Detailed information NTG1170047

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: ACLV7Q_RS06295
• Genome accession: NZ_OZ217341
• Coordinates: 1274136..1274786 (-)
• Length: 216 a.a.
• NCBI ID: WP_016398663.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis C22
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1269136..1279786

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7Q_RS06275 (SMIC22_12310)	-	1269740..1270921 (-)	1182	WP_218757803.1	hypothetical protein	-
ACLV7Q_RS06280 (SMIC22_12320)	-	1270925..1271512 (-)	588	WP_173252988.1	ATP-binding cassette domain-containing protein	-
ACLV7Q_RS06285	-	1271545..1271733 (-)	189	Protein_1191	hypothetical protein	-
ACLV7Q_RS06290 (SMIC22_12330)	comEC/celB	1271912..1274152 (-)	2241	WP_218757802.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
ACLV7Q_RS06295 (SMIC22_12340)	comEA/celA/cilE	1274136..1274786 (-)	651	WP_016398663.1	helix-hairpin-helix domain-containing protein	Machinery gene
ACLV7Q_RS06300 (SMIC22_12350)	-	1274854..1275423 (-)	570	WP_218757801.1	GNAT family N-acetyltransferase	-
ACLV7Q_RS06305 (SMIC22_12360)	-	1275530..1276534 (-)	1005	WP_218757800.1	PhoH family protein	-
ACLV7Q_RS06310 (SMIC22_12370)	-	1276620..1276835 (-)	216	WP_001232084.1	YozE family protein	-
ACLV7Q_RS06315 (SMIC22_12380)	cvfB	1276844..1277698 (-)	855	WP_001095445.1	RNA-binding virulence regulatory protein CvfB	-
ACLV7Q_RS06320 (SMIC22_12390)	frr	1277758..1278315 (-)	558	WP_001262225.1	ribosome recycling factor	-
ACLV7Q_RS06325 (SMIC22_12400)	pyrH	1278336..1279061 (-)	726	WP_173254341.1	UMP kinase	-

Sequence

Protein

• Length: 216 a.a.
• Molecular weight: 23203.52 Da
• Isoelectric Point: 5.5512

>NTDB_id=1170047 ACLV7Q_RS06295 WP_016398663.1 1274136..1274786(-) (comEA/celA/cilE) [Streptococcus mitis isolate S. mitis C22]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPTPQTPVKETNLQAEVAAISKDSSTEKDVKKEEKEEPVEQDLITVDVKG
AVKAPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAASQQAGPGTASSTSKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDYRETNGKFKSVDELKKVSGIGAKTIEKLKDYVTVD

Nucleotide

• Length: 651 bp

>NTDB_id=1170047 ACLV7Q_RS06295 WP_016398663.1 1274136..1274786(-) (comEA/celA/cilE) [Streptococcus mitis isolate S. mitis C22]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATTGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGAGGATT
TTTCCTGCTAAAGCCAACTCCACAAACACCTGTAAAAGAAACGAATTTACAGGCAGAAGTCGCAGCTATTTCCAAGGACT
CATCGACCGAAAAGGATGTGAAGAAGGAAGAAAAGGAAGAACCGGTTGAACAAGATCTAATCACAGTAGATGTAAAAGGC
GCTGTTAAAGCACCTGGAATTTATGATTTGCCGGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGATAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCCACTAAGGGAG
AAGAGGCAGCTAGTCAGCAGGCAGGTCCAGGGACGGCTTCTTCGACGAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAAGGACTGGGAGGAAAACGAGCTCAGGATATTATAGACTACCGTGAAACGAATGG
CAAATTCAAGTCGGTTGATGAACTTAAGAAGGTCTCTGGCATTGGTGCTAAAACGATAGAAAAGCTAAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

• Helix-hairpin-helix motif (HHH_3) (151-214)

• SLBB domain (SLBB) (76-126)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus mitis NCTC 12261	95.37	100	0.954
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	94.907	100	0.949
comEA/celA/cilE	Streptococcus pneumoniae D39	92.593	100	0.926
comEA/celA/cilE	Streptococcus mitis SK321	92.593	100	0.926
comEA/celA/cilE	Streptococcus pneumoniae R6	92.593	100	0.926
comEA/celA/cilE	Streptococcus pneumoniae Rx1	92.593	100	0.926
comEA	Lactococcus lactis subsp. cremoris KW2	40.889	100	0.426
comEA	Latilactobacillus sakei subsp. sakei 23K	35.193	100	0.38