Detailed information NTG1169930

Bioinformatically predicted

Overview

• Name: comGE/cglE
• Type: Machinery gene
• Locus tag: ACLV7H_RS01075
• Genome accession: NZ_OZ217340
• Coordinates: 187085..187387 (+)
• Length: 100 a.a.
• NCBI ID: WP_045591925.1
• Uniprot ID: A0A0F2CXT2
• Organism: Streptococcus oralis isolate S. oralis A22
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 182085..192387

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7H_RS01045 (SORA22_02050)	nagA	182764..183915 (+)	1152	WP_411866133.1	N-acetylglucosamine-6-phosphate deacetylase	-
ACLV7H_RS01050 (SORA22_02060)	-	184067..184432 (+)	366	WP_000286396.1	DUF1033 family protein	-
ACLV7H_RS01055 (SORA22_02070)	comGA/cglA/cilD	184495..185436 (+)	942	WP_042768810.1	competence type IV pilus ATPase ComGA	Machinery gene
ACLV7H_RS01060 (SORA22_02080)	comGB/cglB	185384..186400 (+)	1017	WP_411867062.1	competence type IV pilus assembly protein ComGB	Machinery gene
ACLV7H_RS01065 (SORA22_02090)	comGC/cglC	186402..186725 (+)	324	WP_220107351.1	competence type IV pilus major pilin ComGC	Machinery gene
ACLV7H_RS01070 (SORA22_02100)	comGD/cglD	186688..187122 (+)	435	WP_411866134.1	competence type IV pilus minor pilin ComGD	Machinery gene
ACLV7H_RS01075 (SORA22_02110)	comGE/cglE	187085..187387 (+)	303	WP_045591925.1	competence type IV pilus minor pilin ComGE	Machinery gene
ACLV7H_RS01080 (SORA22_02120)	comGF/cglF	187350..187811 (+)	462	WP_045591923.1	competence type IV pilus minor pilin ComGF	Machinery gene
ACLV7H_RS01085 (SORA22_02130)	comGG/cglG	187789..188202 (+)	414	WP_411866135.1	competence type IV pilus minor pilin ComGG	Machinery gene
ACLV7H_RS01090 (SORA22_02140)	-	188235..188825 (+)	591	WP_411866136.1	class I SAM-dependent methyltransferase	-
ACLV7H_RS01095 (SORA22_02150)	comYH	188884..189837 (+)	954	WP_411866137.1	class I SAM-dependent methyltransferase	Machinery gene
ACLV7H_RS01100 (SORA22_02160)	-	189888..191078 (+)	1191	WP_411866138.1	acetate kinase	-
ACLV7H_RS01105 (SORA22_02170)	rnpA	191228..191599 (+)	372	WP_084848875.1	ribonuclease P protein component	-

Sequence

Protein

• Length: 100 a.a.
• Molecular weight: 11181.14 Da
• Isoelectric Point: 8.5690

>NTDB_id=1169930 ACLV7H_RS01075 WP_045591925.1 187085..187387(+) (comGE/cglE) [Streptococcus oralis isolate S. oralis A22]
MEKLNALRKQKIKAVILLEAVVALAVFASIATLLLGQIQKNRQEEAEILQKEEVLRVAKMALQTGRNQININGVEIQVFA
SEKGVEVYHGSEKLLDLKEQ

Nucleotide

• Length: 303 bp

>NTDB_id=1169930 ACLV7H_RS01075 WP_045591925.1 187085..187387(+) (comGE/cglE) [Streptococcus oralis isolate S. oralis A22]
ATGGAAAAATTAAACGCATTAAGGAAACAAAAGATTAAGGCAGTAATCTTACTAGAAGCAGTAGTTGCTCTAGCCGTGTT
TGCCAGCATTGCGACTCTTCTTTTGGGACAAATCCAGAAAAATAGGCAGGAAGAGGCAGAAATCTTGCAAAAAGAGGAGG
TATTACGAGTGGCTAAGATGGCCTTGCAGACAGGGCGAAATCAGATAAACATAAATGGAGTGGAGATTCAGGTGTTTGCT
AGTGAAAAAGGAGTGGAGGTCTACCATGGTTCAGAGAAGTTACTCGACCTTAAAGAGCAGTAA

Domains

Predicted by InterproScan.

• Type II secretory pathway pseudopilin (ComGE) (16-96)

3D structure

• AlphaFold DB: A0A0F2CXT2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comGE/cglE	Streptococcus mitis NCTC 12261	88.889	99	0.88
comGE/cglE	Streptococcus pneumoniae Rx1	88.889	99	0.88
comGE/cglE	Streptococcus pneumoniae D39	88.889	99	0.88
comGE/cglE	Streptococcus pneumoniae R6	88.889	99	0.88
comGE/cglE	Streptococcus pneumoniae TIGR4	88.889	99	0.88
comGE/cglE	Streptococcus mitis SK321	87.879	99	0.87
comYE	Streptococcus mutans UA140	42.391	92	0.39
comYE	Streptococcus mutans UA159	42.391	92	0.39