Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   AD178_RS02855 Genome accession   NZ_OX244288
Coordinates   550391..552544 (-) Length   717 a.a.
NCBI ID   WP_000205170.1    Uniprot ID   G3ECC8
Organism   Streptococcus pneumoniae strain PT8105 isolate 2RLC4     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 545391..557544
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AD178_RS02825 (SAMEA1463109_00566) - 545726..546055 (-) 330 WP_000132576.1 hypothetical protein -
  AD178_RS02830 (SAMEA1463109_00567) - 546331..546669 (+) 339 WP_000682121.1 LytTR family DNA-binding domain-containing protein -
  AD178_RS02835 (SAMEA1463109_00568) comE/blpR 546674..547411 (+) 738 WP_001219145.1 response regulator transcription factor Regulator
  AD178_RS02840 (SAMEA1463109_00569) - 547425..548765 (+) 1341 WP_001017620.1 sensor histidine kinase -
  AD178_RS02845 (SAMEA1463109_00570) blpC 548807..548962 (-) 156 WP_000358817.1 quorum-sensing system pheromone BlpC -
  AD178_RS02850 (SAMEA1463109_00571) - 549019..550380 (-) 1362 WP_001069073.1 bacteriocin secretion accessory protein -
  AD178_RS02855 (SAMEA1463109_00572) comA/nlmT 550391..552544 (-) 2154 WP_000205170.1 peptide cleavage/export ABC transporter BlpA Regulator
  AD178_RS02860 (SAMEA1463109_00573) - 552825..553028 (+) 204 WP_001093272.1 bacteriocin class II family protein -
  AD178_RS02865 (SAMEA1463109_00574) - 553346..553549 (+) 204 WP_000411016.1 hypothetical protein -
  AD178_RS02870 - 554552..555356 (+) 805 Protein_566 IS5 family transposase -
  AD178_RS02875 (SAMEA1463109_00578) blpM 555506..555760 (+) 255 WP_000379879.1 two-peptide bacteriocin subunit BlpM -
  AD178_RS02880 (SAMEA1463109_00579) blpN 555776..555979 (+) 204 WP_001099492.1 two-peptide bacteriocin subunit BlpN -
  AD178_RS02885 (SAMEA1463109_00580) cipB 556223..556372 (+) 150 WP_001818346.1 bacteriocin-like peptide BlpO Regulator
  AD178_RS02890 - 556476..556595 (+) 120 WP_000346296.1 PncF family bacteriocin immunity protein -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80795.81 Da        Isoelectric Point: 7.6798

>NTDB_id=1154310 AD178_RS02855 WP_000205170.1 550391..552544(-) (comA/nlmT) [Streptococcus pneumoniae strain PT8105 isolate 2RLC4]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLVIGDPDPSVKITKMSKERFFSEWTGVAIFLAPKPSYQPHKDKKNGLLSFLPL
IFKQKSLIAYIVLSSLLVTIINIGGSYYLQGILDEYIPNQMKSTLGIISVGLVITYILQQVMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANSIIDALASTILSLFLDVSILILVGGVLLAQNPNLFLLSLISIPIYMF
IIFSFMKPFEKMNHDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQNIDSEFVDYLEKSFKLSKYSILQTSLKQGTKL
VLNILILWFGAQLVMSSKISIGQLITFNTLLSYFTTPMENIINLQTKLQSAKVANNRLNEVYLVESEFQVQENPVHSHFL
MGDIEFDDLSYKYGFGRDTLTDINLTIKQGDKVSLVGVSGSGKTTLAKMIVNFFEPYKGHISINHQDIKNIDKKVLRRHI
NYLPQQAYIFNGSILENLTLGGNHMISQEDILRACELAEIRQDIERMPMGYQTQLSDGAGLSGGQKQRIALARALLTKSP
VLILDEATSGLDVLTEKKVIDNLMSLTDKTILFVAHRLSIAERTNRVIVLDQGKIIEVGSHQELMQAQGFYHHLFNK

