Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   DQL26_RS04970 Genome accession   NZ_LS483521
Coordinates   973318..973992 (-) Length   224 a.a.
NCBI ID   WP_002984519.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC8316     
Function   repress competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 934642..1007549 973318..973992 within 0


Gene organization within MGE regions


Location: 934642..1007549
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL26_RS04795 (NCTC8316_00957) xerS 934642..935712 (-) 1071 WP_002984598.1 tyrosine recombinase XerS -
  DQL26_RS04800 (NCTC8316_00958) - 936186..936884 (+) 699 WP_002993300.1 XRE family transcriptional regulator -
  DQL26_RS04805 (NCTC8316_00959) ffh 937001..938563 (-) 1563 WP_111693225.1 signal recognition particle protein -
  DQL26_RS04810 (NCTC8316_00960) - 938578..938910 (-) 333 WP_002989745.1 putative DNA-binding protein -
  DQL26_RS04815 (NCTC8316_00961) - 939008..939706 (-) 699 WP_002989743.1 GntR family transcriptional regulator -
  DQL26_RS04820 (NCTC8316_00962) - 939789..941222 (-) 1434 WP_111693226.1 hypothetical protein -
  DQL26_RS04825 (NCTC8316_00963) guaA 941389..942951 (+) 1563 WP_111693227.1 glutamine-hydrolyzing GMP synthase -
  DQL26_RS04830 (NCTC8316_00964) - 942993..944216 (-) 1224 WP_038434107.1 aminoacyltransferase -
  DQL26_RS04835 (NCTC8316_00965) - 944582..946126 (-) 1545 WP_011017795.1 ABC-F family ATP-binding cassette domain-containing protein -
  DQL26_RS04840 (NCTC8316_00966) - 946260..946817 (-) 558 WP_011017797.1 ECF transporter S component -
  DQL26_RS04845 (NCTC8316_00967) - 946795..947661 (-) 867 WP_038434109.1 pyridoxamine kinase -
  DQL26_RS04850 (NCTC8316_00968) - 947751..949019 (+) 1269 WP_038434110.1 PLP-dependent aminotransferase family protein -
  DQL26_RS04855 (NCTC8316_00969) - 949490..949828 (-) 339 WP_002989726.1 ATP cone domain-containing protein -
  DQL26_RS04860 (NCTC8316_00971) cls 950167..951744 (-) 1578 WP_038434111.1 cardiolipin synthase -
  DQL26_RS04865 (NCTC8316_00972) - 951829..953499 (-) 1671 WP_023610812.1 formate--tetrahydrofolate ligase -
  DQL26_RS04870 (NCTC8316_00973) - 953627..954646 (-) 1020 WP_111688282.1 lipoate--protein ligase -
  DQL26_RS04875 (NCTC8316_00974) - 954693..955574 (-) 882 WP_032465032.1 SIR2 family NAD-dependent protein deacylase -
  DQL26_RS04880 (NCTC8316_00975) - 955567..956379 (-) 813 WP_009880444.1 protein-ADP-ribose hydrolase -
  DQL26_RS04885 (NCTC8316_00976) - 956372..956704 (-) 333 WP_002984553.1 glycine cleavage system protein H -
  DQL26_RS04890 (NCTC8316_00977) - 956746..957744 (-) 999 WP_010922345.1 LLM class flavin-dependent oxidoreductase -
  DQL26_RS04895 (NCTC8316_00978) - 957741..958940 (-) 1200 WP_020833498.1 NADH-dependent flavin oxidoreductase -
  DQL26_RS04900 (NCTC8316_00979) - 958937..959773 (-) 837 WP_012560736.1 biotin/lipoate A/B protein ligase family protein -
  DQL26_RS04905 (NCTC8316_00980) coaB 959975..960661 (+) 687 WP_010922346.1 phosphopantothenate--cysteine ligase -
  DQL26_RS04910 (NCTC8316_00981) coaC 960654..961199 (+) 546 WP_038434114.1 phosphopantothenoylcysteine decarboxylase -
  DQL26_RS04915 (NCTC8316_00982) - 961257..961826 (+) 570 WP_002984543.1 ECF transporter S component -
  DQL26_RS04920 (NCTC8316_00983) - 962002..963720 (+) 1719 WP_038434115.1 phospho-sugar mutase -
  DQL26_RS04925 (NCTC8316_00984) - 963933..964889 (-) 957 WP_010922349.1 ABC transporter permease -
  DQL26_RS04930 (NCTC8316_00985) - 964891..965955 (-) 1065 WP_111693228.1 ABC transporter permease -
  DQL26_RS04935 (NCTC8316_00986) - 965948..967480 (-) 1533 WP_038434116.1 ABC transporter ATP-binding protein -
  DQL26_RS04940 (NCTC8316_00987) - 967619..968671 (-) 1053 WP_002989701.1 BMP family lipoprotein -
  DQL26_RS04945 (NCTC8316_00988) - 968765..969154 (-) 390 WP_011285547.1 cytidine deaminase -
  DQL26_RS04950 (NCTC8316_00989) - 969807..970400 (-) 594 WP_010922352.1 class I SAM-dependent methyltransferase -
  DQL26_RS04955 (NCTC8316_00990) coaA 970668..971588 (+) 921 WP_014407609.1 type I pantothenate kinase -
  DQL26_RS04960 (NCTC8316_00991) rpsT 971642..971890 (+) 249 WP_009881183.1 30S ribosomal protein S20 -
