Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   DQL20_RS04185 Genome accession   NZ_LS483444
Coordinates   777205..777879 (+) Length   224 a.a.
NCBI ID   WP_006596563.1    Uniprot ID   -
Organism   Streptococcus australis strain NCTC13166     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 772205..782879
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL20_RS04165 (NCTC11371_00821) phoU 772362..773015 (+) 654 WP_006596567.1 phosphate signaling complex protein PhoU -
  DQL20_RS04170 (NCTC11371_00822) - 773146..775689 (+) 2544 WP_006597322.1 M1 family metallopeptidase -
  DQL20_RS04175 (NCTC11371_00823) - 775744..776286 (-) 543 WP_006597327.1 biotin transporter BioY -
  DQL20_RS04180 (NCTC11371_00824) - 776495..777091 (+) 597 WP_006596564.1 hypothetical protein -
  DQL20_RS04185 (NCTC11371_00825) ciaR 777205..777879 (+) 675 WP_006596563.1 response regulator transcription factor Regulator
  DQL20_RS04190 (NCTC11371_00826) ciaH 777869..779242 (+) 1374 WP_006596562.1 cell wall metabolism sensor histidine kinase WalK Regulator
  DQL20_RS04200 (NCTC11371_00827) - 779493..779879 (+) 387 WP_006596561.1 VOC family protein -
  DQL20_RS04205 (NCTC11371_00828) - 780075..781460 (+) 1386 WP_006596560.1 polysaccharide deacetylase family protein -
  DQL20_RS04210 (NCTC11371_00829) - 781769..782857 (-) 1089 WP_006596559.1 DEAD/DEAH box helicase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25324.05 Da        Isoelectric Point: 4.3320

>NTDB_id=1141745 DQL20_RS04185 WP_006596563.1 777205..777879(+) (ciaR) [Streptococcus australis strain NCTC13166]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKDGFQVLKELRDKGVSTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKVNENTLSYGNVTVNLSTNSTLVEGKEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTDFAKNLQTLRSVGYILKDAQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1141745 DQL20_RS04185 WP_006596563.1 777205..777879(+) (ciaR) [Streptococcus australis strain NCTC13166]
ATGATTAAGATTTTATTAGTCGAAGACGACCTCGGTTTGTCTAATTCAGTATTTGATTTTTTAGATGATTTTGCGGATGT
CATGCAAGTCTTTGATGGGGATGAAGGTCTGTATGAGGCTGAAAGTGGCATCTATGACCTCATTTTGCTAGATCTCATGC
TTCCTGAAAAAGATGGTTTCCAAGTTCTGAAAGAATTGAGAGATAAGGGTGTCTCCACTCCAGTATTGATTATGACAGCC
AAAGAGAGTTTGGACGATAAGGGCCATGGGTTTGAGCTAGGGGCAGATGACTATCTGACCAAGCCATTCTACCTAGAAGA
ACTCAAGATGCGGATCCAAGCATTGTTGAAGCGCTCTGGTAAGGTCAATGAAAATACCCTTTCGTATGGGAATGTGACCG
TTAATCTCTCGACTAACTCTACGCTTGTTGAAGGAAAAGAAGTAGAACTATTAGGAAAAGAATTTGATCTCTTGGTCTAT
TTCCTTCAAAATCAAAATGTTATCCTGCCAAAAACACAAATCTTTGATCGACTTTGGGGATTTGATAGTGATACGACTAT
CTCGGTTGTCGAAGTGTATGTTTCTAAGATTCGTAAGAAGTTAAAAGGAACAGACTTTGCAAAAAATCTCCAAACATTGC
GTAGCGTGGGGTACATTCTGAAAGATGCTCAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

90.625

100

0.906
  ciaR Streptococcus pneumoniae D39

90.625

100

0.906
  ciaR Streptococcus pneumoniae R6

90.625

100

0.906
  ciaR Streptococcus pneumoniae TIGR4

90.625

100

0.906
  ciaR Streptococcus mutans UA159

87.946

100

0.879
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.428

100

0.393
  vicR Streptococcus mutans UA159

35.622

100

0.371
  covR Streptococcus salivarius strain HSISS4

35.841

100

0.362

Multiple sequence alignment