Detailed information NTG1142030

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: DQL12_RS12525
• Genome accession: NZ_LS483450
• Coordinates: 497282..497869 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain 4041STDY6583227
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 492282..502869

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL12_RS02655	-	492744..494084 (+)	1341	WP_001017646.1	sensor histidine kinase	-
DQL12_RS02660	blpC	494155..494283 (-)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
DQL12_RS02665	-	494340..495701 (-)	1362	WP_001069075.1	bacteriocin secretion accessory protein	-
DQL12_RS02670	comA/nlmT	495712..497388 (-)	1677	WP_162480916.1	peptide cleavage/export ABC transporter	Regulator
DQL12_RS12525	comA/nlmT	497282..497869 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
DQL12_RS02675	blpI	498151..498348 (+)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
DQL12_RS02685	blpJ	498815..499084 (+)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
DQL12_RS02690	blpU	499153..499383 (+)	231	WP_000379967.1	bacteriocin-like peptide BlpU	-
DQL12_RS02695	-	499386..499505 (+)	120	WP_000346298.1	PncF family bacteriocin immunity protein	-
DQL12_RS02700	-	499802..499966 (+)	165	WP_000727118.1	hypothetical protein	-
DQL12_RS02705	-	499963..500367 (+)	405	WP_000846943.1	hypothetical protein	-
DQL12_RS02710	-	500570..501374 (+)	805	WP_111695758.1	IS5 family transposase	-
DQL12_RS02715	blpM	501524..501778 (+)	255	WP_000379879.1	two-peptide bacteriocin subunit BlpM	-
DQL12_RS02720	blpN	501794..501997 (+)	204	WP_050255686.1	two-peptide bacteriocin subunit BlpN	-
DQL12_RS02730	cipB	502241..502390 (+)	150	WP_001818346.1	bacteriocin-like peptide BlpO	Regulator
DQL12_RS02735	-	502494..502613 (+)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=1142030 DQL12_RS12525 WP_000205166.1 497282..497869(-) (comA/nlmT) [Streptococcus pneumoniae strain 4041STDY6583227]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=1142030 DQL12_RS12525 WP_000205166.1 497282..497869(-) (comA/nlmT) [Streptococcus pneumoniae strain 4041STDY6583227]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497