Detailed information NTG1146178

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: BQ8897_RS10135
• Genome accession: NZ_LT714196
• Coordinates: 1929008..1929760 (-)
• Length: 250 a.a.
• NCBI ID: WP_001019938.1
• Uniprot ID: -
• Organism: Streptococcus agalactiae isolate BM110
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1924008..1934760

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BQ8897_RS10105	-	1924708..1924890 (+)	183	WP_001869123.1	hypothetical protein	-
BQ8897_RS10110 (BQ8897_BM110_01988)	-	1924885..1926039 (-)	1155	WP_000623424.1	ABC transporter permease subunit	-
BQ8897_RS10115 (BQ8897_BM110_01989)	-	1926045..1926893 (-)	849	WP_000926585.1	ABC transporter ATP-binding protein	-
BQ8897_RS10120 (BQ8897_BM110_01990)	-	1926962..1927135 (-)	174	WP_000683602.1	hypothetical protein	-
BQ8897_RS10125 (BQ8897_BM110_01991)	-	1927424..1927588 (+)	165	Protein_1898	cysteine peptidase family C39 domain-containing protein	-
BQ8897_RS10130 (BQ8897_BM110_01992)	-	1927677..1929011 (-)	1335	WP_086874326.1	sensor histidine kinase	-
BQ8897_RS10135 (BQ8897_BM110_01993)	comE/blpR	1929008..1929760 (-)	753	WP_001019938.1	response regulator transcription factor	Regulator
BQ8897_RS10145 (BQ8897_BM110_01994)	-	1929976..1930791 (-)	816	WP_001029871.1	endonuclease/exonuclease/phosphatase family protein	-
BQ8897_RS10150 (BQ8897_BM110_01995)	-	1930845..1933028 (-)	2184	WP_000795059.1	PTS transporter subunit IIBC	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29451.04 Da
• Isoelectric Point: 8.4441

>NTDB_id=1146178 BQ8897_RS10135 WP_001019938.1 1929008..1929760(-) (comE/blpR) [Streptococcus agalactiae isolate BM110]
MNIFILEDNFIQQARLERIIEEVKIRRSIHSKMVNTFEKPVQLLESICEKGMHNLYFLDIEIKNDEQRGLEVAKQIRQID
PYAQIVFVTTHSELMPLTFRYQVSALDYIDKGLSQEAFSRRIEDVLLYANNACSKNLLEDSFYFKSRYSQVQVPFNDILY
IETSLRSHRVVLYTAKDRMEFTATLGDILKQEPRLFQCHRSFLVNPLNIFKVDRSNKLIYLKNGSNCLISRNKIKDIMVV
IEENQRGRGI

Nucleotide

• Length: 753 bp

>NTDB_id=1146178 BQ8897_RS10135 WP_001019938.1 1929008..1929760(-) (comE/blpR) [Streptococcus agalactiae isolate BM110]
GTGAATATTTTTATTTTAGAGGATAATTTTATTCAACAGGCACGTTTAGAGAGAATAATTGAGGAAGTTAAAATTAGGAG
AAGTATACACAGTAAAATGGTAAATACCTTTGAAAAACCAGTTCAATTATTGGAATCAATCTGTGAAAAAGGTATGCATA
ATTTATATTTCTTAGACATTGAAATAAAAAATGATGAGCAGAGGGGCTTAGAGGTCGCAAAACAAATTAGACAAATTGAT
CCTTATGCTCAGATTGTTTTTGTTACAACTCATTCGGAATTAATGCCTTTAACCTTTCGTTATCAGGTATCAGCTTTAGA
CTATATCGATAAAGGACTTTCACAGGAAGCATTTAGCAGAAGGATTGAAGACGTTTTACTATATGCTAATAATGCTTGCA
GTAAAAACTTACTAGAAGATTCTTTTTATTTTAAATCACGCTATAGTCAAGTACAAGTACCTTTTAACGATATCCTTTAT
ATAGAAACGTCATTAAGGTCACATAGAGTTGTCCTTTATACTGCAAAAGACAGAATGGAATTCACAGCCACTTTGGGGGA
TATTTTAAAACAAGAACCTAGGCTCTTTCAATGTCATCGCTCTTTTTTAGTAAATCCCTTGAATATTTTTAAAGTGGATA
GGTCAAATAAACTAATCTATTTAAAAAATGGTTCGAATTGTTTGATTTCTCGTAATAAAATAAAAGATATTATGGTAGTA
ATAGAGGAAAATCAAAGAGGTAGAGGAATATGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-238)

• Response regulator receiver domain (Response_reg) (3-122)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	52.61	99.6	0.524
comE/comE1	Streptococcus equinus JB1	42.678	95.6	0.408
comE	Streptococcus pneumoniae D39	38.866	98.8	0.384
comE	Streptococcus pneumoniae R6	38.866	98.8	0.384
comE	Streptococcus pneumoniae TIGR4	38.866	98.8	0.384
comE	Streptococcus mitis SK321	38.866	98.8	0.384
comE	Streptococcus mitis NCTC 12261	38.866	98.8	0.384
comE	Streptococcus pneumoniae Rx1	38.866	98.8	0.384
comE	Streptococcus infantis strain Atu-4	36.8	100	0.368