  DQL26_RS04965 (NCTC8316_00992) ciaH 972015..973325 (-) 1311 WP_085634321.1 sensor histidine kinase Regulator
  DQL26_RS04970 (NCTC8316_00993) ciaR 973318..973992 (-) 675 WP_002984519.1 response regulator transcription factor Regulator
  DQL26_RS04975 (NCTC8316_00994) - 974339..976876 (-) 2538 WP_014407610.1 M1 family metallopeptidase -
  DQL26_RS04985 (NCTC8316_00995) phoU 977081..977734 (-) 654 WP_002984514.1 phosphate signaling complex protein PhoU -
  DQL26_RS04990 (NCTC8316_00996) pstB 977802..978560 (-) 759 WP_002993892.1 phosphate ABC transporter ATP-binding protein PstB -
  DQL26_RS04995 (NCTC8316_00997) pstB 978573..979376 (-) 804 WP_002984509.1 phosphate ABC transporter ATP-binding protein PstB -
  DQL26_RS05000 (NCTC8316_00998) pstA 979392..980279 (-) 888 WP_002989688.1 phosphate ABC transporter permease PstA -
  DQL26_RS05005 (NCTC8316_00999) pstC 980269..981204 (-) 936 WP_010922359.1 phosphate ABC transporter permease subunit PstC -
  DQL26_RS05010 (NCTC8316_01000) - 981215..982081 (-) 867 WP_002989684.1 phosphate ABC transporter substrate-binding protein PstS family protein -
  DQL26_RS05015 (NCTC8316_01001) - 982220..983527 (-) 1308 WP_281726978.1 RsmF rRNA methyltransferase first C-terminal domain-containing protein -
  DQL26_RS05020 (NCTC8316_01002) - 983533..984321 (-) 789 WP_002984499.1 inositol monophosphatase family protein -
  DQL26_RS05025 (NCTC8316_01003) - 984311..984589 (-) 279 WP_002984497.1 UPF0223 family protein -
  DQL26_RS05030 (NCTC8316_01004) - 984591..984995 (-) 405 WP_002984496.1 Spx/MgsR family RNA polymerase-binding regulatory protein -
  DQL26_RS05035 (NCTC8316_01005) - 985038..985970 (-) 933 WP_111693230.1 bifunctional riboflavin kinase/FAD synthetase -
  DQL26_RS05040 (NCTC8316_01006) truB 985999..986883 (-) 885 WP_002989678.1 tRNA pseudouridine(55) synthase TruB -
  DQL26_RS05045 (NCTC8316_01007) - 986999..988339 (-) 1341 WP_010922363.1 DUF2130 domain-containing protein -
  DQL26_RS05050 (NCTC8316_01008) - 988436..989392 (-) 957 WP_111693231.1 aromatic acid exporter family protein -
  DQL26_RS05055 (NCTC8316_01009) - 989403..989999 (-) 597 WP_002993908.1 restriction endonuclease subunit S -
  DQL26_RS05060 (NCTC8316_01010) - 990091..992727 (-) 2637 WP_111693232.1 FtsX-like permease family protein -
  DQL26_RS05065 (NCTC8316_01011) - 992742..993443 (-) 702 WP_111693233.1 ABC transporter ATP-binding protein -
  DQL26_RS05070 (NCTC8316_01012) - 993561..994103 (+) 543 WP_002984482.1 TetR/AcrR family transcriptional regulator -
  DQL26_RS05075 (NCTC8316_01013) - 994246..994887 (-) 642 WP_002984480.1 GntR family transcriptional regulator -
  DQL26_RS05080 (NCTC8316_01014) - 995050..995538 (-) 489 WP_002994467.1 Asp23/Gls24 family envelope stress response protein -
  DQL26_RS05085 (NCTC8316_01015) - 995549..995749 (-) 201 WP_002984476.1 CsbD family protein -
  DQL26_RS05090 (NCTC8316_01016) - 995790..996329 (-) 540 WP_002984475.1 Asp23/Gls24 family envelope stress response protein -
  DQL26_RS05095 (NCTC8316_01017) - 996342..996530 (-) 189 WP_002984473.1 DUF2273 domain-containing protein -
  DQL26_RS05100 (NCTC8316_01018) amaP 996541..997128 (-) 588 WP_021775499.1 alkaline shock response membrane anchor protein AmaP -
  DQL26_RS05105 (NCTC8316_01019) - 997189..997437 (-) 249 WP_002984469.1 GlsB/YeaQ/YmgE family stress response membrane protein -
  DQL26_RS05110 (NCTC8316_01020) pcrA 997800..1000118 (-) 2319 WP_111693234.1 DNA helicase PcrA -
  DQL26_RS05115 (NCTC8316_01022) - 1000647..1001969 (+) 1323 WP_032460380.1 alanine/glycine:cation symporter family protein -
  DQL26_RS05120 (NCTC8316_01023) - 1002089..1003324 (+) 1236 WP_023078165.1 cation diffusion facilitator family transporter -
  DQL26_RS05125 (NCTC8316_01025) - 1003669..1004774 (+) 1106 WP_111693067.1 IS3 family transposase -
  DQL26_RS05130 (NCTC8316_01026) cfa 1004915..1005688 (-) 774 WP_009880829.1 CAMP factor pore-forming toxin Cfa -
  DQL26_RS05135 (NCTC8316_01027) - 1006068..1006904 (-) 837 WP_002989634.1 amino acid ABC transporter substrate-binding protein -
  DQL26_RS05140 (NCTC8316_01028) - 1006920..1007549 (-) 630 WP_014407625.1 amino acid ABC transporter ATP-binding protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25703.91 Da        Isoelectric Point: 4.7287