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=1154310 AD178_RS02855 WP_000205170.1 550391..552544(-) (comA/nlmT) [Streptococcus pneumoniae strain PT8105 isolate 2RLC4]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGGCCTGTTCAAGCAGATAAAACTCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGGTTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTCTGAATGGACTGGAG
TAGCTATTTTTCTAGCTCCCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCTTCCTTCCTCTG
ATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTTCTTA
TTATCTCCAAGGAATCTTAGATGAATACATCCCAAATCAGATGAAATCAACTTTAGGAATCATCTCAGTTGGTCTGGTTA
TCACCTATATCCTCCAACAAGTCATGAGCTTCTCCAGAGATTATCTCCTAACCGTTCTGAGCCAGAGATTAAGCATTGAT
GTGATTTTATCCTATATTCGCCATATTTTTGAACTTCCCATGTCTTTCTTTGCGACACGTCGTACAGGAGAAATCATTTC
ACGGTTCACAGATGCTAACTCTATTATAGATGCCTTGGCTTCTACCATTCTTTCTCTTTTCCTGGATGTTTCTATTCTGA
TTCTTGTAGGGGGCGTCTTACTGGCACAAAACCCTAATCTCTTCCTTCTTTCTCTTATTTCTATTCCTATATACATGTTC
ATCATCTTTTCTTTTATGAAGCCTTTCGAAAAAATGAACCATGATGTCATGCAAAGTAATTCTATGGTTAGCTCTGCCAT
TATCGAAGATATCAACGGGATTGAAACTATAAAGTCGCTCACGAGTGAAGAAAATCGCTATCAAAATATAGACAGCGAAT
TTGTAGATTATTTGGAAAAATCCTTTAAGCTCAGTAAATATTCTATTTTACAAACAAGTTTAAAGCAGGGAACAAAATTA
GTTCTGAATATCCTTATCCTATGGTTTGGCGCTCAATTAGTCATGTCGAGTAAAATTTCTATCGGTCAGCTGATTACCTT
TAACACACTTCTTTCTTACTTTACAACTCCTATGGAAAATATTATCAACCTCCAAACCAAACTCCAATCTGCGAAGGTTG
CTAATAACCGTTTGAACGAAGTCTATCTAGTCGAATCTGAATTTCAAGTTCAAGAAAACCCTGTTCATTCACATTTTTTG
ATGGGCGATATTGAATTTGATGACCTTTCTTATAAGTATGGTTTTGGACGAGATACCTTAACAGATATTAATCTCACGAT
TAAACAAGGAGATAAGGTTAGCCTAGTTGGAGTTAGTGGTTCTGGTAAAACAACTTTAGCCAAAATGATTGTCAATTTCT
TTGAACCCTACAAAGGACATATTTCCATCAATCATCAGGATATTAAAAACATTGATAAAAAAGTCTTGCGCCGTCATATT
AATTACCTACCACAACAAGCCTATATCTTTAATGGCTCTATCTTGGAAAACTTAACTTTGGGCGGTAATCATATGATTAG
CCAAGAAGATATTCTAAGAGCTTGTGAATTAGCTGAAATTCGTCAAGACATTGAAAGAATGCCTATGGGCTATCAAACTC
AGCTCTCTGATGGAGCTGGTCTATCAGGAGGACAAAAGCAACGAATAGCCCTCGCTCGTGCTCTTTTAACTAAATCTCCT
GTTTTAATACTAGACGAAGCTACTAGCGGTCTTGATGTCTTGACTGAGAAAAAGGTTATAGATAATCTTATGTCTCTAAC
TGATAAAACCATTCTCTTTGTAGCCCATCGTCTCAGTATAGCCGAACGAACCAACCGTGTCATTGTTCTTGACCAGGGGA
AAATCATTGAAGTTGGTAGTCACCAAGAGTTAATGCAGGCGCAAGGTTTCTACCATCATCTATTCAATAAATAA

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter (ABC_tran)

(500-649)

ABC transporter transmembrane region (ABC_membrane)

(169-438)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB G3ECC8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

71.888

99.721

0.717
  comA Streptococcus mitis NCTC 12261

66.62

99.442

0.662
  comA Streptococcus pneumoniae Rx1

66.059

99.442

0.657
  comA Streptococcus pneumoniae R6

66.059

99.442

0.657
  comA Streptococcus pneumoniae D39

66.059

99.442

0.657
  comA Streptococcus mitis SK321

66.059

99.442

0.657
  comA Streptococcus gordonii str. Challis substr. CH1

65.32

100

0.654
  comA Streptococcus pneumoniae TIGR4

65.778

99.442

0.654

Multiple sequence alignment