Detailed information NTG1160538

Bioinformatically predicted

Overview

• Name: covR
• Type: Regulator
• Locus tag: ACI6O7_RS07940
• Genome accession: NZ_OY725152
• Coordinates: 1637702..1638394 (-)
• Length: 230 a.a.
• NCBI ID: WP_003130756.1
• Uniprot ID: S6EZK2
• Organism: Lactococcus lactis strain IMDO WA12L8
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1632702..1643394

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACI6O7_RS07925 (LLWA12L8_FAMOGCFE_01595)	-	1634321..1634662 (-)	342	WP_010906046.1	P-II family nitrogen regulator	-
ACI6O7_RS07930 (LLWA12L8_FAMOGCFE_01596)	amt	1634794..1636035 (-)	1242	WP_404378210.1	ammonium transporter	-
ACI6O7_RS07935 (LLWA12L8_FAMOGCFE_01597)	covS	1636218..1637693 (-)	1476	WP_010906048.1	HAMP domain-containing histidine kinase	Regulator
ACI6O7_RS07940 (LLWA12L8_FAMOGCFE_01598)	covR	1637702..1638394 (-)	693	WP_003130756.1	response regulator transcription factor	Regulator
ACI6O7_RS07945 (LLWA12L8_FAMOGCFE_01599)	-	1638550..1639080 (-)	531	WP_058219348.1	DUF177 domain-containing protein	-
ACI6O7_RS07950 (LLWA12L8_FAMOGCFE_01600)	-	1639211..1639456 (-)	246	WP_003130760.1	type B 50S ribosomal protein L31	-
ACI6O7_RS07955 (LLWA12L8_FAMOGCFE_01601)	-	1639612..1640076 (-)	465	WP_404378211.1	hypothetical protein	-
ACI6O7_RS07960 (LLWA12L8_FAMOGCFE_01602)	-	1640158..1640520 (-)	363	WP_010906050.1	TIGR02328 family protein	-
ACI6O7_RS07965 (LLWA12L8_FAMOGCFE_01603)	-	1641006..1641536 (-)	531	WP_404378212.1	CHAP domain-containing protein	-
ACI6O7_RS07970 (LLWA12L8_FAMOGCFE_01604)	-	1641598..1641738 (-)	141	WP_259390987.1	hypothetical protein	-
ACI6O7_RS07975 (LLWA12L8_FAMOGCFE_01605)	-	1641738..1642433 (-)	696	WP_404378213.1	metallophosphoesterase	-

Sequence

Protein

• Length: 230 a.a.
• Molecular weight: 26684.36 Da
• Isoelectric Point: 5.1273

>NTDB_id=1160538 ACI6O7_RS07940 WP_003130756.1 1637702..1638394(-) (covR) [Lactococcus lactis strain IMDO WA12L8]
MTSKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM
TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE
YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

• Length: 693 bp

>NTDB_id=1160538 ACI6O7_RS07940 WP_003130756.1 1637702..1638394(-) (covR) [Lactococcus lactis strain IMDO WA12L8]
ATGACTTCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCGCGATTCGTCTCATTAGAATTAGAACATGAAGG
CTATGCGACTGAGATTAAAGATAATGGTCGTTCTGGTCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG
ATTTGATGCTTCCTGAACTTGACGGTTTTGAGGTAGCCCGTCGTTTACGAAAAGAAAAAGATACACCAATCATTATGATG
ACGGCACGTGATTCAACGATGGACCGTGTTGCTGGTCTTGATATTGGGGCTGATGATTATATCACTAAACCTTTTGCGAT
TGAGGAACTTTTGGCGCGTGTTCGTGCTTTCTTCCGTCGTGAAGAGCACGGTCATGCCGTTGAACGTGCTGAAAATACTT
CTTTCCGTGATCTTGTGATTGACAAAACGAATCGCACCGTTCATCGTGGTAAAAAAGTAATTGATTTAACACGTCGTGAG
TATGACCTCCTTTTGACATTGATGCAAAATGTTGGCGATGTTGTGACTCGTGAACATTTAGTTTCACAAGTTTGGGGATA
TGAAGAAGGAACAGAAACAAATGTTGTGGATGTTTATATTCGTTATCTTAGAAATAAAATTGATGTTGAAGGTCAAGATA
GCTATATTCAAACTGTTCGTGGCTTAGGTTATGTAATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (6-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-226)

3D structure

• AlphaFold DB: S6EZK2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	100	100	1
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361