Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA/celA/cilE   Type   Machinery gene
Locus tag   MMH06_RS10505 Genome accession   NZ_OV904788
Coordinates   2048684..2049334 (-) Length   216 a.a.
NCBI ID   WP_000387328.1    Uniprot ID   A0A4N9N7Z7
Organism   Streptococcus pneumoniae strain RMV7 isolate RMV7domi     
Function   dsDNA binding to the cell surface (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 2043684..2054334
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MMH06_RS10485 (IONPJBJN_02089) - 2044289..2045470 (-) 1182 WP_000655951.1 membrane protein -
  MMH06_RS10490 (IONPJBJN_02090) - 2045474..2046061 (-) 588 WP_000939884.1 ABC transporter ATP-binding protein -
  MMH06_RS10495 (IONPJBJN_02091) - 2046094..2046318 (-) 225 WP_000583432.1 hypothetical protein -
  MMH06_RS10500 (IONPJBJN_02092) comEC/celB 2046460..2048700 (-) 2241 WP_000942392.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  MMH06_RS10505 (IONPJBJN_02093) comEA/celA/cilE 2048684..2049334 (-) 651 WP_000387328.1 ComEA family DNA-binding protein Machinery gene
  MMH06_RS10510 (IONPJBJN_02094) - 2049402..2049971 (-) 570 WP_000443775.1 GNAT family N-acetyltransferase -
  MMH06_RS10515 ald 2050148..2051259 (+) 1112 Protein_2047 alanine dehydrogenase -
  MMH06_RS10520 (IONPJBJN_02097) - 2051560..2051886 (-) 327 Protein_2048 TfoX/Sxy family protein -
  MMH06_RS10525 (IONPJBJN_02098) - 2051889..2052389 (-) 501 WP_000566986.1 GNAT family N-acetyltransferase -
  MMH06_RS10530 (IONPJBJN_02099) - 2052582..2053550 (-) 969 WP_000658198.1 PhoH family protein -
  MMH06_RS10535 (IONPJBJN_02100) - 2053636..2053851 (-) 216 WP_001232081.1 YozE family protein -

Sequence

Protein


Download         Length: 216 a.a.        Molecular weight: 23230.59 Da        Isoelectric Point: 5.0667

>NTDB_id=1152133 MMH06_RS10505 WP_000387328.1 2048684..2049334(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain RMV7 isolate RMV7domi]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDLVSEEEVNKEEKEEPLEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGLGTASSISKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD

Nucleotide


Download         Length: 651 bp        

>NTDB_id=1152133 MMH06_RS10505 WP_000387328.1 2048684..2049334(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain RMV7 isolate RMV7domi]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGAGGATT
TTTCCTGCTAAAACCAGCTCCACAAACACCTGTCAAAGAGACGAATTTGCAGGCTGAAGTCGCAGCTGTTTCCAAGGATT
TGGTATCCGAAGAGGAAGTGAACAAGGAAGAAAAGGAAGAACCCCTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGCCAACAGACTGGTTTGGGGACAGCTTCTTCAATAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGGCAAAACAATAGAAAAGCTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

SLBB domain (SLBB)

(76-126)

Helix-hairpin-helix motif (HHH_3)

(151-214)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4N9N7Z7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA/celA/cilE Streptococcus pneumoniae Rx1

99.537

100

0.995
  comEA/celA/cilE Streptococcus pneumoniae D39

99.537

100

0.995
  comEA/celA/cilE Streptococcus pneumoniae R6

99.537

100

0.995
  comEA/celA/cilE Streptococcus pneumoniae TIGR4

96.759

100

0.968
  comEA/celA/cilE Streptococcus mitis NCTC 12261

95.833

100

0.958
  comEA/celA/cilE Streptococcus mitis SK321

89.815

100

0.898
  comEA Lactococcus lactis subsp. cremoris KW2

43.172

100

0.454
  comEA Bacillus subtilis subsp. subtilis str. 168

41.579

87.963

0.366

Multiple sequence alignment