Detailed information NTG1142995

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: DQL00_RS12405
• Genome accession: NZ_LS483523
• Coordinates: 2114292..2114879 (+)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain 4041STDY6836169
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 2109292..2119879

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL00_RS11220	-	2109548..2109667 (-)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
DQL00_RS11225	cipB	2109771..2109920 (-)	150	WP_001820573.1	bacteriocin-like peptide BlpO	Regulator
DQL00_RS11235	blpN	2110164..2110367 (-)	204	WP_001099492.1	two-peptide bacteriocin subunit BlpN	-
DQL00_RS11240	blpM	2110383..2110637 (-)	255	WP_000379877.1	two-peptide bacteriocin subunit BlpM	-
DQL00_RS11250	-	2111794..2112198 (-)	405	WP_000846943.1	hypothetical protein	-
DQL00_RS11255	-	2112195..2112359 (-)	165	WP_000727118.1	hypothetical protein	-
DQL00_RS11260	-	2112656..2112775 (-)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
DQL00_RS11265	blpU	2112778..2113008 (-)	231	WP_000379967.1	bacteriocin-like peptide BlpU	-
DQL00_RS11270	blpJ	2113077..2113346 (-)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
DQL00_RS11280	blpI	2113813..2114010 (-)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
DQL00_RS12405	comA/nlmT	2114292..2114879 (+)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
DQL00_RS11285	comA/nlmT	2114806..2116449 (+)	1644	WP_075575712.1	peptide cleavage/export ABC transporter	Regulator
DQL00_RS11290	-	2116460..2117821 (+)	1362	Protein_2098	bacteriocin secretion accessory protein	-
DQL00_RS11295	blpC	2117878..2118033 (+)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
DQL00_RS11300	-	2118075..2119415 (-)	1341	WP_001028044.1	sensor histidine kinase	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=1142995 DQL00_RS12405 WP_000205166.1 2114292..2114879(+) (comA/nlmT) [Streptococcus pneumoniae strain 4041STDY6836169]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=1142995 DQL00_RS12405 WP_000205166.1 2114292..2114879(+) (comA/nlmT) [Streptococcus pneumoniae strain 4041STDY6836169]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497