>NTDB_id=1142839 DQL26_RS04970 WP_002984519.1 973318..973992(-) (ciaR) [Streptococcus pyogenes strain NCTC8316]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGKVVELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKKLKGTRFVNRLQTLRSVGYILKNNE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1142839 DQL26_RS04970 WP_002984519.1 973318..973992(-) (ciaR) [Streptococcus pyogenes strain NCTC8316]
ATGATAAAAATATTATTAGTAGAAGATGACTTGAGCTTATCAAATTCCATTTTTGATTTTTTAGATGATTTTGCAGACGT
CATGCAAGTTTTTGATGGCGATGAAGGTTTATACGAAGCAGAAAGTGGTATTTATGATTTGATTTTGTTAGACCTTATGT
TGCCGGAGAAAAATGGCTTTCAAGTCTTAAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTGTTGATCATGACAGCT
AAAGAGGGTTTAGATGATAAAGGTCACGGATTTGAATTAGGTGCTGATGATTATCTGACCAAGCCGTTCTATTTAGAAGA
GTTAAAAATGCGAATTCAAGCACTGTTAAAAAGAACAGGGAAATTTGCAGATAAAAATATTAGTTTTGGCAATTTAGTGG
TTGACTTAGCTCGAAAAGAGGTGAAGGTTGAAGGGAAAGTAGTTGAATTACTTGGCAAAGAATTTGATTTGTTGGTGTAT
CTTTTGCAAAATCAAAACGTTATTTTACCAAAGACACAAATTTTTGATCGTTTATGGGGATTCGATAGTGATACTACGAT
TTCGGTTGTTGAAGTTTACATTTCTAAAATAAGAAAAAAATTAAAAGGTACCCGTTTTGTTAACAGGCTTCAAACTTTAA
GAAGCGTAGGGTATATTCTAAAAAACAATGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

85.135

99.107

0.844
  ciaR Streptococcus pneumoniae D39

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae R6

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae TIGR4

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae Rx1

84.685

99.107

0.839
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.111

100

0.393
  vicR Streptococcus mutans UA159

35.897

100

0.375
  micA Streptococcus pneumoniae Cp1015

35.47

100

0.371
  covR Streptococcus salivarius strain HSISS4

36.283

100

0.366

Multiple sequence alignment