Detailed information NTG1154309

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: AD178_RS02835
• Genome accession: NZ_OX244288
• Coordinates: 546674..547411 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219145.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain PT8105 isolate 2RLC4
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 541674..552411

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AD178_RS02800 (SAMEA1463109_00561)	-	542712..542951 (-)	240	WP_001813906.1	hypothetical protein	-
AD178_RS02805 (SAMEA1463109_00562)	-	543113..543400 (-)	288	WP_000777760.1	hypothetical protein	-
AD178_RS02810 (SAMEA1463109_00563)	-	543410..543820 (-)	411	WP_001278301.1	HIT family protein	-
AD178_RS02815 (SAMEA1463109_00564)	pptA	543888..544619 (+)	732	WP_000889917.1	ABC transporter ATP-binding protein	Regulator
AD178_RS02820 (SAMEA1463109_00565)	-	544616..545665 (+)	1050	WP_000653752.1	ABC transporter permease	-
AD178_RS02825 (SAMEA1463109_00566)	-	545726..546055 (-)	330	WP_000132576.1	hypothetical protein	-
AD178_RS02830 (SAMEA1463109_00567)	-	546331..546669 (+)	339	WP_000682121.1	LytTR family DNA-binding domain-containing protein	-
AD178_RS02835 (SAMEA1463109_00568)	comE/blpR	546674..547411 (+)	738	WP_001219145.1	response regulator transcription factor	Regulator
AD178_RS02840 (SAMEA1463109_00569)	-	547425..548765 (+)	1341	WP_001017620.1	sensor histidine kinase	-
AD178_RS02845 (SAMEA1463109_00570)	blpC	548807..548962 (-)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
AD178_RS02850 (SAMEA1463109_00571)	-	549019..550380 (-)	1362	WP_001069073.1	bacteriocin secretion accessory protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28798.90 Da
• Isoelectric Point: 6.0454

>NTDB_id=1154309 AD178_RS02835 WP_001219145.1 546674..547411(+) (comE/blpR) [Streptococcus pneumoniae strain PT8105 isolate 2RLC4]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=1154309 AD178_RS02835 WP_001219145.1 546674..547411(+) (comE/blpR) [Streptococcus pneumoniae strain PT8105 isolate 2RLC4]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCCCAGCTCTTTTGAGGTATTTGGCAAGCCAGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCCTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGAATCGAGACAGCTCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGTTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-241)

• Response regulator receiver domain (Response_reg) (3-122)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.882	96.735	0.424
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384
comE	Streptococcus infantis strain Atu-4	36.179	100	0.363