Detailed information NTG1145999

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: BUC38_RS05225
• Genome accession: NZ_LT671674
• Coordinates: 1053967..1054638 (+)
• Length: 223 a.a.
• NCBI ID: WP_029176020.1
• Uniprot ID: A0A116M8K0
• Organism: Streptococcus suis strain LS9N
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1048967..1059638

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BUC38_RS05195	pstC	1049046..1049963 (+)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-
BUC38_RS05200	pstA	1049953..1050840 (+)	888	WP_014635996.1	phosphate ABC transporter permease PstA	-
BUC38_RS05205	pstB	1050865..1051668 (+)	804	WP_029185151.1	phosphate ABC transporter ATP-binding protein PstB	-
BUC38_RS05210	pstB	1051680..1052438 (+)	759	WP_044673059.1	phosphate ABC transporter ATP-binding protein PstB	-
BUC38_RS05215	phoU	1052467..1053123 (+)	657	WP_002940865.1	phosphate signaling complex protein PhoU	-
BUC38_RS05220	-	1053273..1053821 (+)	549	WP_032511937.1	hypothetical protein	-
BUC38_RS05225	ciaR	1053967..1054638 (+)	672	WP_029176020.1	response regulator transcription factor	Regulator
BUC38_RS05230	ciaH	1054631..1056010 (+)	1380	WP_044690760.1	HAMP domain-containing sensor histidine kinase	Regulator
BUC38_RS05235	-	1056110..1057339 (+)	1230	WP_044690763.1	transglutaminase domain-containing protein	-
BUC38_RS05240	rpsT	1057554..1057802 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
BUC38_RS05245	coaA	1057861..1058781 (-)	921	WP_002940857.1	type I pantothenate kinase	-
BUC38_RS05250	-	1058890..1059480 (+)	591	WP_024376492.1	class I SAM-dependent methyltransferase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25277.89 Da
• Isoelectric Point: 4.2183

>NTDB_id=1145999 BUC38_RS05225 WP_029176020.1 1053967..1054638(+) (ciaR) [Streptococcus suis strain LS9N]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGIYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDMTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=1145999 BUC38_RS05225 WP_029176020.1 1053967..1054638(+) (ciaR) [Streptococcus suis strain LS9N]
ATGATTAAGATTTTGTTAGTAGAAGACGATTTAAGCCTATCCAATTCAGTTTTTGACTTCCTAGATGATTTTGCAGATGT
CATGCAAGTTTTTGATGGAGAAGAAGGAATCTATGAAGCGGAAACTGGTGTGTACGACTTAATTTTATTAGATTTAATGT
TACCTGAAAAAGACGGCTTTCAAGTCTTGAAAGAGTTACGTGAAAAAGGTGTTACAACTCCTGTCTTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGCGCTGATGACTACTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTGACTTATGGGGACATGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTAGTCTAC
TTCTTGCAAAATCAAAATGTTATCTTACCCAAAACTCAAATTTTTGATAGAATTTGGGGATTTGACAGTGATACAACAAT
CTCTGTTGTAGAGGTATATGTTTCAAAAATCCGTAAAAAATTGAAGGGGACAACATTTGGAGAAAATTTACAAACTCTCC
GCAGTGTTGGATATATCTTGAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: A0A116M8K0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368