Detailed information NTG1170046

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: ACLV7Q_RS06290
• Genome accession: NZ_OZ217341
• Coordinates: 1271912..1274152 (-)
• Length: 746 a.a.
• NCBI ID: WP_218757802.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis C22
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1266912..1279152

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7Q_RS06255 (SMIC22_12260)	-	1267820..1268200 (-)	381	WP_000157153.1	VOC family protein	-
ACLV7Q_RS06260 (SMIC22_12270)	rplT	1268259..1268618 (-)	360	WP_000124834.1	50S ribosomal protein L20	-
ACLV7Q_RS06265 (SMIC22_12280)	rpmI	1268670..1268870 (-)	201	WP_001125943.1	50S ribosomal protein L35	-
ACLV7Q_RS06270 (SMIC22_12290)	infC	1268903..1269433 (-)	531	WP_000848180.1	translation initiation factor IF-3	-
ACLV7Q_RS06275 (SMIC22_12310)	-	1269740..1270921 (-)	1182	WP_218757803.1	hypothetical protein	-
ACLV7Q_RS06280 (SMIC22_12320)	-	1270925..1271512 (-)	588	WP_173252988.1	ATP-binding cassette domain-containing protein	-
ACLV7Q_RS06285	-	1271545..1271733 (-)	189	Protein_1191	hypothetical protein	-
ACLV7Q_RS06290 (SMIC22_12330)	comEC/celB	1271912..1274152 (-)	2241	WP_218757802.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
ACLV7Q_RS06295 (SMIC22_12340)	comEA/celA/cilE	1274136..1274786 (-)	651	WP_016398663.1	helix-hairpin-helix domain-containing protein	Machinery gene
ACLV7Q_RS06300 (SMIC22_12350)	-	1274854..1275423 (-)	570	WP_218757801.1	GNAT family N-acetyltransferase	-
ACLV7Q_RS06305 (SMIC22_12360)	-	1275530..1276534 (-)	1005	WP_218757800.1	PhoH family protein	-
ACLV7Q_RS06310 (SMIC22_12370)	-	1276620..1276835 (-)	216	WP_001232084.1	YozE family protein	-
ACLV7Q_RS06315 (SMIC22_12380)	cvfB	1276844..1277698 (-)	855	WP_001095445.1	RNA-binding virulence regulatory protein CvfB	-
ACLV7Q_RS06320 (SMIC22_12390)	frr	1277758..1278315 (-)	558	WP_001262225.1	ribosome recycling factor	-
ACLV7Q_RS06325 (SMIC22_12400)	pyrH	1278336..1279061 (-)	726	WP_173254341.1	UMP kinase	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84372.69 Da
• Isoelectric Point: 9.3035

>NTDB_id=1170046 ACLV7Q_RS06290 WP_218757802.1 1271912..1274152(-) (comEC/celB) [Streptococcus mitis isolate S. mitis C22]
MLQWIKNFSIPLIYLSFLLLWLYYAIFSSSYLALLGFVFLLVCLFIQFPWKSAGRVLVICGVFGFWFLFQNWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKADGRIFQVYYKVQSEGEKEAFQALTALHDLELEGKLSEPEGQRNFGGFDYQAY
LKTQGIYQTLNIKKIQSLQKVGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMDGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLVQHGVKGLDNFALTVLVLFIV
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVARESLVISLGILPILSFYFAEFQPCSILLTFVFSFLFDLVFLPLLSI
LFALSFLYPVIQLNFIFEWLEGMIRLVSQVASRPLVFGQPNAWLLILLLISLALVYDLRKNIKMLTVLSLLITGLFFLTK
NPLENEITMLDAGQGESIFLRDVTGKTILIDVGGKAESSKKIEKWQEKTTTSNAQRSLIPYLKSRGVSKIDQLILTNTDK
EHIGDLLEVTKAFHVGEILVSKGSLKQKEFVAELQTAQTKVRSVTVGENLPIFGSQLEVLSPRKMGDGGHEDSLVLYGKL
LDKHFLFTENLEEKGEKDLLKHYPDLEVDVLKASQHGSKKSSSSAFLEKLKPELTLISVGKNNRTKLPHQETLTRLETIN
SKVYRTDQQGAIRFKGWNSWKIESVR

