Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   CKV83_RS09210 Genome accession   NZ_LT906439
Coordinates   1974891..1976105 (+) Length   404 a.a.
NCBI ID   WP_018373568.1    Uniprot ID   A0A239T0A1
Organism   Streptococcus merionis strain NCTC13788     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1969891..1981105
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CKV83_RS09180 (SAMEA4412692_01831) - 1969904..1972510 (+) 2607 WP_018373572.1 YfhO family protein -
  CKV83_RS09200 (SAMEA4412692_01835) - 1973576..1974286 (-) 711 WP_018373570.1 YoaK family protein -
  CKV83_RS09205 (SAMEA4412692_01836) rlmH 1974334..1974813 (+) 480 WP_018373569.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  CKV83_RS09210 (SAMEA4412692_01837) htrA 1974891..1976105 (+) 1215 WP_018373568.1 S1C family serine protease Regulator
  CKV83_RS09215 (SAMEA4412692_01838) spo0J 1976181..1976945 (+) 765 WP_018373567.1 ParB/RepB/Spo0J family partition protein Regulator
  CKV83_RS09220 (SAMEA4412692_01839) dnaA 1977151..1978530 (+) 1380 WP_018373566.1 chromosomal replication initiator protein DnaA -
  CKV83_RS09225 (SAMEA4412692_01840) dnaN 1978681..1979817 (+) 1137 WP_018373565.1 DNA polymerase III subunit beta -
  CKV83_RS09230 (SAMEA4412692_01841) - 1979895..1980092 (+) 198 WP_018373564.1 DUF951 domain-containing protein -
  CKV83_RS09235 (SAMEA4412692_01842) - 1980224..1980613 (+) 390 WP_018373563.1 helix-turn-helix domain-containing protein -

Sequence

Protein


Download         Length: 404 a.a.        Molecular weight: 41749.58 Da        Isoelectric Point: 4.7841

>NTDB_id=1147148 CKV83_RS09210 WP_018373568.1 1974891..1976105(+) (htrA) [Streptococcus merionis strain NCTC13788]
MKNSMKKLLHILLILLVGFIGGTLGVVTMQKFGNSSAVTNSTTTTSTKNGTTTSNVTYNNTTSVSEAVDKVKNAVVSVIN
YQTSNNNSRNPYSIFGDNNNSGELAVAGEGSGVIYKKEGNSAYLVTNTHVVAGAEQIEIKLADGNTVKGTLVGSDTYSDI
SVVKIDASVVTTVAEFGNSDSLNVGEVAIAIGSPLGTEYANSVTQGIVSSLSRTVTSKAEDGQTISTNAIQTDAAINPGN
SGGPLINIQGQVIGITSSKITSSSASLSSSVSVEGMGFAIPANDAVAIIAQLEKNGKVERPALGIQMASLSNLSATDIAR
LNVPKDLTAGIVVVSVHSGLSADGRLKAYDIITKIDGKTIESSSDLQSALYSKNIGDTITVTFYRDGKEQTTDIQLSSST
DDLQ

Nucleotide


Download         Length: 1215 bp        

>NTDB_id=1147148 CKV83_RS09210 WP_018373568.1 1974891..1976105(+) (htrA) [Streptococcus merionis strain NCTC13788]
ATGAAAAATAGTATGAAAAAATTATTACATATTTTATTGATTCTACTTGTAGGATTTATCGGTGGTACTTTAGGCGTAGT
AACCATGCAAAAATTTGGAAATTCCTCTGCGGTTACTAACAGCACAACAACTACATCAACAAAGAATGGAACTACAACTA
GTAATGTCACCTATAACAATACAACCTCTGTCTCAGAAGCTGTTGATAAGGTAAAAAATGCCGTTGTTTCTGTCATCAAT
TATCAAACCTCTAATAACAATTCAAGGAATCCTTACAGTATTTTTGGTGATAATAACAATAGTGGTGAATTAGCTGTTGC
TGGTGAGGGATCTGGTGTTATTTACAAAAAAGAAGGGAACTCTGCTTACCTAGTTACCAATACTCACGTCGTTGCTGGCG
CTGAACAAATTGAAATCAAATTAGCTGATGGTAACACTGTAAAAGGAACTCTAGTTGGATCAGACACCTATTCTGATATT
TCTGTCGTTAAAATTGACGCTTCTGTAGTCACTACTGTTGCTGAATTTGGAAACTCTGACAGCCTTAATGTAGGTGAAGT
AGCGATCGCTATCGGTAGCCCACTAGGAACCGAATATGCTAACTCAGTCACCCAAGGTATCGTGTCTAGTCTTAGCCGAA
CTGTCACATCCAAAGCTGAAGATGGTCAAACTATCTCAACTAATGCTATCCAAACAGATGCTGCCATCAACCCTGGTAAT
TCAGGTGGACCACTGATTAACATCCAAGGTCAAGTCATCGGTATCACTTCAAGTAAGATTACATCTAGCTCAGCATCACT
TTCTTCCAGTGTTTCCGTTGAAGGTATGGGATTTGCCATTCCAGCAAACGATGCTGTTGCTATCATAGCGCAATTAGAAA
AAAATGGTAAGGTTGAACGCCCTGCTTTAGGCATCCAAATGGCCAGCCTCAGTAACTTATCTGCTACAGATATTGCACGT
CTAAATGTCCCTAAAGACTTAACTGCTGGTATCGTTGTTGTTTCTGTTCACTCTGGTCTTTCTGCTGACGGTCGTCTTAA
AGCTTACGATATCATCACTAAAATTGATGGCAAAACGATTGAATCAAGCAGTGATTTGCAAAGTGCCCTTTATTCTAAGA
ACATTGGAGACACTATTACAGTGACTTTCTATCGAGATGGAAAAGAACAAACAACAGATATTCAATTGAGCAGCTCAACA
GACGATTTACAATAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(301-396)

Peptidase family M50 (Peptidase_M50)

(186-399)

Trypsin-like peptidase domain (Trypsin_2)

(110-255)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A239T0A1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

61.029

100

0.616
  htrA Streptococcus mutans UA159

59.102

99.257

0.587
  htrA Streptococcus mitis NCTC 12261

56.296

100

0.564
  htrA Streptococcus pneumoniae TIGR4

56.049

100

0.562
  htrA Streptococcus pneumoniae D39

56.049

100

0.562
  htrA Streptococcus pneumoniae Rx1

56.049

100

0.562
  htrA Streptococcus pneumoniae R6

56.049

100

0.562

Multiple sequence alignment