Detailed information    

insolico Bioinformatically predicted

Overview

Name   dprA/cilB/dalA   Type   Machinery gene
Locus tag   DQL12_RS06645 Genome accession   NZ_LS483450
Coordinates   1253994..1254842 (-) Length   282 a.a.
NCBI ID   WP_000705306.1    Uniprot ID   A0A098Z7D2
Organism   Streptococcus pneumoniae strain 4041STDY6583227     
Function   ssDNA binding; loading RecA onto ssDNA; competence shut-off (predicted from homology)   
DNA processing Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
IS/Tn 1252231..1253184 1253994..1254842 flank 810


Gene organization within MGE regions


Location: 1252231..1254842
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL12_RS06640 - 1252231..1253184 (-) 954 WP_050255693.1 IS30-like element ISSpn8 family transposase -
  DQL12_RS12485 - 1253688..1253810 (+) 123 WP_001814242.1 hypothetical protein -
  DQL12_RS06645 dprA/cilB/dalA 1253994..1254842 (-) 849 WP_000705306.1 DNA-processing protein DprA Machinery gene

Sequence

Protein


Download         Length: 282 a.a.        Molecular weight: 31062.72 Da        Isoelectric Point: 5.4047

>NTDB_id=1141981 DQL12_RS06645 WP_000705306.1 1253994..1254842(-) (dprA/cilB/dalA) [Streptococcus pneumoniae strain 4041STDY6583227]
MKITNYEIYKLKKSGLTNQQILKVLEYGENVDQELLLGDIADISGCRNPAVFMERYFQIDDAHLSKEFQKFPSFSILDDC
YPWDLSEIYDAPVLLFYKGNLDLLKFPKVAVVGSRACSKQGAKSVEKVIQGLENELVIVSGLAKGIDTAAHMAALQNGGK
TIAVIGTGLDVFYPKANKRLQDYIGNDHLVLSEYGPGEQPLKFHFPARNRIIAGLCRGVIVAEAKMRSGSLITCERAMEE
GRDVFAIPGSILDGLSDGCHHLIQEGAKLVTSGQDVLAEFEF

Nucleotide


Download         Length: 849 bp        

>NTDB_id=1141981 DQL12_RS06645 WP_000705306.1 1253994..1254842(-) (dprA/cilB/dalA) [Streptococcus pneumoniae strain 4041STDY6583227]
ATGAAAATCACAAACTATGAAATCTATAAGTTAAAAAAATCAGGTTTGACCAATCAACAGATTTTGAAAGTTCTAGAATA
CGGTGAAAATGTTGATCAGGAGCTTTTGTTGGGTGATATTGCAGATATATCAGGTTGCCGTAATCCAGCCGTTTTTATGG
AACGTTATTTTCAGATAGACGATGCGCATTTGTCGAAAGAGTTTCAAAAATTTCCATCTTTCTCTATTTTAGATGACTGT
TATCCTTGGGATTTGAGTGAAATATATGATGCGCCTGTACTTTTATTTTACAAGGGAAATCTTGACCTCCTGAAATTCCC
GAAGGTAGCGGTCGTGGGCAGTCGTGCTTGTAGCAAACAGGGAGCTAAATCAGTTGAAAAAGTCATTCAAGGCTTGGAAA
ATGAACTGGTTATTGTCAGTGGTCTGGCCAAGGGCATTGACACAGCAGCTCATATGGCAGCTCTTCAGAATGGCGGAAAA
ACCATTGCAGTGATTGGAACAGGACTGGATGTGTTTTATCCTAAAGCCAATAAACGCTTGCAAGACTACATCGGCAATGA
CCATCTGGTTCTAAGTGAATATGGACCTGGCGAACAACCTCTGAAATTTCATTTTCCTGCCCGTAATCGCATCATTGCTG
GACTTTGTCGTGGTGTGATTGTAGCAGAGGCTAAGATGCGTTCAGGTAGTCTCATTACGTGTGAGCGAGCAATGGAAGAA
GGACGCGATGTCTTTGCTATTCCTGGTAGCATTTTAGATGGACTATCAGACGGTTGCCATCATTTGATTCAAGAAGGAGC
AAAATTGGTCACCAGTGGGCAAGATGTTCTTGCGGAATTTGAATTTTAA

Domains

Predicted by InterproScan.

DNA recombination-mediator protein A (DNA_processg_A)

(75-271)

DNA processing protein A sterile alpha motif domain (SAM_DprA)

(3-64)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A098Z7D2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  dprA/cilB/dalA Streptococcus pneumoniae Rx1

100

100

1
  dprA/cilB/dalA Streptococcus pneumoniae D39

100

100

1
  dprA/cilB/dalA Streptococcus pneumoniae R6

100

100

1
  dprA/cilB/dalA Streptococcus pneumoniae TIGR4

100

100

1
  dprA/cilB/dalA Streptococcus mitis NCTC 12261

98.582

100

0.986
  dprA/cilB/dalA Streptococcus mitis SK321

97.872

100

0.979
  dprA Streptococcus mutans UA159

63.214

99.291

0.628
  dprA Lactococcus lactis subsp. cremoris KW2

55.714

99.291

0.553
  dprA Staphylococcus aureus N315

37.809

100

0.379
  dprA Haemophilus influenzae Rd KW20

38.202

94.681

0.362

Multiple sequence alignment