Detailed information    

insolico Bioinformatically predicted

Overview

Name   micB   Type   Regulator
Locus tag   ACLV65_RS04800 Genome accession   NZ_OZ217342
Coordinates   942984..944333 (+) Length   449 a.a.
NCBI ID   WP_050090938.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis B22     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 937984..949333
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV65_RS04775 (SMIB22_09310) coaB 938104..938793 (-) 690 WP_411864680.1 phosphopantothenate--cysteine ligase -
  ACLV65_RS04780 (SMIB22_09320) - 939026..940696 (+) 1671 WP_411864681.1 formate--tetrahydrofolate ligase -
  ACLV65_RS04785 (SMIB22_09330) - 940812..940970 (-) 159 WP_240149564.1 hypothetical protein -
  ACLV65_RS04790 (SMIB22_09340) mutY 941056..942231 (+) 1176 WP_411864682.1 A/G-specific adenine glycosylase -
  ACLV65_RS04795 (SMIB22_09350) micA 942287..942991 (+) 705 WP_411864683.1 response regulator YycF Regulator
  ACLV65_RS04800 (SMIB22_09360) micB 942984..944333 (+) 1350 WP_050090938.1 cell wall metabolism sensor histidine kinase VicK Regulator
  ACLV65_RS04805 (SMIB22_09370) vicX 944335..945144 (+) 810 WP_050302726.1 MBL fold metallo-hydrolase Regulator
  ACLV65_RS04810 (SMIB22_09380) relB 945235..945477 (+) 243 WP_172930976.1 type II toxin-antitoxin system RelB family antitoxin -
  ACLV65_RS04815 (SMIB22_09390) - 945479..945733 (+) 255 WP_033684234.1 type II toxin-antitoxin system RelE family toxin -
  ACLV65_RS04820 (SMIB22_09400) - 945809..947707 (+) 1899 WP_411864684.1 Eco57I restriction-modification methylase domain-containing protein -
  ACLV65_RS04825 (SMIB22_09410) - 947817..948767 (+) 951 WP_172922723.1 Abi family protein -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 51714.43 Da        Isoelectric Point: 4.9756

>NTDB_id=1170123 ACLV65_RS04800 WP_050090938.1 942984..944333(+) (micB) [Streptococcus mitis isolate S. mitis B22]
MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIRLKQINQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSE
VIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEEDYELRDLITQSPE
LLLDSQDINGEYLSLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALC
ETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIW
MEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLG
LSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=1170123 ACLV65_RS04800 WP_050090938.1 942984..944333(+) (micB) [Streptococcus mitis isolate S. mitis B22]
ATGCTTGATTTACTGAAACAAACCATTTTTACCAGAGATTTTATCTTTATCCTGATTTTGTTAGGTTTCATCCTTGTTGT
GACCCTCTTATTACTGGAAAATAGACGTGATAATATTCGGTTGAAACAAATCAATCAAAAGGTTAAAGATTTGATTGCAG
GAGATTATTCCAAGGTTCTTGATATGCAAGGTGGGTCTGAAATCACCAATATTACCAATAATTTGAATGACTTGTCGGAG
GTTATTCGTCTCACTCAGGAAAATCTAGAACAAGAGAGTAAGAGACTAAATAGTATTCTGTTTTATATGACAGATGGGGT
TCTTGCGACCAATCGTCGGGGGCAGATTATCATGATTAACGATACAGCCAAGAAGCAACTGGGGCTGGTTAAAGAAGATG
TTCTGAATAGAAGCATTTTAGAATTGCTCAAGATAGAAGAAGACTATGAATTGCGTGATTTGATTACCCAAAGTCCAGAA
TTGTTGCTAGATTCCCAAGACATCAATGGCGAATATCTGAGCCTTCGAGTTCGCTTTGCCTTGATTCGTCGAGAGTCTGG
CTTTATTTCAGGTTTGGTGGCTGTTTTGCATGATACGACGGAGCAGGAGAAGGAAGAACGCGAACGAAGACTCTTTGTTT
CCAACGTTAGCCATGAGTTACGGACTCCTCTGACTAGCGTAAAATCCTATCTTGAAGCCTTGGATGAGGGGGCTTTGTGT
GAAACTGTAGCACCAGACTTCATCAAGGTGTCTCTGGACGAAACCAACCGTATGATGCGCATGGTGACGGATCTCCTCCA
TCTCTCACGGATTGATAATGCGACCAGTCACCTAGATGTAGAATTGATAAACTTCACTGCCTTTATTACCTTTATCCTCA
ATCGTTTTGACAAGATGAAAGGACAGGAAAAGGAGAAAAAATATGAGTTGGTGAGAGATTATCCTATCAATTCTATCTGG
ATGGAAATTGATACAGATAAGATGACGCAGGTTGTCGACAATATTTTAAATAATGCCATTAAGTATTCGCCAGATGGGGG
TAAAATCACTGTCAGAATGAAGACAACTGAAGACCAGATGATTTTATCCATTTCTGACCACGGTTTGGGGATTCCTAAGC
AGGATTTACCACGTATCTTTGACCGTTTTTATCGTGTGGATCGTGCTAGAAGTCGTGCCCAAGGTGGTACAGGTTTAGGA
CTGTCTATTGCCAAAGAAATTATCAAACAACATAAGGGCTTTATTTGGGCCAAGAGTGAATACGGTAAGGGATCAACCTT
TACCATTGTGCTCCCTTATGATAAGGATGCAGTGAAAGAAGAAGTATGGGAGGATGAAGTAGAAGACTAG

Domains

Predicted by InterproScan.

PAS fold (PAS)

(98-198)

His Kinase A (phospho-acceptor) domain (HisKA)

(209-273)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(324-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micB Streptococcus pneumoniae Cp1015

99.109

100

0.991
  vicK Streptococcus mutans UA159

69.652

89.532

0.624

Multiple sequence alignment