Detailed information NTG1141952

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: DQK98_RS12195
• Genome accession: NZ_LS483449
• Coordinates: 505063..505650 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain 4041STDY6836170
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 500063..510650

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQK98_RS02635	-	500525..501865 (+)	1341	WP_001099895.1	sensor histidine kinase	-
DQK98_RS02640	blpC	501909..502064 (-)	156	WP_044791640.1	quorum-sensing system pheromone BlpC	-
DQK98_RS02645	-	502121..503482 (-)	1362	Protein_504	bacteriocin secretion accessory protein	-
DQK98_RS02650	comA/nlmT	503493..505169 (-)	1677	WP_196299874.1	peptide cleavage/export ABC transporter	Regulator
DQK98_RS12195	comA/nlmT	505063..505650 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
DQK98_RS02655	blpM	505932..506186 (+)	255	WP_001093256.1	two-peptide bacteriocin subunit BlpM	-
DQK98_RS02660	blpN	506202..506405 (+)	204	WP_001099490.1	two-peptide bacteriocin subunit BlpN	-
DQK98_RS02670	cipB	506649..506798 (+)	150	WP_001809846.1	bacteriocin-like peptide BlpO	Regulator
DQK98_RS02675	-	506902..507021 (+)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
DQK98_RS02680	-	507319..507483 (+)	165	WP_000727117.1	hypothetical protein	-
DQK98_RS02685	-	507545..507883 (+)	339	WP_088804618.1	immunity protein	-
DQK98_RS02695	-	508512..508895 (+)	384	WP_000877381.1	hypothetical protein	-
DQK98_RS02700	-	508947..509636 (+)	690	WP_000760520.1	CPBP family intramembrane glutamic endopeptidase	-
DQK98_RS02705	blpZ	509678..509926 (+)	249	WP_000276501.1	immunity protein BlpZ	-
DQK98_RS02710	-	509956..510567 (+)	612	WP_000394036.1	CPBP family intramembrane glutamic endopeptidase	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=1141952 DQK98_RS12195 WP_000205166.1 505063..505650(-) (comA/nlmT) [Streptococcus pneumoniae strain 4041STDY6836170]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=1141952 DQK98_RS12195 WP_000205166.1 505063..505650(-) (comA/nlmT) [Streptococcus pneumoniae strain 4041STDY6836170]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATCGGTGGTT
CTTATTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497