAATTTGATAAGGTCATCGGTTTGGAGCTTGGGGCAGATGACTATGTGACAAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTTCGTCGTTCTCAACCTATGCCAGTAGATGGGCAGGAAGCAGATAGCAAACCTC
AGCCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CACCGTGAGTTTGAGCTTTTGTATCATTTGGCATCACATACAGGTCAAGTCATTACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACGGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	99.145	100	0.991
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	43.723	98.718	0.432
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	37.768	99.573	0.376