Detailed information NTG1141876

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: DQK99_RS12630
• Genome accession: NZ_LS483448
• Coordinates: 531931..532518 (-)
• Length: 195 a.a.
• NCBI ID: WP_001810228.1
• Uniprot ID: A0A380LSF4
• Organism: Streptococcus pneumoniae strain 4041STDY6836167
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 526931..537518

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQK99_RS02860	-	527395..528735 (+)	1341	WP_001017638.1	sensor histidine kinase	-
DQK99_RS02865	blpC	528777..528932 (-)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
DQK99_RS02870	-	528989..530350 (-)	1362	WP_001069091.1	bacteriocin secretion accessory protein	-
DQK99_RS02875	comA/nlmT	530361..532037 (-)	1677	WP_196299874.1	peptide cleavage/export ABC transporter	Regulator
DQK99_RS12630	comA/nlmT	531931..532518 (-)	588	WP_001810228.1	cysteine peptidase family C39 domain-containing protein	Regulator
DQK99_RS02880	blpI	532800..532997 (+)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
DQK99_RS02890	blpJ	533464..533733 (+)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
DQK99_RS02895	blpU	533802..534032 (+)	231	WP_000379964.1	bacteriocin-like peptide BlpU	-
DQK99_RS02900	-	534035..534154 (+)	120	WP_000346298.1	PncF family bacteriocin immunity protein	-
DQK99_RS02905	-	534451..534615 (+)	165	WP_000727118.1	hypothetical protein	-
DQK99_RS02910	-	534612..535016 (+)	405	WP_000846944.1	hypothetical protein	-
DQK99_RS02915	-	535214..536019 (+)	806	Protein_558	IS5 family transposase	-
DQK99_RS02920	blpM	536169..536423 (+)	255	WP_000379879.1	two-peptide bacteriocin subunit BlpM	-
DQK99_RS02925	blpN	536439..536642 (+)	204	WP_001099492.1	two-peptide bacteriocin subunit BlpN	-
DQK99_RS02935	cipB	536886..537035 (+)	150	WP_001809846.1	bacteriocin-like peptide BlpO	Regulator
DQK99_RS02940	-	537139..537258 (+)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22369.84 Da
• Isoelectric Point: 9.7306

>NTDB_id=1141876 DQK99_RS12630 WP_001810228.1 531931..532518(-) (comA/nlmT) [Streptococcus pneumoniae strain 4041STDY6836167]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLR

Nucleotide

• Length: 588 bp

>NTDB_id=1141876 DQK99_RS12630 WP_001810228.1 531931..532518(-) (comA/nlmT) [Streptococcus pneumoniae strain 4041STDY6836167]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTAGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: A0A380LSF4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497