Detailed information NTG1141826

Bioinformatically predicted

Overview

• Name: dprA/cilB/dalA
• Type: Machinery gene
• Locus tag: DQK99_RS06305
• Genome accession: NZ_LS483448
• Coordinates: 1189490..1190338 (-)
• Length: 282 a.a.
• NCBI ID: WP_000705306.1
• Uniprot ID: A0A098Z7D2
• Organism: Streptococcus pneumoniae strain 4041STDY6836167
• Function: ssDNA binding; loading RecA onto ssDNA; competence shut-off (predicted from homology) DNA processing Competence regulation

Genomic Context

Location: 1184490..1195338

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQK99_RS06290	-	1184842..1185201 (-)	360	WP_001237219.1	YbaN family protein	-
DQK99_RS06295	topA	1185307..1187394 (-)	2088	WP_000179650.1	type I DNA topoisomerase	-
DQK99_RS06300	-	1187562..1188605 (-)	1044	WP_001812957.1	TIGR00341 family protein	-
DQK99_RS12550	-	1189184..1189306 (+)	123	WP_001818236.1	hypothetical protein	-
DQK99_RS06305	dprA/cilB/dalA	1189490..1190338 (-)	849	WP_000705306.1	DNA-processing protein DprA	Machinery gene
DQK99_RS06310	-	1190434..1191123 (-)	690	WP_000643963.1	sugar phosphate nucleotidyltransferase	-
DQK99_RS06315	-	1191135..1192013 (-)	879	WP_000837618.1	DMT family transporter	-
DQK99_RS06320	licA	1192003..1192872 (-)	870	WP_000411209.1	choline kinase LicA	-
DQK99_RS06325	-	1192889..1193911 (-)	1023	WP_000609893.1	ribitol-5-phosphate dehydrogenase	-
DQK99_RS06330	-	1193916..1194623 (-)	708	WP_000638500.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-

Sequence

Protein

• Length: 282 a.a.
• Molecular weight: 31062.72 Da
• Isoelectric Point: 5.4047

>NTDB_id=1141826 DQK99_RS06305 WP_000705306.1 1189490..1190338(-) (dprA/cilB/dalA) [Streptococcus pneumoniae strain 4041STDY6836167]
MKITNYEIYKLKKSGLTNQQILKVLEYGENVDQELLLGDIADISGCRNPAVFMERYFQIDDAHLSKEFQKFPSFSILDDC
YPWDLSEIYDAPVLLFYKGNLDLLKFPKVAVVGSRACSKQGAKSVEKVIQGLENELVIVSGLAKGIDTAAHMAALQNGGK
TIAVIGTGLDVFYPKANKRLQDYIGNDHLVLSEYGPGEQPLKFHFPARNRIIAGLCRGVIVAEAKMRSGSLITCERAMEE
GRDVFAIPGSILDGLSDGCHHLIQEGAKLVTSGQDVLAEFEF

Nucleotide

• Length: 849 bp

>NTDB_id=1141826 DQK99_RS06305 WP_000705306.1 1189490..1190338(-) (dprA/cilB/dalA) [Streptococcus pneumoniae strain 4041STDY6836167]
ATGAAAATCACAAACTATGAAATCTATAAGTTAAAAAAATCAGGTTTGACCAATCAACAGATTTTGAAAGTGCTAGAATA
CGGTGAAAATGTTGATCAGGAGCTTTTGTTGGGTGATATTGCAGATATATCAGGTTGCCGTAATCCAGCCGTTTTTATGG
AACGTTATTTTCAGATAGACGATGCGCATTTGTCGAAAGAGTTTCAAAAATTTCCATCTTTCTCTATTTTAGATGACTGT
TATCCTTGGGATTTGAGTGAAATATATGATGCGCCTGTACTTTTATTTTACAAGGGAAATCTTGACCTCCTGAAATTCCC
GAAGGTAGCGGTCGTGGGCAGTCGTGCTTGTAGCAAACAGGGAGCTAAGTCAGTTGAAAAAGTCATTCAAGGCTTGGAAA
ATGAACTGGTTATTGTCAGTGGTCTGGCCAAGGGCATTGACACAGCAGCTCATATGGCAGCTCTTCAGAATGGCGGAAAA
ACCATTGCAGTGATTGGAACAGGACTGGATGTGTTTTATCCTAAAGCCAATAAACGCTTGCAAGACTACATCGGCAATGA
CCATCTGGTTCTAAGTGAATATGGACCTGGCGAACAACCTCTGAAATTTCATTTTCCTGCCCGTAATCGCATCATTGCTG
GACTTTGTCGTGGTGTGATTGTAGCAGAGGCTAAGATGCGTTCAGGTAGTCTCATTACGTGTGAGCGAGCAATGGAAGAA
GGACGCGATGTCTTTGCTATTCCTGGTAGCATTTTAGATGGACTATCAGACGGTTGCCATCATTTGATTCAAGAAGGAGC
AAAATTGGTCACCAGTGGGCAAGATGTTCTTGCGGAATTTGAATTTTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (75-271)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (3-64)

3D structure

• AlphaFold DB: A0A098Z7D2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	100	100	1
dprA/cilB/dalA	Streptococcus pneumoniae D39	100	100	1
dprA/cilB/dalA	Streptococcus pneumoniae R6	100	100	1
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	100	100	1
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	98.582	100	0.986
dprA/cilB/dalA	Streptococcus mitis SK321	97.872	100	0.979
dprA	Streptococcus mutans UA159	63.214	99.291	0.628
dprA	Lactococcus lactis subsp. cremoris KW2	55.714	99.291	0.553
dprA	Staphylococcus aureus N315	37.809	100	0.379
dprA	Haemophilus influenzae Rd KW20	38.202	94.681	0.362