Nucleotide

• Length: 2241 bp

>NTDB_id=1170046 ACLV7Q_RS06290 WP_218757802.1 1271912..1274152(-) (comEC/celB) [Streptococcus mitis isolate S. mitis C22]
ATGTTACAGTGGATTAAGAATTTCTCTATTCCCCTAATTTACCTGAGTTTTCTGTTACTTTGGCTTTACTACGCCATTTT
CTCATCATCTTATCTCGCATTGCTAGGTTTTGTTTTTCTGCTAGTCTGTCTCTTTATTCAATTTCCTTGGAAATCAGCAG
GCAGAGTTCTAGTGATTTGTGGAGTCTTTGGCTTTTGGTTTCTGTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
TTGGCGGATTCTGTTGAAAGGGTACGGATTTTGCCTGATACTATTAAGGTTAATGGTGATAGTCTATCCTTTCGGGGCAA
GGCCGATGGCCGCATTTTTCAAGTCTATTATAAAGTCCAGTCTGAGGGGGAAAAAGAAGCCTTCCAAGCTTTAACAGCTC
TTCATGACTTGGAACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGATTTGACTATCAAGCCTAT
CTGAAAACTCAGGGAATTTACCAAACTCTCAATATCAAAAAAATCCAGTCACTTCAAAAGGTTGGCAGTTGGGATATAGG
TGAAAACTTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATCAAGACGCACTTTCCAGATCCTATGCGCAATTACATGA
CGGGGCTTCTATTAGGACATCTGGATACAGACTTTGAGGAGATGAATGAGCTTTATTCTAGTCTAGGAATTATCCACCTA
TTTGCCTTGTCGGGTATGCAGGTAGGCTTTTTCATGGATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCAGGTCTGACAGGATTTTCAGCCTCGGTCATTCGCAGTC
TTTTGCAAAAATTACTGGTCCAACATGGTGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTGACAGCAGGAGGAGTTTTGTCCTGTGCTTATGCTTTTATCTTGACCATGACCAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTGCTAGAGAAAGTCTAGTCATCTCCTTGGGTATATTGCCCATTCTGTCCTTCTATTTTGCGG
AATTTCAACCTTGCTCCATCCTTTTGACCTTTGTCTTTTCCTTTCTATTTGATTTGGTCTTCTTACCGCTCTTGTCTATC
TTATTTGCCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAATTTTATTTTTGAATGGTTGGAGGGGATGATTCGCTTGGT
ATCACAGGTGGCAAGTAGACCGCTTGTCTTTGGACAACCTAATGCGTGGCTTTTAATCTTGTTGTTAATTTCCTTGGCTT
TGGTCTATGATTTGAGGAAAAACATTAAAATGTTAACGGTATTGAGCTTATTGATTACAGGTCTCTTTTTCCTGACCAAG
AATCCACTAGAAAATGAAATCACCATGCTGGATGCGGGGCAAGGCGAAAGCATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTAGGCGGCAAGGCAGAGTCTAGTAAGAAAATAGAAAAATGGCAAGAAAAGACGACGACCAGCAATG
CCCAGAGAAGCTTGATACCCTATCTTAAAAGTCGAGGAGTGAGCAAGATTGACCAGCTGATTTTGACAAACACGGACAAG
GAGCATATTGGAGATTTGTTGGAGGTGACCAAGGCTTTCCATGTAGGCGAAATTTTAGTATCAAAAGGCAGTCTGAAACA
GAAGGAATTTGTGGCAGAACTACAGACTGCTCAAACCAAGGTGCGTAGTGTGACAGTAGGGGAGAACTTGCCAATTTTTG
GAAGTCAGTTAGAAGTCCTATCTCCAAGGAAAATGGGAGATGGAGGTCATGAAGATTCCCTGGTTCTTTATGGGAAACTC
TTGGATAAGCACTTCCTCTTCACAGAAAACTTGGAGGAGAAAGGAGAGAAGGACTTGTTGAAGCACTATCCTGACCTAGA
GGTGGATGTTTTGAAAGCTAGCCAACATGGCTCTAAAAAATCATCAAGTTCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAATAATCGAACGAAACTCCCCCATCAGGAAACTTTGACACGACTGGAAACGATCAAT
AGCAAAGTATATCGAACTGATCAGCAAGGAGCTATACGCTTTAAGGGTTGGAATAGTTGGAAGATTGAAAGCGTTCGATA
G

Domains

Predicted by InterproScan.

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-618)

• Competence protein (Competence) (216-458)

• Domain of unknown function (DUF4131) (DUF4131) (30-177)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis SK321	93.968	100	0.94
comEC/celB	Streptococcus mitis NCTC 12261	93.423	99.866	0.933
comEC/celB	Streptococcus pneumoniae Rx1	92.493	100	0.925
comEC/celB	Streptococcus pneumoniae D39	92.493	100	0.925
comEC/celB	Streptococcus pneumoniae R6	92.493	100	0.925
comEC/celB	Streptococcus pneumoniae TIGR4	92.493	100	0.925
comEC	Lactococcus lactis subsp. cremoris KW2	45.074	99.33	0.448